2015 American Transplant Congress
Defining and Directing T Cell Subsets Involved in Rejection of Vascularized Composite Allografts
Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD.
Purpose: Wider utilization of VCA is hampered by the need for long-term immunosuppression. Barriers to more targeted immunosuppression in VCA include (1) limited knowledge of…2015 American Transplant Congress
A Mouse Model of Pneumonitis Induced by Candida Albicans Infection After Allogeneic Skin Transplantation
Aims:Our study was to build up a mouse model of pneumonitis induced by candida albicans infection after allogeneic skin transplantation.Methods:We used 10 male C57BL/6J mice…2015 American Transplant Congress
IL-2/IL-2 Ab Complex Leads to Long-Term Tolerance in a Treg Dependent DST Model of Skin Allograft Transplantation in Which DST and Timing of the Antibody Complex Are Crucial
1Children's Hospital at Westmead, Sydney, Australia; 2Garvan Institute, Sydney, Australia.
Background: In vivo Treg expansion using IL2 complexed with anti-IL2 antibody has been demonstrated to be effective in the induction of long-term acceptance of islet…2015 American Transplant Congress
Neonatal Tolerance: Donor and Host Cells Fuse in Livers of Newborn Mice Injected With F1-Bone Marrow/Spleen Cells
University of Alberta, Edmonton, Canada.
Purpose: Multiple liver cell-types induce immunological tolerance. Indeed liver allografts are often spontaneously accepted in humans and mice. The role of host liver in the…2015 American Transplant Congress
Presence of Donor Leukocytes and Donor MHC-Cross-Dressed Recipient Cells and Its Relationship to Direct T Cell Alloresponses After Allotransplantation
We have studied the kinetics of donor cell trafficking from the graft to recipient's lymphoid organs and its correlation to the direct T cell alloresponse…2015 American Transplant Congress
Activated Protein C Treatment Protects Steatotic and Non-Steatotic Livers Under Ischemia–Reperfusion Injury in Different Manner
Activated protein C (APC) is known to have the cytoprotective effect on liver ischemia–reperfusion injury (IRI) in rat models. However, it is unclear that whether…2015 American Transplant Congress
Tolerance to Graft A-Antigens Following ABO-Incompatible Heart Transplantation (HTx) in a Blood Group A-Transgenic Mouse Model
Purpose: ABOi HTx can be performed safely in infants when ABO antibody (Ab) levels are low or absent. Following ABOi HTx, immune tolerance develops to…2015 American Transplant Congress
ECDI Fixed Donor Splenocytes Combined With α-1 Antitrypsin Induce Immune Tolerance in Mice Cardiac Transplantation Model
Our previous study have shown that infusions of donor splenocytes fixed with 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide (ECDI-SPs) could prolong allografts survival in mice cardiac transplantation model. However, proinflammatory…2015 American Transplant Congress
Blocking CD40/CD154 Co-Stimulation Prevents Acute Antibody-Mediated Renal Allograft Rejection Induced by Memory CD4 T Cells
Immunology, The Cleveland Clinic, Cleveland, OH.
Immunosuppression-resistant alloreactive memory CD4 T cells induce robust responses against organ transplants. In murine heart allograft recipients donor-reactive memory CD4 T cells provide help for…2015 American Transplant Congress
ALDH Expression in Facilitating Cells Plays a Critical Role in Regulatory T Cell Induction and GVHD Prevention
Graft-vs-host disease (GVHD) is a major source of morbidity in hematopoietic stem cell transplantation (HSCT), limiting its application to treat nonmalignant hematopoietic diseases and to…
American Transplant Congress abstracts