2015 American Transplant Congress
B Cell Depletion With an Anti-CD20 Antibody Enhances Alloreactive Memory T Cell Response After Transplantation
Pre-transplant B cell depletion in NHP with Rituximab (IgG1 anti-CD20 mAb) combined with cyclosporin A has been shown to promote the survival of islets allografts.…2015 American Transplant Congress
Cell Type of the Tolerizing Inoculum Plays a Role in the Formation of of Molecular Chimerism in Murine Neonatal Tolerance
Background: Heart transplantation is a lifesaving measure for many infants with severe congenital heart diseases. The acceptance of cardiac allografts without immunosuppression, or operational tolerance,…2015 American Transplant Congress
Combined Anti-IL6R and CTLA4Ig Therapy Attenuates Recall Alloantibody Responses in a Mouse Model of HLA Sensitization
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
[bald]Background[/bald] We previously reported that IL-6 inhibition by anti-IL6R antibody (mMR16-1) or CD28 pathway inhibition using CTLA4Ig (abatacept) reduced recall alloantibody responses in a mouse…2015 American Transplant Congress
Eomes-Expressing CD8+ T Cells and Th17 Cells Mediate Costimulatory Blockade-Resistant Allograft Rejection in Mice
The etiology of costimulatory blockade-resistant allograft rejection remains unclear. Therefore, the purpose of this study was to evaluate the responsiveness of distinct CD4+ and CD8+…2015 American Transplant Congress
CD8+TCR– Bone Marrow Facilitating Cells Prime Migration and Enhance Homing of Hematopoietic Stem and Progenitor Cells
We recently reported the induction of chimerism and tolerance to renal allografts without GVHD or engraftment syndrome in HLA-mismatched living donor renal transplant recipients through…2015 American Transplant Congress
Donor Dendritic Cells – Potential New Therapeutic Target in Transplantation
Background: It is clear that T cells play a central role in the process of allograft rejection. However, donor dendritic cells (dDC) are the most…2015 American Transplant Congress
Donor MHC Independent Rejection of Islet Allografts in Autoimmune NOD Mice
In autoimmune Type 1 diabetes (T1D), pancreatic islet allografts have somewhat limited long-term survival, both in T1D human subjects and in spontaneously diseased non-obese diabetic…2015 American Transplant Congress
Effectiveness of Neovascularization Surrounding Engrafted Islets by Matrigel With Additional Growth Factors in Intramuscular Islet Transplantation
Introduction: Intramuscular islet transplantation is one of the promising transplant sites because of safety, easy accessibility and less invasive procedure. However the efficacy of the…2015 American Transplant Congress
Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allografts by Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2)
Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA) and Programmed death (PD)-1 had been suggested to have immunomodulatory activity. This study investigated the…2015 American Transplant Congress
miRNA-181 Promotes Graft Prolongation by Plasmacytoid Dendritic Cells By Increasing T Regulatory Cells and Decreasing B Cells as Revealed By Cytometry By Time-Of-Flight
1Surgery, Stanford University, Stanford, CA; 2Pediatrics, UCSF, San Francisco, CA.
Liver allografts are well tolerated and other solid organ allografts, when transplanted concurrently with livers, show improved outcomes. However, the mechanisms underlying “hepatic tolerance” have…
American Transplant Congress abstracts