Articles tagged "Mice"

2015 American Transplant Congress
Mesenchymal Stem Cells Prevent Cold Ischemia-Reperfusion Injury in Lung Transplants
H. Wang,^1,2 W. Tian,¹ Y. Liu,³ X. Dai,¹ G. Li,³ T. Liu,^1,2 Z. Zhang,^1,2 C. Du.⁴
¹Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China; ²Tianjin General Surgery Institute, Tianjin, China; ³Department of Biology, Tianjin Medical University, Tianjin, China; ⁴Department of Urologic Sciences, The University of British Columbia, Vancouver, BC, Canada.
Background: Cold ischemia-reperfusion injury (IRI) is a major cause of graft failure in lung transplantation. Despite therapeutic benefits of mesenchymal stem cells (MSCs) in attenuating…
2015 American Transplant Congress
Myeloid Cell-Specific Heme Oxygenase-1 Is Crucial for Hepatoprotection in Liver Ischemia-Reperfusion Injury
K. Nakamura,¹ M. Zhang,² B. Ke,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.
Background and Aim: Heme oxygenase-1 (HO-1), an anti-oxidant enzyme, is essential in tissue resistance against innate immunity driven ischemia-reperfusion injury (IRI). Our group was the…
2015 American Transplant Congress
Effects of Toll Like Receptor (TLR) Signaling on Murine Alloimmunity Are Modulated by Immune Cell Derived Complement
J. Sheen, P. Heeger.
Translational Transplant Research Center, Department of Medicine and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
TLR signals prevent CD40L-blockade (MR1) induced murine transplant tolerance but mechanisms are incompletely understood. Based on previous findings that immune cell derived complement activation products…
2015 American Transplant Congress
Phenotype Characterization, Migratory Pathways, Engraftment and Safety Evaluation of Human Cord Blood Derived Ex-Vivo Created Di- Chimeric Cells in NOD SCID Mouse Model: A Preliminary Study
J. Cwykiel,¹ A. Sklodowska,¹ W. Malewski,¹ M. Cyran,¹ H. Karagoz,¹ E. Bryndza Tfaily,¹ M. Askar,² M. Siemionow.¹
¹Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL; ²Transplant Center, Cleveland Clinic, Cleveland, OH.
PURPOSE: The aim of this study was to evaluate safety, survival, migration and engraftment of ex-vivo fused human cord blood derived di-chimeric cells (DCC) in…
2015 American Transplant Congress
Identification of Mouse Tolerogenic B Cells Expressing PD-L1/PD-L2 in B-1a Subset
T. Hirose,^1,2 Y. Tanaka,¹ H. Sakai,¹ Y. Sasaki,¹ H. Ohdan.¹
¹Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan; ²Renal and Genitourinary Surgery, Hokkaido University, Sapporo, Hokkaido, Japan.
Donor lymphocyte infusion (DLI) has been shown to induce donor-specific hyporesponsiveness or even immune-tolerance among alloreactive T cells in different organ transplantation models. However, the…
2015 American Transplant Congress
Upregulation of Heart Transplant IL-33 Is Critical in Cardiac Tissue Repair
Q. Liu, L. Mathews, J. Lott, B. Matta, H. Turnquist.
Starzl Transplantation Institute, Department of Surgery, Univ of Pittsburgh, Pittsburgh, PA.
Background: IL-33 is tissue-derived cytokine whose primary proposed function is to modulate immune responses when released during injury. Delivery of recombinant IL-33 protects cardiac allografts…
2015 American Transplant Congress
Mesenchymal Stromal Cells (MSCs) Given Post-Transplant Together With C3a and C5a Receptor Antagonists Prevent Engraftment Syndrome and Induce a Mild Not-Significant Prolongation of Graft Survival
F. Casiraghi,¹ M. Todeschini,¹ N. Azzollini,¹ P. Cravedi,² P. Heeger,² P. Cassis,¹ S. Solini,¹ N. Perico,¹ M. Noris,¹ G. Remuzzi.¹
¹IRCSS Mario Negri Institute, Bergamo, Italy; ²Icahn School of Medicine at Mount Sinai, New York, NY.
Bone marrow (BM)-derived MSC given the day before kidney allografts localize into lymphoid organs and induce significant prolongation of graft survival in mice. By contrast,…
2015 American Transplant Congress
Lymphatic Endothelium Uniquely Enhances T Cell Migration to S1P
C. Brinkman, Y. Xiong, J. Bromberg.
University of Maryland, Baltimore, MD.
Introduction: Sphingosine-1-phosphate (S1P) is a signaling sphingolipid that regulates cell egress from lymphoid and non-lymphoid tissues. While S1P has been described as a chemoattractant, its…
2015 American Transplant Congress
Immunological Aspects of Iron Overload in Heart and Kidney Transplantation
T. Resch,¹ S. Ebner,¹ P. Ritschl,¹ M. Ashraf,¹ C. Fabritius,¹ A. Brunner,² V. Nguyen,¹ J. Günther,¹ J. Pratschke,³ K. Kotsch.¹
¹Department of Surgery, Medical University Innsbruck, Innsbruck, Austria; ²Department of Pathology, Medical University Innsbruck, Innsbruck, Austria; ³Department of Surgery, Charité, Berlin, Germany.
Background: Clinical data suggest that iron (Fe) overload deleteriously affects graft survival after heart (HTX) and kidney transplantation (KTX) but possible immunologic mechanisms underlying this…
2015 American Transplant Congress
Liver Versus Kidney. A Functional Study on Pancreatic Islet Implantation Sites
T. Corsello,¹ G. Curcuru,² D. Zorzi,³ M. Montalbano,¹ B. Carr,¹ L. Cicalese,¹ C. Rastellini.¹
¹Surgery, UTMB, Galveston, TX; ²Bioingegneria, Univ. of Palermo, Palermo, Sicilia, Italy; ³Surgical Oncology, MD Anderson, Houston, TX.
Background: In the clinical setting, liver is the site currently used for pancreatic islet transplantation (ITX). However, it has been shown that over 50% of…