Articles tagged "Mice"

2015 American Transplant Congress
miRNA-181 Promotes Graft Prolongation by Plasmacytoid Dendritic Cells By Increasing T Regulatory Cells and Decreasing B Cells as Revealed By Cytometry By Time-Of-Flight
A. Lau,^1,2 M. Vitalone,¹ X. Qu,¹ T. Shawler,¹ O. Martinez,¹ C. Esquivel,¹ S. Krams.¹
¹Surgery, Stanford University, Stanford, CA; ²Pediatrics, UCSF, San Francisco, CA.
Liver allografts are well tolerated and other solid organ allografts, when transplanted concurrently with livers, show improved outcomes. However, the mechanisms underlying “hepatic tolerance” have…
2015 American Transplant Congress
Living and Dead Mesenchymal Stem Cells Induce an Immunosuppressive Response in an Experimental Sepsis Model
F. Luk,¹ M. Roemeling-van Rhijn,¹ S. de Witte,¹ S. Korevaar,¹ R. de Bruin,² M. Betjes,¹ C. Baan,¹ M. Hoogduijn.¹
¹Nephrology and Transplantation, Dept. of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands; ²Transplant Surgery, Dept. of Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
There is evolving interest in the use of mesenchymal stem cells (MSC) as a cell therapeutic agent after solid organ transplantation. The nature of the…
2015 American Transplant Congress
Transient Lymphopenia Breaks Costimulatory Blockade-Based Transplant Tolerance and Initiates Allograft Rejection
S. Iida,¹ T. Suzuki,² K. Tanabe,¹ A. Valujskikh,³ R. Fairchild,³ R. Abe.²
¹Urology, Tokyo Women's Medical Univ, Tokyo, Japan; ²Immunology, Science University of Tokyo, Chiba, Japan; ³Immunology, Cleveland Clinic, Cleveland, OH.
【Background and Objective】: Lymphopenia is induced by lymphoablative therapies and chronic viral infections. Lymphopenia is observed in some pathological and physiological processes, including chronic viral…
2015 American Transplant Congress
MDSC Derived from iPS Cells Regulate the CD8 T Cell Response In Vivo
D. Joyce,¹ M. Morita,² X.-K. Li,³ J. Fung,¹ S. Qian,^1,2 L. Lu.^1,2
¹General Surgery, Digestive Disease Institute; 2Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; ³Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Myeloid derived suppressor cells (MDSC) may represent a therapeutic tool for inducing tolerance in transplantation and autoimmune disorders. MDSC propagated from bone marrow (BM) can…
2015 American Transplant Congress
Proteasome Inhibition by Bortezomib Prevents Early Graft Failure After Pancreatic Islet Transplantation
H. Ono,¹ Y. Asahi,¹ T. Yoshida,¹ Y. Koshizuka,¹ M. Watanabe,¹ U. Tomaru,² S. Emoto,¹ M. Fukai,³ A. Taketomi,¹ S. Todo,⁴ K. Yamashita.³
¹Gastroenterological Surgery1, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ²Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ³Department of Transplant Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ⁴St Mary's Hospital, Kurume, Japan.
Background: Islet graft loss caused by injurious inflammatory and innate immune responses, is a major obstacle in pancreatic islet transplantation (PIT). In this pathophysiology, the…
2015 American Transplant Congress
Expression Patterns of Neuropilin-1 On T Cells and a Potential Role in Transplantation
E. Lee, H. Kim, G. Demirci.
Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA.
Introduction: Neuropilin-1 (NRP1) is a co-receptor for a variety of ligand families including VEGF, EGF and semaphorins all of which are often produced by malignant…
2015 American Transplant Congress
Recipient IL-33 Promotes Type 1 Alloimmunity and Lethal Acute GVHD Following alloHCT
B. Matta,¹ D. Reichenbach,² V. Schwarze,³ V. Tkachev,⁴ L. Mathews,¹ Q. Liu,¹ M. Warncke,⁵ J. Ferrara,⁴ R. Zeiser,³ B. Blazar,² H. Turnquist.¹
¹Surgery, Univ. of Pittsburgh, Pittsburgh, PA; ²Pediatrics, Univ. of Minnesota, Minneapolis, MN; ³Hematology and Oncology, Univ. Medical Center Freiburg, Freiburg, Germany; ⁴Pediatrics, Univ. of Michigan, Ann Arbor, MI; ⁵Novartis Institute for Biomedical Research, Basel, Switzerland.
Background: Graft-versus-host disease (GVHD) is a common complication of allogeneic (allo) hematopoietic cell transplantation (HCT) that limits its widespread application for the induction of transplant…
2015 American Transplant Congress
Mesenchymal Stem Cells Prevent Cold Ischemia-Reperfusion Injury in Lung Transplants
H. Wang,^1,2 W. Tian,¹ Y. Liu,³ X. Dai,¹ G. Li,³ T. Liu,^1,2 Z. Zhang,^1,2 C. Du.⁴
¹Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China; ²Tianjin General Surgery Institute, Tianjin, China; ³Department of Biology, Tianjin Medical University, Tianjin, China; ⁴Department of Urologic Sciences, The University of British Columbia, Vancouver, BC, Canada.
Background: Cold ischemia-reperfusion injury (IRI) is a major cause of graft failure in lung transplantation. Despite therapeutic benefits of mesenchymal stem cells (MSCs) in attenuating…
2015 American Transplant Congress
Myeloid Cell-Specific Heme Oxygenase-1 Is Crucial for Hepatoprotection in Liver Ischemia-Reperfusion Injury
K. Nakamura,¹ M. Zhang,² B. Ke,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.
Background and Aim: Heme oxygenase-1 (HO-1), an anti-oxidant enzyme, is essential in tissue resistance against innate immunity driven ischemia-reperfusion injury (IRI). Our group was the…
2015 American Transplant Congress
Effects of Toll Like Receptor (TLR) Signaling on Murine Alloimmunity Are Modulated by Immune Cell Derived Complement
J. Sheen, P. Heeger.
Translational Transplant Research Center, Department of Medicine and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
TLR signals prevent CD40L-blockade (MR1) induced murine transplant tolerance but mechanisms are incompletely understood. Based on previous findings that immune cell derived complement activation products…