Articles tagged "Mice"

2015 American Transplant Congress
Blocking CD40/CD154 Co-Stimulation Prevents Acute Antibody-Mediated Renal Allograft Rejection Induced by Memory CD4 T Cells
V. Gorbacheva, R. Fan, A. Valujskikh.
Immunology, The Cleveland Clinic, Cleveland, OH.
Immunosuppression-resistant alloreactive memory CD4 T cells induce robust responses against organ transplants. In murine heart allograft recipients donor-reactive memory CD4 T cells provide help for…
2015 American Transplant Congress
ALDH Expression in Facilitating Cells Plays a Critical Role in Regulatory T Cell Induction and GVHD Prevention
H. Xu,¹ T. Miller,¹ Y. Huang,¹ S. Ildstad.^1,2
¹Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; ²Regenerex, LLC, Louisville, KY.
Graft-vs-host disease (GVHD) is a major source of morbidity in hematopoietic stem cell transplantation (HSCT), limiting its application to treat nonmalignant hematopoietic diseases and to…
2015 American Transplant Congress
Altered Intestinal Microbiome as a Potential Biomarker for Failed Immune-Regulation in Autoimmune Type 1 Diabetes Mellitus
P. Chhabra,¹ A. Spano,² D. Bowers,¹ M. Wu,² L. Langman,¹ M. Timko,² K. Brayman.¹
¹Department of Surgery, University of Virginia, Charlottesville, VA; ²Department of Biology, University of Virginia, Charlottesville, VA.
Purpose: Beta-cell destruction results due to a failure of immune-regulation in type 1 diabetes (T1D). We investigated alterations in the intestinal microbiome composition as a…
2015 American Transplant Congress
Impact of CXCR4/CXCL12 Blockade on Normal Plasma Cells In Vivo
N. Moore,¹ M. Moreno Gonzales,² M. Stegall.¹
¹Department of Surgery, Division of Transplant Surgery and Department of Immunology, Mayo Clinic, Rochester, MN; ²Department of Surgery, Division of Transplant Surgery, Mayo Clinic, Rochester, MN.
Receptor/ligand interactions in stromal microenvironments play important roles in the localization, development and survival of normal antibody-secreting plasma cells. The goal of the current study…
2015 American Transplant Congress
B Cell Depletion With an Anti-CD20 Antibody Enhances Alloreactive Memory T Cell Response After Transplantation
J. Marino, P. Crosby Bertorini, J. Paster, A. Trowell, K. Briggs, L. Maxwell, G. Benichou.
Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA.
Pre-transplant B cell depletion in NHP with Rituximab (IgG1 anti-CD20 mAb) combined with cyclosporin A has been shown to promote the survival of islets allografts.…
2015 American Transplant Congress
Cell Type of the Tolerizing Inoculum Plays a Role in the Formation of of Molecular Chimerism in Murine Neonatal Tolerance
X. Wang,¹ H. Mewhort,¹ S. Wang,¹ S. Tollenaar,¹ K. Tao,¹ L. West.^1,2,3
¹Department of Pediatrics, University of Alberta, Edmonton, AB, Canada; ²Department of Surgery, University of Alberta, Edmonton, AB, Canada; ³Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada.
Background: Heart transplantation is a lifesaving measure for many infants with severe congenital heart diseases. The acceptance of cardiac allografts without immunosuppression, or operational tolerance,…
2015 American Transplant Congress
Combined Anti-IL6R and CTLA4Ig Therapy Attenuates Recall Alloantibody Responses in a Mouse Model of HLA Sensitization
N.-N. Chai, G. Wu, I. Kim, A. Klein, S. Jordan.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
[bald]Background[/bald] We previously reported that IL-6 inhibition by anti-IL6R antibody (mMR16-1) or CD28 pathway inhibition using CTLA4Ig (abatacept) reduced recall alloantibody responses in a mouse…
2015 American Transplant Congress
Eomes-Expressing CD8+ T Cells and Th17 Cells Mediate Costimulatory Blockade-Resistant Allograft Rejection in Mice
M. Sabet-Baktach,¹ E. Eggenhofer,¹ P. Renner,¹ M. Lantow,¹ H. Schlitt,¹ E. Geissler,¹ A. Kroemer.^1,2
¹Department of Surgery, University Hospital Regensburg, Regensburg, Germany; ²Georgetown Transplant Institute, Georgetown Transplant Institute, Washington, DC.
The etiology of costimulatory blockade-resistant allograft rejection remains unclear. Therefore, the purpose of this study was to evaluate the responsiveness of distinct CD4+ and CD8+…
2015 American Transplant Congress
CD8⁺TCR^– Bone Marrow Facilitating Cells Prime Migration and Enhance Homing of Hematopoietic Stem and Progenitor Cells
Y. Wen,¹ Y. Huang,¹ T. Miller,¹ S. Ildstad.^1,2
¹Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; ²Regenerex, LLC, Louisville, KY.
We recently reported the induction of chimerism and tolerance to renal allografts without GVHD or engraftment syndrome in HLA-mismatched living donor renal transplant recipients through…
2015 American Transplant Congress
Donor Dendritic Cells – Potential New Therapeutic Target in Transplantation
T. Ueno,^1,2,3 M. Yeung,¹ M. McGrath,¹ H. Iwamoto,³ Y. Nakamura,³ O. Konnno,³ Y. Kihara,³ T. Yokoyama,³ S. Ono,³ T. Ikeda,³ S. Kawachi,³ B. Ibrahim,¹ A. Chandraker.¹
¹Renal, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ³Transplant Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan.
Background: It is clear that T cells play a central role in the process of allograft rejection. However, donor dendritic cells (dDC) are the most…