Articles tagged "Mice"

2015 American Transplant Congress
Upregulation of Heart Transplant IL-33 Is Critical in Cardiac Tissue Repair
Q. Liu, L. Mathews, J. Lott, B. Matta, H. Turnquist.
Starzl Transplantation Institute, Department of Surgery, Univ of Pittsburgh, Pittsburgh, PA.
Background: IL-33 is tissue-derived cytokine whose primary proposed function is to modulate immune responses when released during injury. Delivery of recombinant IL-33 protects cardiac allografts…
2015 American Transplant Congress
Mesenchymal Stromal Cells (MSCs) Given Post-Transplant Together With C3a and C5a Receptor Antagonists Prevent Engraftment Syndrome and Induce a Mild Not-Significant Prolongation of Graft Survival
F. Casiraghi,¹ M. Todeschini,¹ N. Azzollini,¹ P. Cravedi,² P. Heeger,² P. Cassis,¹ S. Solini,¹ N. Perico,¹ M. Noris,¹ G. Remuzzi.¹
¹IRCSS Mario Negri Institute, Bergamo, Italy; ²Icahn School of Medicine at Mount Sinai, New York, NY.
Bone marrow (BM)-derived MSC given the day before kidney allografts localize into lymphoid organs and induce significant prolongation of graft survival in mice. By contrast,…
2015 American Transplant Congress
Lymphatic Endothelium Uniquely Enhances T Cell Migration to S1P
C. Brinkman, Y. Xiong, J. Bromberg.
University of Maryland, Baltimore, MD.
Introduction: Sphingosine-1-phosphate (S1P) is a signaling sphingolipid that regulates cell egress from lymphoid and non-lymphoid tissues. While S1P has been described as a chemoattractant, its…
2015 American Transplant Congress
Immunological Aspects of Iron Overload in Heart and Kidney Transplantation
T. Resch,¹ S. Ebner,¹ P. Ritschl,¹ M. Ashraf,¹ C. Fabritius,¹ A. Brunner,² V. Nguyen,¹ J. Günther,¹ J. Pratschke,³ K. Kotsch.¹
¹Department of Surgery, Medical University Innsbruck, Innsbruck, Austria; ²Department of Pathology, Medical University Innsbruck, Innsbruck, Austria; ³Department of Surgery, Charité, Berlin, Germany.
Background: Clinical data suggest that iron (Fe) overload deleteriously affects graft survival after heart (HTX) and kidney transplantation (KTX) but possible immunologic mechanisms underlying this…
2015 American Transplant Congress
Liver Versus Kidney. A Functional Study on Pancreatic Islet Implantation Sites
T. Corsello,¹ G. Curcuru,² D. Zorzi,³ M. Montalbano,¹ B. Carr,¹ L. Cicalese,¹ C. Rastellini.¹
¹Surgery, UTMB, Galveston, TX; ²Bioingegneria, Univ. of Palermo, Palermo, Sicilia, Italy; ³Surgical Oncology, MD Anderson, Houston, TX.
Background: In the clinical setting, liver is the site currently used for pancreatic islet transplantation (ITX). However, it has been shown that over 50% of…
2015 American Transplant Congress
Damage Associated Molecular Patterns (DAMPs)-Activated Neutrophil Extracellular Trap Formation Exacerbates Liver Ischemia/Reperfusion Injury
H. Huang, S. Tohme, A. Al-Khafaji, A. Tsung.
Department of Surgery, University of Pittsburgh, Pittsburgh, PA.
Liver ischemia/reperfusion (I/R) injury is a clinically important phenomenon encountered during transplantation that contributes to initial graft function and subsequent allograft rejection. Formation of neutrophil…
2015 American Transplant Congress
In Vivo Expansion of Donor-Specific Regulatory T Cells by a New Triazolopyrimidine Derivative and Donor-Specific Transfusion
S. Emoto,¹ R. Goto,¹ S. Shibasaki,¹ A. Nagatsu,¹ H. Ono,¹ R. Igarashi,¹ M. Fukai,² T. Shimamura,³ K. Saiga,⁴ M. Murakami,⁵ A. Taketomi,¹ S. Todo,⁶ K. Yamashita.²
¹Gastroenterological Surgery 1, Hokkaido University, Sapporo, Japan; ²Transplant Surgery, Hokkaido University, Sapporo, Japan; ³Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan; ⁴Nippon Kayaku, Tokyo, Japan; ⁵Institute for Genetic Medecine, Hokkaido University, Sapporo, Japan; ⁶Research Institute, St. Mary Hospital, Kurume, Japan.
Background: We have previously demonstrated that a new triazolopyrimidine derivative, NK026680 (NK) prevents activation/maturation of dendritic cells. This study investigated whether NK together with donor-specific…
2015 American Transplant Congress
Evaluation of the Gastrointestinal Tract as a Potential Route of Primary Polyomavirus Infection
G. Huang,¹ G. Zeng,² Y. Huang,² P. Randhawa.²
¹Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; ²Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.
Detection of Polyomavirus(Py) DNA in metropolitan river water worldwide has led to the suggestion that primary viral infection can occur by the oral route. The…
2015 American Transplant Congress
Ischemia-Induced Endoplasmic Reticulum Stress Regulates Autophagy to Determine the Severity of Liver Ischemia Reperfusion Injury
H. Zhou,^1,2 J. Zhu,¹ S. Yue,¹ R. Busuttil,¹ J. Kupiec-Weglinski,¹ Y. Zhai.¹
¹The Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA; ²Liver Transplant Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Both endoplasmic reticulum (ER) stress and autophagy have been implicated in the pathogenesis of ischemia and reperfusion injury (IRI). As essential cellular stress responses against…
2015 American Transplant Congress
Interleukin-17 Deficiency Attenuates Renal Allograft Injury and Prolongs Survival in a Murine Transplantation Model
T. Kwan,^1,2 S. Chadban,^1,2 J. Ma,^1,2 S. Bao,^2,3 S. Alexander,^2,4 H. Wu.^1,2
¹Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; ²Renal Medicine, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; ³Discipline of Pathology, School of Medical Sciences, Sydney, New South Wales, Australia; ⁴Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Aim:To investigate the role of IL-17 in allograft rejection using a murine model of fully MHC-mismatched renal transplantation.Methods:Life-sustaining kidney transplants were performed in nephrectomized mice:…