Articles tagged "Mice"

2017 American Transplant Congress
Macrophage Specific Deletion of RhoA Inhibits Fractalkine Signaling and Abrogates Chronic Rejection of Cardiac Allograft.
M. Kloc, Y. Liu, W. Chen, X. Li, R. Ghobrial.
Surgery, Houston Methodist Hospital and Research Institute, Houston
Objective. Chronic rejection of transplanted organs remains unresolved issue in organ transplantation. The chronic rejection is the most common cause of graft loss within 10…
2017 American Transplant Congress
CD4 T Cell Depletion Mitigates Ischemic Hepatocellular Damage and Promotes Immune Regulation in Mouse Liver Allografts.
S. Kageyama, K. Nakamura, R. Busuttil, J. Kupiec-Weglinski, Y. Zhai.
The Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, CA
Background: Extended cold preservation contributes to organ ischemia-reperfusion injury (IRI), which stimulates host allo-reactivity, leading to inferior clinical outcomes. We have shown that CD4+ T…
2017 American Transplant Congress
A Novel MyD88 Inhibitor Attenuates Allograft Rejection in Heterotopic Tracheal Transplantation in Mice.
M. Yang, X. Zhang, G. Chen, Z.-C. Ding, Y. Miao, Y. Yang, P. Zhou.
Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technolog; Key Lab of Ministry of Education & Ministry of Health of China, Wuhan, Hubei, China
Background: Obstructive bronchiolitis (OB) characterized by chronic rejection, is the main complication after lung transplantation which limits the long-term survival of the recipients. Innate immune…
2017 American Transplant Congress
HLA-DR Based Murine Transplant Model for Studying Collagen Type V Autoimmunity in Chronic Allograft Rejection.
V. Agashe, Y. Zhou, E. Jankowska-Gan, W. Burlingham.
Dept. of Surgery/Transplant Division, UW Madison, Madison, WI
Background: In lung and heart transplant patients, chronic rejection manifests as fibro-obliteration of airways and vessels resulting in bronchiolitis obliterans syndrome (BOS) or cardiac allograft…
2017 American Transplant Congress
Enhanced Liver Regeneration After Partial Hepatectomy in Mice Treated with a Prolyl Hydroxylase Inhibitor.
J. Latona,¹ A. Shah,¹ J. Cheng,² P. Messersmith,² E. Heber-Katz.³
¹Thomas Jefferson University, Philadelphia, PA; ²University of California, Berkeley, Berkeley, CA; ³Lankenau Institute for Medical Research, Wynnewood, PA
Purpose: Resection of more than 70% of liver mass increases incidence of post-operative hepatic failure due to an inability of the liver remnant to adequately…
2017 American Transplant Congress
A-Antigen (Ag)-Specific Tolerance Following A-Ag Administration to Infant Mice.
B. Motyka,¹ Y. Wang,¹ B. Lamarche,¹ I. Adam,¹ J. Pearcey,¹ K. Tao,¹ C. Cairo,² P. Cowan,³ L. West.¹
¹Dept Pediatrics, Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, Canada; ²Dept Chemistry, Alberta Glycomics Centre, University of Alberta, Edmonton, Canada; ³Immunology Research Centre, St Vincent's Hospital, University of Melbourne, Melbourne, Australia
Purpose: In contrast to adults, ABO-incompatible heart transplantation (ABOi HTx) can safely be performed in infants due to absent/low levels of anti-A/B antibodies (Ab). Tolerance…
2017 American Transplant Congress
Abrogating MyD88 Signaling in Donor Lung Resident Hematopoietic Cells Promotes Cell Based Tolerance Induction in Lung Allografts in Mice.
Z. Zheng,¹ J. Wang,¹ X. Yeap,¹ L. Li,³ L. Zhang,² M. He,¹ X. Luo,² Z. Zhang.¹
¹Comprehensive Transplant Center and Department of Surgery, Chicago, IL; ²Division of Nephrology and Hypertension, Chicago, IL; ³Department of Pathology, Chicago, IL
Objectives: MyD88 signaling plays an important role in allograft rejection and tolerance induction. This study is designed to determine the cellular base of MyD88 expression…
2017 American Transplant Congress
A Promising MyD88 Inhibitor TJ-M2010-2 Protects Heart from Myocardial Ischemia Reperfusion Injury.
Y. Miao, L. Xie, X. Zhang, Z.-C. Ding, M. Yang, Y. Yang, P. Zhou.
Institute of Qrgan Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Key Labrory of Organ Transplantation, Wuhan, Hubei, China
BACKGROUND: The activation of innate immunity via myeloid differentiation factor 88 (MyD88) contributes to myocardial ischemia reperfusion injury (IRI). This study is to investigate the…
2017 American Transplant Congress
Liver Targeted Expression of a Single Allogeneic MHC I Molecule Promotes Tolerance to Pancreatic Islet Allograft by Inducing Specific CD8+ Regulatory T Cells in Mice.
V. Le Guen,^1,2 J.-P. Judor,^1,2 V. Gauttier,^1,2 N. Ferry,³ J.-P. Soulillou,^1,2 S. Brouard,^1,2 S. Conchon.^1,2
¹Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France; ²Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; ³Département de Thérapie Cellulaire, CHU Saint Louis, Paris, France
A. Induction of donor-specific immune tolerance is a good alternative to chronic life-long immunosuppression for transplant patients. Donor major histocompatibility complex (MHC) molecules represent the…
2017 American Transplant Congress
CTLA4Ig Suppresses Memory Responses to HLA-A2⁺ Skin Grafts in a Mouse Model of Allosensitization by Reducing CD138⁺ Plasma Cells.
G. Wu, I. Kim, N.-N. Chai, S. Jordan, A. Klein.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Purpose: In previous studies we demonstrated that CTLA4Ig suppresses de novo T-cell activation through blocking CD28 co-stimulation and attenuates recall alloantibody responses following re-exposure to…