2018 American Transplant Congress
Recipient Conditioning Results in IL-33 Support of Potent Th1 Alloimmune Responses after CD4+ T Cells Upregulate ST2 during Lymphopenia Induced Proliferation
Purpose: IL-33 is typically associated with support of Th2 and Treg responses. Yet, recipient conditioning before allogeneic hematopoietic cell transplantation (alloHCT) releases IL-33 to promote…2017 American Transplant Congress
Dendritic Cell Expression of Rictor (mTORC2), but Not Raptor (mTORC1), Protects Against Renal Ischemia-Reperfusion Injury.
Background: Dendritic cells (DC) are critical initiators of innate immunity in the kidney and orchestrate inflammation subsequent to ischemia-reperfusion injury (IRI). The mechanistic target of…2017 American Transplant Congress
Targeting JAK-STAT Pathways with Tofacitinib Provides a Novel Approach for Conditioning in Allogeneic BMT Recipients.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY
Hematopoietic chimerism achieved by bone marrow transplantation (BMT) induces donor-specific tolerance to solid organ grafts. We previously demonstrated that by targeting recipient immune cells (T,…2017 American Transplant Congress
Improved Mouse Renal Transplantation Model Simulating Clinical Antibody Mediated Rejection.
Background: Acute antibody mediated rejection (AMR) is main barrier to long term renal graft survival. Mouse model is important to understand the mechenisms of AMR.…2017 American Transplant Congress
CTLA4-Ig Inhibits Effector CD8+ T Cell Function In Vivo and Rescues Ongoing Acute Allograft Rejection.
1Surgery, University of Chicago, Chicago, IL; 2Medicine, University of Chicago, Chicago, IL
CLTA4-Ig is clinically approved for preventing rejection in kidney transplant recipients but current data suggest that it is less effective for memory T cells, and…2017 American Transplant Congress
Dexamethasone Prolongs Cardiac Allograft Survival in a Murine Model Through Myeloid-Derived Suppressor Cells.
Recently, myeloid-derived suppressor cells (MDSCs) have attracted considerable attention because of their cancer-promoting and immunosuppressive effects. The glucocorticoid (GC) dexamethasone (Dex) is an important immunosuppressive…2017 American Transplant Congress
Differential Suppressive Effects of Costimulatory Blockade (CD28/B7), Anti-IL6R, Bruton's Tyrosine Kinase and Janus Kinase Inhibition on De Novo vs. Recall Alloantibody Responses: Are Combined Drug Therapy Approaches Desirable?
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Purpose: Preformed and de novo donor specific antibodies (DSA) contribute significantly to demise of allograft functions. There is no approved therapies for prevention or treatment…2017 American Transplant Congress
TIM-4 Identifies Pro-Inflammatory B Effector Cells That Are Potent Drivers of Alloimmunity and Allograft Rejection Through Expression of Both IFN-γ and IL-17.
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh
B cells can either augment or inhibit immune responses due to the presence both regulatory (Bregs) and effector (Beff) B cells expressing anti- or pro-…2017 American Transplant Congress
Short-Term Combination Treatment of FK506 and Anti-CD40 Ligand Remarkably Prolong Allograft Survival Time in Mouse Skin Transplantation.
Background: It is well established that skin are more prone than kidney to rejection after transplantation and is difficult to archive allograft acceptance following normal…2017 American Transplant Congress
Toll-Like Receptor 4-Dependent CCAAT-Enhancer-Binding Protein Homologous Protein Activation Induces Hepatocellular Cell Death in Liver Ischemia and Reperfusion Injury.
Background: Critical role of Toll-like receptor 4(TLR4) and endoplasmic reticulum (ER) stress has been found in ischemia and reperfusion(IR) injury models. However, the relationship between…
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