Articles tagged "Mice, knockout"

2019 American Transplant Congress
S1PR1 and S1PR4 Regulate T Cell Migration into Afferent Lymphatics
Y. Xiong¹, W. Piao¹, C. Brinkman¹, L. Li¹, J. Kulinski², A. Olivera², A. Cartier³, T. Hla⁴, K. Hippen⁵, B. Blazar⁶, S. Schwab⁷, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²NIH, Bethesda, MD, ³Boston Children's hospital, Boston, MA, ⁴Boston Children's, Boston, MA, ⁵U.Minnesota, Minneapolis, MN, ⁶U.Minnesota, Minneapolis, MD, ⁷NYU, NY, NY
*Purpose: T cells utilize S1PR1 to traffic from thymus into blood, and lymph nodes (LN) into efferent lymphatics. Whether T cell S1PR1 and S1PR4 regulate…
2019 American Transplant Congress
Depleting Laminin α5 in Lymph Node Stromal Cells Promotes Transplant Tolerance
L. Li, M. Shirkey, W. Piao, Y. Xiong, V. Saxena, T. Zhang, N. Toney, C. Paluskievicz, J. S. Bromberg
Surgery, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Expression of stromal laminin α5β1γ1 (511) in lymph nodes (LN) is associated with immunity, while laminin α4β1γ1 (411) is associated with tolerance. The laminins…