Articles tagged "Mice, knockout"

2019 American Transplant Congress
Treg Lymphotoxin and Lymphatic Endothelial Cell Lymphotoxin Receptor Interactions Are Required for Treg Stability and Allograft Protection
V. Saxena, W. Piao, L. Li, C. M. Palusckievicz, Y. Xiong, T. Simon, J. S. Bromberg
U Maryland, Baltimore, MD
*Purpose: Regulatory T cells (Treg) restrain allograft rejection through suppressor functions that are dependent upon expression of the transcription factor Foxp3, their proper migration, and…
2019 American Transplant Congress
S1PR1 and S1PR4 Regulate T Cell Migration into Afferent Lymphatics
Y. Xiong¹, W. Piao¹, C. Brinkman¹, L. Li¹, J. Kulinski², A. Olivera², A. Cartier³, T. Hla⁴, K. Hippen⁵, B. Blazar⁶, S. Schwab⁷, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²NIH, Bethesda, MD, ³Boston Children's hospital, Boston, MA, ⁴Boston Children's, Boston, MA, ⁵U.Minnesota, Minneapolis, MN, ⁶U.Minnesota, Minneapolis, MD, ⁷NYU, NY, NY
*Purpose: T cells utilize S1PR1 to traffic from thymus into blood, and lymph nodes (LN) into efferent lymphatics. Whether T cell S1PR1 and S1PR4 regulate…