2020 American Transplant Congress
Ifnar Signaling on Myeloid Cells Does Not Contribute to Costimulation Independent Transplant Rejection
*Purpose: Costimulation blockade (CoB) is a promising new strategy that provides a more targeted therapy with fewer side effects compared to traditional transplant immunosuppressants, leading…2020 American Transplant Congress
TGR5/Cathepsin E Signaling Regulates Macrophage Innate Immune Activation in the Sterile Inflammatory Liver Injury
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: The hepatic proinflammatory response represents a major cause of liver ischemia and reperfusion (IR) injury. Although the role of plasma membrane-bound G protein-coupled bile…2020 American Transplant Congress
Treg Stability Depends on Lymphotoxin Beta Receptor-Driven Migration
University of Maryland, Baltimore, Baltimore, MD
*Purpose: Regulatory T cell (Treg) suppressor function for allograft survival requires maintenance of transcription factor Foxp3 and sequential migration from tissues to lymph nodes (LN).…2020 American Transplant Congress
Lymphotoxin Beta Receptor Regulates Draining Lymph Node Structure and Treg Migration
1University of Maryland, Baltimore, Baltimore, MD, 2Harvard U, Boston, MA
*Purpose: To induce tolerance, regulatory T cells (Treg) are required to migrate from tissues via afferent lymphatic vessels (LV) to the draining lymph node (dLN).…2020 American Transplant Congress
The Role of CXCL16/CXCR6 in Mediating Macrophage Chemotaxis and M1 Macrophage Polarization in Murine Renal Ischemia Reperfusion Injury
*Purpose: The objective of this study is to investigate the role of Chemokine (C-X-C motif) ligand 16 (CXCL16) and its unique receptor C-X-C chemokine receptor…2020 American Transplant Congress
Treg Protection of the Allograft Depends on Lymphotoxin Beta Receptor Expression in Lymphatic Endothelial Cells
1University of Maryland, Baltimore, Baltimore, MD, 2Harvard U, Boston, MA
*Purpose: Regulatory T cell (Treg) migration to afferent lymphatics and lymph nodes (LN), and suppressive function, require Treg lymphotoxin alpha (LTα) to stimulate LT beta-receptor…2020 American Transplant Congress
Novel Role of Qa-1, a Murine Homolog of HLA-E, in Controlling Follicular Helper T Cells During Humoral Alloimmunity
*Purpose: Antibody-mediated rejection (AMR) is a major challenge in prolonging allograft survival. Limited insight into the humoral alloimmunity hinders the development of therapeutic strategies. We…2020 American Transplant Congress
Cell-Free DNA (cfDNA) is Released by Necroptosis and Promotes Kidney Ischemia Reperfusion Injury
Microbiology and Immunology, Western University, London, ON, Canada
*Purpose: Transplantation is invariably associated with ischemia reperfusion injury (IRI) which causes organ dysfunction. IRI is also directly linked to several forms of programmed cell…2020 American Transplant Congress
Characterization of Laminin Alpha 4 Conditional Knockout Mice: Model for Immune Stimulation
*Purpose: Lymph node (LN) stromal laminin α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We created a Lama4 conditional knockout (KO)…2019 American Transplant Congress
Decay Accelerating Factor (DAF) Regulates Germinal Center B-cell and Alloantibody Formation
*Purpose: High affinity IgG antibodies including alloantibodies result from germinal center (GC) reactions in which somatic hypermutation and positive selection cause affinity maturation. When we…
American Transplant Congress abstracts