ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mice, knockout"

  • 2022 American Transplant Congress

    Deletion of Fibroblastic Reticular Cell Derived Laminin A4 Impairs Lymph Node Vasculature and Conduits

    L. Li1, M. Shirkey1, W. Piao1, A. Kensiski1, V. Saxena1, T. Zhang1, X. Li2, J. Zhao2, S. Gavzy1, R. Abdi2, J. Bromberg1

    1UMB, Baltimore, MD, 2Harvard University, Boston, MA

    *Purpose: Fibroblastic reticular cells (FRCs) support lymph node (LN) structure by producing various functional extracellular matrix (ECM) components. We hypothesized that FRCs and their ECM…
  • 2022 American Transplant Congress

    CD40 Expressed by FRC Regulates Lymph Node Structure and Function

    M. W. Shirkey1, L. Li1, R. Abdi2, J. S. Bromberg1

    1University of Maryland School of Medicine, Baltimore, MD, 2Transplant Research Center, Harvard Medical School, Boston, MA

    *Purpose: Fibroblastic reticular cells (FRC) support lymph node (LN) structure and can regulate T cell function through the CD40-CD40L pathway. Our previous work showed that…
  • 2021 American Transplant Congress

    Myeloid Foxo1-β-catenin Axis Regulates Hedgehog/Gli1 Signaling and Controls NLRP3-Mediated Innate Immune Responses in Sterile Inflammatory Liver Injury

    D. Xu, C. Li, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke

    Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA

    *Purpose: Foxo1 plays important roles in cell metabolism, oxidative stress, inflammation, and apoptosis. Activation of Hedgehog/Gli1 signaling regulates cell growth, differentiation, and immune function. However,…
  • 2021 American Transplant Congress

    Treg Engagement of Lymphotoxin Beta Receptor in Lymphatic Endothelial Cells is Required for Allograft Protection

    V. Saxena1, W. Piao1, L. Li1, Y. Xiong1, M. W. Shirkey1, J. Iyyathurai1, R. Lakhan1, R. Abdi2, J. Bromberg1

    1U Maryland, Baltimore, MD, 2Harvard U, Boston, MA

    *Purpose: Sequential migration of regulatory T cells (Treg) from graft to afferent lymphatics and lymph nodes (LN) is needed for Treg suppressive function. Migration requires…
  • 2021 American Transplant Congress

    LTβR Engagement Regulates Treg Migration, Stability and Suppressor Function

    V. Saxena1, W. Piao1, L. Li1, Y. Xiong1, M. W. Shirkey1, J. Iyyathurai1, R. Lakhan1, R. Abdi2, J. Bromberg1

    1U Maryland, Baltimore, MD, 2Harvard U, Boston, MA

    *Purpose: Regulatory T cell (Treg) lymphatic migration and maintenance of transcription factor Foxp3 expression are required for suppressor function and allograft protection. Treg stimulate lymphotoxin…
  • 2021 American Transplant Congress

    CEACAM1 Signaling is Essential to Elicit Tim-3 Inhibitory Regulation in Liver Transplantation

    H. Kojima, H. Hirao, T. Ito, K. Kadono, K. J. Dery, F. M. Kaldas, J. W. Kupiec-Weglinski

    The Dumont-UCLA Transplantation Center, Los Angeles, CA

    *Purpose: T cell immunoglobulin domain and mucin domain-3 (TIM-3) has been reported to induce T cell exhaustion. By alleviating hepatic ischemia-reperfusion injury, we have explored…
  • 2021 American Transplant Congress

    Laminins Differentially Regulate Adaptive Alloimmune Responses

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena1, T. Zhang1, J. Iyyathurai2, R. Lakhan1, R. Abdi3, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2CVID, UMB, Baltimore, MD, 3Harvard University, Boston, MA

    *Purpose: Lymph node (LN) stromal cell expressed laminin α4 (Lama4) and laminin α5 (Lama5) fibers are associated with tolerance and immunity, respectively. They regulate cell…
  • 2021 American Transplant Congress

    Lymphotoxin Beta Receptor Regulates Treg Migration and Suppression by Modulating Draining Lymphatic Structure

    V. Saxena1, W. Piao1, L. Li1, M. W. Shirkey1, J. Iyyathurai1, R. Lakhan1, R. Abdi2, J. Bromberg1

    1U Maryland, Baltimore, MD, 2Harvard U, Boston, MA

    *Purpose: Regulatory T cells (Treg) must migrate from tissues via lymphatic vessels (LV) to the draining lymph node (dLN) to induce tolerance. During migration, Treg…
  • 2021 American Transplant Congress

    The Hepatoprotective Role of Innate Lymphoid Cells in Liver Transplantation

    H. Kojima, H. Hirao, H. Zhang, K. Kadono, K. J. Dery, Y. Zhai, J. Kupiec-Weglinski

    The Dumont-UCLA Transplantation Center, Los Angeles, CA

    *Purpose: Although NKp46+group 3innate lymphoid cells (ILCs) (RORγt+IL-22-producing NKp46+cells) were reported to protect liver against ischemia-reperfusion injury (IRI), no study has demonstrated the contribution of…
  • 2020 American Transplant Congress

    Lymphotoxin Beta Receptor Regulates Draining Lymph Node Structure and Treg Migration

    V. Saxena1, W. Piao1, L. Li1, Y. Xiong1, C. C. Palusckievicz1, T. Simon1, M. W. Shirkey1, R. Abdi2, J. S. Bromberg1

    1University of Maryland, Baltimore, Baltimore, MD, 2Harvard U, Boston, MA

    *Purpose: To induce tolerance, regulatory T cells (Treg) are required to migrate from tissues via afferent lymphatic vessels (LV) to the draining lymph node (dLN).…
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