2022 American Transplant Congress
Axl and MerTK Regulate the Activation of Liver Ischemia Reperfusion Injury by Upregulating Il-13 in Kupffer Cells
*Purpose: Ischemia reperfusion injury (IRI) remains an unresolved clinical problem. A sterile inflammatory response drives the disease pathogenesis. Although mechanisms of liver innate immune activation…2022 American Transplant Congress
Recipient Treatment with Anti-CD122 mAb Prolongs Kidney Allograft Survival During Antibody-Mediated Rejection without Impacting NK Cell Activation within the Graft
Cleveland Clinic, Cleveland, OH
*Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched kidney allografts and are required for rejection of the…2021 American Transplant Congress
Myeloid Foxo1-β-catenin Axis Regulates Hedgehog/Gli1 Signaling and Controls NLRP3-Mediated Innate Immune Responses in Sterile Inflammatory Liver Injury
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: Foxo1 plays important roles in cell metabolism, oxidative stress, inflammation, and apoptosis. Activation of Hedgehog/Gli1 signaling regulates cell growth, differentiation, and immune function. However,…2021 American Transplant Congress
Treg Engagement of Lymphotoxin Beta Receptor in Lymphatic Endothelial Cells is Required for Allograft Protection
1U Maryland, Baltimore, MD, 2Harvard U, Boston, MA
*Purpose: Sequential migration of regulatory T cells (Treg) from graft to afferent lymphatics and lymph nodes (LN) is needed for Treg suppressive function. Migration requires…2021 American Transplant Congress
LTβR Engagement Regulates Treg Migration, Stability and Suppressor Function
1U Maryland, Baltimore, MD, 2Harvard U, Boston, MA
*Purpose: Regulatory T cell (Treg) lymphatic migration and maintenance of transcription factor Foxp3 expression are required for suppressor function and allograft protection. Treg stimulate lymphotoxin…2021 American Transplant Congress
CEACAM1 Signaling is Essential to Elicit Tim-3 Inhibitory Regulation in Liver Transplantation
The Dumont-UCLA Transplantation Center, Los Angeles, CA
*Purpose: T cell immunoglobulin domain and mucin domain-3 (TIM-3) has been reported to induce T cell exhaustion. By alleviating hepatic ischemia-reperfusion injury, we have explored…2021 American Transplant Congress
Laminins Differentially Regulate Adaptive Alloimmune Responses
1Surgery, UMB, Baltimore, MD, 2CVID, UMB, Baltimore, MD, 3Harvard University, Boston, MA
*Purpose: Lymph node (LN) stromal cell expressed laminin α4 (Lama4) and laminin α5 (Lama5) fibers are associated with tolerance and immunity, respectively. They regulate cell…2021 American Transplant Congress
Lymphotoxin Beta Receptor Regulates Treg Migration and Suppression by Modulating Draining Lymphatic Structure
1U Maryland, Baltimore, MD, 2Harvard U, Boston, MA
*Purpose: Regulatory T cells (Treg) must migrate from tissues via lymphatic vessels (LV) to the draining lymph node (dLN) to induce tolerance. During migration, Treg…2021 American Transplant Congress
The Hepatoprotective Role of Innate Lymphoid Cells in Liver Transplantation
The Dumont-UCLA Transplantation Center, Los Angeles, CA
*Purpose: Although NKp46+group 3innate lymphoid cells (ILCs) (RORγt+IL-22-producing NKp46+cells) were reported to protect liver against ischemia-reperfusion injury (IRI), no study has demonstrated the contribution of…2020 American Transplant Congress
Role of Circulating Exosomes in the Induction of Immune Responses Resulting in Cardiac Allograft Rejection in miR155 Knockout Animals
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Our goal is to define the mechanism by which circulating exosomes with cardiac self-antigens (SAgs), Myosin, Vimentin, and angiotensin Receptor 1 Protein (AGTR1) leads…
American Transplant Congress abstracts