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American Transplant Congress abstracts

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Articles tagged "Mice, knockout"

  • 2022 American Transplant Congress

    Early Il-33 Action on Myeloid Cells is Critical In Resistance to Systemic Candida Albicans Infection

    H. Cho1, S. Park1, B. Kwon2, H. Park1, Y. Kim3, J. Lee4, J. Park4, K. Park4, K. Yoo4

    1Department of Surgery, University of Ulsan College of Medicine, Ulsan, Korea, Republic of, 2School of Biological Sciences, University of Ulsan, Ulsan, Korea, Republic of, 3Biomedical research center, Ulsan University Hospital, Ulsan, Korea, Republic of, 4Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea, Republic of

    *Purpose: Invasive candidiasis could be a cause of morbidity and mortality in immunocompromised patients with organ or bone marrow transplantation. In this study, we systematically…
  • 2022 American Transplant Congress

    Atherosclerosis Reduces Anti-Tumor Activity of Liver-Resident Natural Killer Cells

    K. Imaoka, M. Ohira, K. Sato, Y. Imaoka, R. Nakano, H. Ohdan

    Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

    *Purpose: Abdominal aorta calcification (AAC) is associated with an increased relative risk of coronary events, cerebrovascular events, cardiovascular events, and cardiovascular death. We report that…
  • 2021 American Transplant Congress

    Treg Engagement of Lymphotoxin Beta Receptor in Lymphatic Endothelial Cells is Required for Allograft Protection

    V. Saxena1, W. Piao1, L. Li1, Y. Xiong1, M. W. Shirkey1, J. Iyyathurai1, R. Lakhan1, R. Abdi2, J. Bromberg1

    1U Maryland, Baltimore, MD, 2Harvard U, Boston, MA

    *Purpose: Sequential migration of regulatory T cells (Treg) from graft to afferent lymphatics and lymph nodes (LN) is needed for Treg suppressive function. Migration requires…
  • 2021 American Transplant Congress

    LTβR Engagement Regulates Treg Migration, Stability and Suppressor Function

    V. Saxena1, W. Piao1, L. Li1, Y. Xiong1, M. W. Shirkey1, J. Iyyathurai1, R. Lakhan1, R. Abdi2, J. Bromberg1

    1U Maryland, Baltimore, MD, 2Harvard U, Boston, MA

    *Purpose: Regulatory T cell (Treg) lymphatic migration and maintenance of transcription factor Foxp3 expression are required for suppressor function and allograft protection. Treg stimulate lymphotoxin…
  • 2021 American Transplant Congress

    CEACAM1 Signaling is Essential to Elicit Tim-3 Inhibitory Regulation in Liver Transplantation

    H. Kojima, H. Hirao, T. Ito, K. Kadono, K. J. Dery, F. M. Kaldas, J. W. Kupiec-Weglinski

    The Dumont-UCLA Transplantation Center, Los Angeles, CA

    *Purpose: T cell immunoglobulin domain and mucin domain-3 (TIM-3) has been reported to induce T cell exhaustion. By alleviating hepatic ischemia-reperfusion injury, we have explored…
  • 2021 American Transplant Congress

    Laminins Differentially Regulate Adaptive Alloimmune Responses

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena1, T. Zhang1, J. Iyyathurai2, R. Lakhan1, R. Abdi3, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2CVID, UMB, Baltimore, MD, 3Harvard University, Boston, MA

    *Purpose: Lymph node (LN) stromal cell expressed laminin α4 (Lama4) and laminin α5 (Lama5) fibers are associated with tolerance and immunity, respectively. They regulate cell…
  • 2021 American Transplant Congress

    Lymphotoxin Beta Receptor Regulates Treg Migration and Suppression by Modulating Draining Lymphatic Structure

    V. Saxena1, W. Piao1, L. Li1, M. W. Shirkey1, J. Iyyathurai1, R. Lakhan1, R. Abdi2, J. Bromberg1

    1U Maryland, Baltimore, MD, 2Harvard U, Boston, MA

    *Purpose: Regulatory T cells (Treg) must migrate from tissues via lymphatic vessels (LV) to the draining lymph node (dLN) to induce tolerance. During migration, Treg…
  • 2021 American Transplant Congress

    The Hepatoprotective Role of Innate Lymphoid Cells in Liver Transplantation

    H. Kojima, H. Hirao, H. Zhang, K. Kadono, K. J. Dery, Y. Zhai, J. Kupiec-Weglinski

    The Dumont-UCLA Transplantation Center, Los Angeles, CA

    *Purpose: Although NKp46+group 3innate lymphoid cells (ILCs) (RORγt+IL-22-producing NKp46+cells) were reported to protect liver against ischemia-reperfusion injury (IRI), no study has demonstrated the contribution of…
  • 2021 American Transplant Congress

    Myeloid Foxo1-β-catenin Axis Regulates Hedgehog/Gli1 Signaling and Controls NLRP3-Mediated Innate Immune Responses in Sterile Inflammatory Liver Injury

    D. Xu, C. Li, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke

    Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA

    *Purpose: Foxo1 plays important roles in cell metabolism, oxidative stress, inflammation, and apoptosis. Activation of Hedgehog/Gli1 signaling regulates cell growth, differentiation, and immune function. However,…
  • 2020 American Transplant Congress

    Novel Role of Qa-1, a Murine Homolog of HLA-E, in Controlling Follicular Helper T Cells During Humoral Alloimmunity

    J. Y. Choi1, S. K. Eskandari1, S. Cai1, J. Assaker1, I. Sulkaj1, H. Allos1, J. Alhaddad1, P. Chu1, H. Kim2, H. I. Cantor2, J. R. Azzi1

    1Medicine, Brigham and Women's Hospital, Boston, MA, 2Immunology, Dana Farber Cancer Institute, Boston, MA

    *Purpose: Antibody-mediated rejection (AMR) is a major challenge in prolonging allograft survival. Limited insight into the humoral alloimmunity hinders the development of therapeutic strategies. We…
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