2016 American Transplant Congress
Tracking Endogenous B Cells Recognizing Allogeneic MHC Class II in Mice.
Clinical data suggest that donor-specific antibody (DSA)-mediated rejection is currently the leading cause of kidney allograft failure, with anti-donor Class II Abs tending to be…2015 American Transplant Congress
Immunomodulatory Strategies Directed Towards Tolerance of Vascularized Composite Allografts
Background: Achieving tolerance of vascularized composite allografts (VCAs) would improve the risk-to-benefit ratio in patients who undergo this life-enhancing transplant. Kidney co-transplantation along with a…2015 American Transplant Congress
Microvascular Inflammation in Early Protocol Biopsies of Renal Allografts in Cases of Chronic Active Antibody-Mediated Rejection
Aim:Chronic active antibody-mediated rejection (chronic ABMR) is one important cause of late-stage renal allograft loss. However, few reports have used protocol biopsy to observe changes…2015 American Transplant Congress
Regulatory Tolerance Across a Full MHC Barrier Is More Robust Than Tolerance Across a Class I MHC Disparity Alone
Background: We previously demonstrated that tolerance of hearts and/or kidneys achieved across a class I MHC mismatch with 12 days of CyA can be abrogated…2015 American Transplant Congress
Donor MHC Independent Rejection of Islet Allografts in Autoimmune NOD Mice
In autoimmune Type 1 diabetes (T1D), pancreatic islet allografts have somewhat limited long-term survival, both in T1D human subjects and in spontaneously diseased non-obese diabetic…2015 American Transplant Congress
Highly Accurate High-Resolution HLA Imputation Using Dense Genotyping Data
HLA similarity between donors (D) and recipients (R) of solid organ transplantation (SOT) plays a central role in determining the risk of rejection or graft-versus-host…
American Transplant Congress abstracts