ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "MHC class II"

  • 2016 American Transplant Congress

    An In-Situ Treatment of Donor Skin Induces MARCH1 and Decreases MHC II Expression on Donor Dendritic Cells, Promoting Skin Allograft Acceptance.

    T. Borges,1,2 F. Machado,1 C. Bonorino,1 L. Riella.2

    1School of Biosciences and Biomedical Research Institute, PUCRS, Porto Alegre, RS, Brazil; 2Schuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

    Background: Skin transplants are the most immunogenic of all transplants and donor DCs play a crucial role in activating effector alloreactive T cells and initiating…
  • 2015 American Transplant Congress

    Microvascular Inflammation in Early Protocol Biopsies of Renal Allografts in Cases of Chronic Active Antibody-Mediated Rejection

    T. Tsuji,1 M. Yanai,1 H. Itami,1 Y. Ishii,1 M. Akimoto,1 N. Fukuzawa,2 H. Harada,2 Y. Fukasawa.1

    1Demartment of Pathology, Sapporo City General Hospital, Sapporo, Japan; 2Department of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan.

    Aim:Chronic active antibody-mediated rejection (chronic ABMR) is one important cause of late-stage renal allograft loss. However, few reports have used protocol biopsy to observe changes…
  • 2015 American Transplant Congress

    Regulatory Tolerance Across a Full MHC Barrier Is More Robust Than Tolerance Across a Class I MHC Disparity Alone

    M. Madariaga, S. Michel, G. La Muraglia II, M. O'Neil, W. Orent, V. Villani, M. Sekijima, E. Farkash, R. Colvin, J. Allan, K. Yamada, J. Madsen, D. Sachs.

    Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

    Background: We previously demonstrated that tolerance of hearts and/or kidneys achieved across a class I MHC mismatch with 12 days of CyA can be abrogated…
  • 2015 American Transplant Congress

    Donor MHC Independent Rejection of Islet Allografts in Autoimmune NOD Mice

    A. Burrack,1 K. Beard,2 M. Coulombe,2 R. Gill.2

    1Medicine, University of Minnesota, Minneapolis, MN; 2Surgery and Immunology, University of Colorado Denver, Aurora, CO.

    In autoimmune Type 1 diabetes (T1D), pancreatic islet allografts have somewhat limited long-term survival, both in T1D human subjects and in spontaneously diseased non-obese diabetic…
  • 2015 American Transplant Congress

    Highly Accurate High-Resolution HLA Imputation Using Dense Genotyping Data

    B. Keating,1 Y. Li,1 T. Guettouche,2 K. Olthoff,1 A. Shaked.1

    1Surgery (Division of Transplantation), University of Pennsylvania, Philadelphia, PA; 2Genetics, Children's Hospital of Philadelphia, Philadelphia, PA.

    HLA similarity between donors (D) and recipients (R) of solid organ transplantation (SOT) plays a central role in determining the risk of rejection or graft-versus-host…
  • 2015 American Transplant Congress

    Immunomodulatory Strategies Directed Towards Tolerance of Vascularized Composite Allografts

    M. Madariaga, K. Shanmugarajah, S. Michel, V. Villani, G. La Muraglia II, R. Torabi, D. Leonard, M. Randolph, R. Colvin, K. Yamada, J. Madsen, C. Cetrulo, Jr., D. Sachs.

    Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

    Background: Achieving tolerance of vascularized composite allografts (VCAs) would improve the risk-to-benefit ratio in patients who undergo this life-enhancing transplant. Kidney co-transplantation along with a…
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