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Articles tagged "MHC class II"

  • 2018 American Transplant Congress

    Feasibility of a National Class II Matching Strategy for Pediatric Kidney Transplant Candidates

    T. Blydt-Hansen,1 W. Klement,2 K. Tinckam,3 J. Gill.1

    1University of British Columbia, Vancouver, Canada; 2Canadian Blood Services, Ottawa, Canada; 3University of Toronto, Toronto, Canada.

    Antibody-mediated rejection (AMR) is a major concern for allograft failure, which could be mitigated by allocation of Class II matched donors. Since children have priority,…
  • 2017 American Transplant Congress

    MHC Class II-Peptide Complexes Displayed on Activated T Cells Guide Treg Suppression.

    M. Fryer, S. Junius, S. Germana, L. Turka, C. LeGuern.

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    Background: Regulatory T cell (Tregs) therapy remains a promising strategy for minimizing immunosuppression and extending allograft survival. Although Treg suppression requires initial activation through cell…
  • 2017 American Transplant Congress

    Contemporary Outcomes and Risk Factors of Acute Graft-versus-Host Disease After Liver Transplant.

    J. Markus, A. Bukannan, B. Kashat, R. Salgia.

    Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI

    Introduction:Acute graft-versus-host-disease (GVHD) is a rare complication of orthotopic liver transplant (LT) that has an estimated incidence of 0.1%-2% per year. This complication of OLT…
  • 2017 American Transplant Congress

    HLA Class II Molecules Partner with TLR4 to Stimulate Endothelial Cell Activation and Proliferation.

    Y.-P. Jin, E. Reed.

    Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA

    Background: Transplant recipients developing donor specific HLA antibodies (DSA) are at a higher risk for acute and chronic antibody-mediated rejection (AMR). DSA contribute to the…
  • 2017 American Transplant Congress

    Non-Human Primate Auto-Immune Responses to Col V, Kα-1Tubulin and Vimentin Are P2X7R Dependent.

    J. Sullivan,1 E. Jankowska-Gan,1 D. Kaufman,1 L. Denlinger,2 W. Burlingham.1

    1Surgery, University of Wisconsin, Madison, WI; 2Medicine, University of Wisconsin, Madison, WI

    Background: Auto-immune responses to Collagen type V (ColV) have been associated with coronary artery disease and lung or heart transplant rejection in humans and murine…
  • 2017 American Transplant Congress

    Development of Transplant Glomerulopathy in Recipients with Antibody Mediated Rejection: Activation of Inflammatory Pathway Through Renal Poly (ADP-Ribose) Polymerase (PARP).

    B. Ozdemir,1 F. Ozdemir,2 E. Baskin,2 M. Haberal.3

    1Pathology, Baskent University, Ankara, Turkey; 2Pediatric Nephrology, Baskent University, Ankara, Turkey; 3Transplant Surgery, Baskent University, Ankara, Turkey

    Activation of PARP is a critical factor in the pathogenesis of various inflammatory and fibrotic process. Thus we aimed to show the integral of PARP…
  • 2016 American Transplant Congress

    Is C3d-fixing Donor Specific HLA Antibody Detection Really Necessary?

    P. Malvezzi,1 M. Villemaire,1 A. Bourdin,2 T. Jouve,1 R. Tetaz,1 B. Janbon,1 N. Terrier,3 D. Masson.2

    1Service de Néphrologie, Grenoble University Hospital, Grenoble, France; 2Laboratoire d'Histocompatibilité, EFS, Grenoble, France; 3Service d'Urologie, Grenoble University Hospital, Grenoble, France.

    Introduction: Chronic antibody–mediated rejection is the main cause of late kidney graft loss. The identification of donor-specific antibodies (DSA) in the serum is one of…
  • 2016 American Transplant Congress

    Direct Alloimmunity Is Driven by Recipient APCs Displaying Donor MHC Molecules.

    J. Marino,1 J. Paster,1 P. Crosby,1 M. Uehara,2 S. Mordecai,1 R. Abdi,2 G. Tocco,1 G. Benichou.1

    1Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA; 2Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA.

    We have studied the trafficking of donor passenger leukocytes and donor MHC presentation in the lymphoid organs of mice having received an MHC-mismatched skin or…
  • 2016 American Transplant Congress

    An In-Situ Treatment of Donor Skin Induces MARCH1 and Decreases MHC II Expression on Donor Dendritic Cells, Promoting Skin Allograft Acceptance.

    T. Borges,1,2 F. Machado,1 C. Bonorino,1 L. Riella.2

    1School of Biosciences and Biomedical Research Institute, PUCRS, Porto Alegre, RS, Brazil; 2Schuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

    Background: Skin transplants are the most immunogenic of all transplants and donor DCs play a crucial role in activating effector alloreactive T cells and initiating…
  • 2016 American Transplant Congress

    HLA Class II and BK Virus Reactivation in Renal Transplant Recipients.

    P. Shah,1 K. Anderson,2 M. Aubrey,2 C. Roark,2 B. Freed,2 A. Wiseman.1

    1Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, CO; 2Division of Immunology, University of Colorado School of Medicine, Aurora, CO.

    BK Viremia (BKV) and subsequent BK nephropathy are associated with renal graft loss. The Human Leukocyte Antigen (HLA) region has been implicated in susceptibility to…
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