ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "MHC class II"

  • 2020 American Transplant Congress

    Can HLA-DQ Molecular Mismatch Analysis Be Used to Predict Generation of De Novo Donor-Specific Antibody at an Individual Patient Level?

    D. Pinelli1, M. Casillas Abundis1, R. Hod Dvorai2, H. McDowell1, A. R. Tambur1

    1Northwestern University, Chicago, IL, 2SUNY Upstate Medical University, Syracuse, NY

    *Purpose: De novo donor-specific antibodies (dnDSA), especially to HLA-DQ, are one of the leading causes of late kidney graft failure. Many investigators have attempted to…
  • 2020 American Transplant Congress

    Inflammatory Cytokines Have a Different Effect from One HLA-II Subclass to Another on Human Endothelium

    S. Beland, F. Bouchard-Boivin, A. Gama, O. Desy, S. A. De Serres

    Universite Laval, Quebec, QC, Canada

    *Purpose: Development of de novo donor-specific antibodies (DSAs) is associated with antibody-mediated rejection and allograft failure. More particularly, HLA-II DSAs, especially those against DQ are…
  • 2020 American Transplant Congress

    HLA Molecular Mismatch is an Independent Correlate of T-Cell Mediated Rejection and Potential Prognostic Biomarker in Renal Transplantation

    C. Wiebe1, D. Pochinco2, I. W. Gibson3, J. Ho1, P. Birk4, A. Goldberg4, M. Karpinski5, J. Shaw5, R. N. David5, P. W. Nickerson1

    1Medicine and Immunology, University of Manitoba, Winnipeg, MB, Canada, 2Shared Health Services, Winnipeg, MB, Canada, 3Pathology, University of Manitoba, Winnipeg, MB, Canada, 4Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada, 5Medicine, University of Manitoba, Winnipeg, MB, Canada

    *Purpose: HLA molecular mismatch alloimmune risk categorization has correlated with de novo donor-specific antibody (dnDSA) development, however, correlation with T-cell mediated rejection (TCMR) phenotypes is…
  • 2019 American Transplant Congress

    Upregulation of Endothelial HLA Class II as a Marker of Antibody Mediated Rejection in Heart Allograft Biopsies

    Q. Cai, Y. Butt, A. Hendricks, J. Torrealba

    Pathology, UTSW Medical Ctr, Dallas, TX

    *Purpose: In 2013, the ISHLT (International Society of Heart and Lung Transplant) introduced the working classification for pathological changes associated with antibody-mediated rejection of the…
  • 2019 American Transplant Congress

    Relationship between HLA-DPB1 Gene Expression in Pre-Implantation Kidney Biopsies, Rs9277534 Polymorphism, and Late Graft Function

    K. L. Mine1, T. B. Mourão1, C. Felipe2, G. F. Rampim1, J. O. Medina-Pestana2, H. Tedesco-Silva2, M. Gerbase-DeLima1

    1Immunogenetics Institute, Associação Fundo de Incentivo a Pesquisa - AFIP, Sao Paulo, SP, Brazil, 2Hospital do Rim, Sao Paulo, SP, Brazil

    *Purpose: A previous gene expression microarray study in pre-implantation biopsies (PIB) from kidneys of adult deceased donors (D) showed association between high class II HLA…
  • 2019 American Transplant Congress

    Targeted Epitope Mutagenesis as a Strategy to Decrease Xenoantibody Binding

    J. Ladowski, G. Martens, Z. Wang, L. Reyes, M. Tector, J. Tector

    University of Alabama-Birmingham, Birmingham, AL

    *Purpose: Xenotransplantation, the use of genetically-modified pig organs for transplantation, has been limited by antibody-mediated rejection. The generation of a three-antigen knockout pig provided a…
  • 2018 American Transplant Congress

    Feasibility of a National Class II Matching Strategy for Pediatric Kidney Transplant Candidates

    T. Blydt-Hansen,1 W. Klement,2 K. Tinckam,3 J. Gill.1

    1University of British Columbia, Vancouver, Canada; 2Canadian Blood Services, Ottawa, Canada; 3University of Toronto, Toronto, Canada.

    Antibody-mediated rejection (AMR) is a major concern for allograft failure, which could be mitigated by allocation of Class II matched donors. Since children have priority,…
  • 2018 American Transplant Congress

    Dual Inhibition of PI3K and mTORC2 Causes ERK Hyperactivation Induced by HLA-II Antibody in Human Endothelium

    Y-.P. Jin, E. Reed.

    Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA.

    Background: Endothelial cells (EC) line the inner surface of blood vessels and serve as the interface between recipient circulating blood and the donor allograft. Transplant…
  • 2018 American Transplant Congress

    The Complexity of HLA-DQ

    D. Pinelli, A. Tambur.

    Northwestern University, Chicago.

    Historically, HLA-DQ antigens and antibodies (Ab) were difficult to classify due to the lack of serological typing reagents. However, with the advent of molecular typing…
  • 2018 American Transplant Congress

    ABO-Incompatibility Lower Incidence of DSA-Induced Antibody-Mediated Rejection

    D. Lee,1 B. Kim,1 J. KIm,1 I. KIm,1 M. Jeon.1

    1Nephrology, Medicine, Maryknoll General Hospital, Busan, Republic of Korea; 2Laboratory Medicine, Maryknoll General Hospital, Busan, Republic of Korea; 3Surgery, Maryknoll General Hospital, Busan, Republic of Korea; 4Urology, Maryknoll General Hospital, Busan, Republic of Korea; 5Pathology, Maryknoll General Hospital, Busan, Republic of Korea.

    Introduction:Donor-specific anti-HLA antibody (DSA) and Anti-ABO antibody are major barriers for successful kidney transplantation. Limited data are available about the existences of both DSA and…
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