2020 American Transplant Congress
Influence of HLA Compatibility on Cytomegalovirus Infection Post-Kidney Transplantation
*Purpose: Cytomegalovirus (CMV) infection after kidney transplantation is associated with a high morbidity and higher risk of graft loss. A latent Human CMV infection can…2020 American Transplant Congress
Influence of Human Leukocyte Antigen Status and Gender of Positive Crossmatch Patients on Long-Term Survival Outcomes of Antibody Incompatible Renal Transplantation
*Purpose: Human Leukocyte Antigen (HLA) sensitization is a significant obstacle which limits the use of renal transplantation, but it serves as a therapeutic option for…2020 American Transplant Congress
Can HLA-DQ Molecular Mismatch Analysis Be Used to Predict Generation of De Novo Donor-Specific Antibody at an Individual Patient Level?
1Northwestern University, Chicago, IL, 2SUNY Upstate Medical University, Syracuse, NY
*Purpose: De novo donor-specific antibodies (dnDSA), especially to HLA-DQ, are one of the leading causes of late kidney graft failure. Many investigators have attempted to…2019 American Transplant Congress
Upregulation of Endothelial HLA Class II as a Marker of Antibody Mediated Rejection in Heart Allograft Biopsies
Pathology, UTSW Medical Ctr, Dallas, TX
*Purpose: In 2013, the ISHLT (International Society of Heart and Lung Transplant) introduced the working classification for pathological changes associated with antibody-mediated rejection of the…2019 American Transplant Congress
Relationship between HLA-DPB1 Gene Expression in Pre-Implantation Kidney Biopsies, Rs9277534 Polymorphism, and Late Graft Function
*Purpose: A previous gene expression microarray study in pre-implantation biopsies (PIB) from kidneys of adult deceased donors (D) showed association between high class II HLA…2019 American Transplant Congress
Targeted Epitope Mutagenesis as a Strategy to Decrease Xenoantibody Binding
University of Alabama-Birmingham, Birmingham, AL
*Purpose: Xenotransplantation, the use of genetically-modified pig organs for transplantation, has been limited by antibody-mediated rejection. The generation of a three-antigen knockout pig provided a…2018 American Transplant Congress
Feasibility of a National Class II Matching Strategy for Pediatric Kidney Transplant Candidates
Antibody-mediated rejection (AMR) is a major concern for allograft failure, which could be mitigated by allocation of Class II matched donors. Since children have priority,…2018 American Transplant Congress
Dual Inhibition of PI3K and mTORC2 Causes ERK Hyperactivation Induced by HLA-II Antibody in Human Endothelium
Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA.
Background: Endothelial cells (EC) line the inner surface of blood vessels and serve as the interface between recipient circulating blood and the donor allograft. Transplant…2018 American Transplant Congress
The Complexity of HLA-DQ
Northwestern University, Chicago.
Historically, HLA-DQ antigens and antibodies (Ab) were difficult to classify due to the lack of serological typing reagents. However, with the advent of molecular typing…2018 American Transplant Congress
ABO-Incompatibility Lower Incidence of DSA-Induced Antibody-Mediated Rejection
Introduction:Donor-specific anti-HLA antibody (DSA) and Anti-ABO antibody are major barriers for successful kidney transplantation. Limited data are available about the existences of both DSA and…
American Transplant Congress abstracts