2022 American Transplant Congress
Detection of Alloreactive CD8+ T Cell Responses and the Immunopeptidome That Elicits Their Activation
*Purpose: T cell-mediated rejection results in graft dysfunction and contributes to premature failure. Due to the complexity of the TCR:pMHC interaction, prediction of alloreactive T…2022 American Transplant Congress
Ficoll-Based Isolation Alters the Immunogenicity of Islets That Leads to Enhanced Rejection in Allogeneic Hosts
*Purpose: The purification of pancreatic islets has long relied on the time-consuming density gradient separation method. We herein report a filtration method as an efficient,…2021 American Transplant Congress
Marginal Zone B Cells Support Donor-Specific Alloantibody Responses to Heart Allografts
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Production of high affinity isotype-switched donor specific alloantibodies (DSA) after transplantation is associated with germinal center formation by follicular (FO) B cells whereas the…2021 American Transplant Congress
Antibodies to Hla Molecules Lead to Induction and Release of Circulating Exosomes with Lung Self-Antigens
St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Antibodies (Abs) to human leukocyte antigen (HLA) (anti-HLA) can injure allograft by complement-dependent/independent mechanisms. Crosslinking of HLA-class I with Abs associate with integrin β4…2021 American Transplant Congress
Combined Donor Derived Cell Free DNA (AlloSure) and Peripheral Immune Cell Gene Expression (AlloMap) Testing for the Diagnosis of Rejection in Kidney Transplant Recipients with De Novo Donor Specific Antibodies
University of Wisconsin, Madison, WI
*Purpose: Combined donor-derived cell-free DNA (dd-cfDNA, AlloSure) and peripheral immune cell gene expression (AlloMap) may increase the predictive value of de novo DSA (dnDSA) for…2020 American Transplant Congress
Low HLA Class I Epitope Mismatch Associated with Improved Pancreas Graft Survival in Simultaneous Pancreas-Kidney Transplantation
University of Alabama-Birmingham, Birmingham, AL
*Purpose: Antibody-mediated rejection remains the principal cause of allotransplant graft failure. Human leukocyte antigen (HLA) matching between donor and recipients significantly reduces the risk of…2020 American Transplant Congress
Influence of HLA Compatibility on Cytomegalovirus Infection Post-Kidney Transplantation
*Purpose: Cytomegalovirus (CMV) infection after kidney transplantation is associated with a high morbidity and higher risk of graft loss. A latent Human CMV infection can…2020 American Transplant Congress
Inducing Donor MHC Chimerism with Bone Marrow Derived Exosomes in Non-Human Primates
*Purpose: Cardiac allograft tolerance in non-human primates (NHPs) has been achieved by our group via hematopoietic mixed chimerism consisting of an allogeneic bone marrow (BM)…2020 American Transplant Congress
Crosstalk between TLR4 and HLA Class I Mediates P-Selectin Expression and Monocyte Capture to Endothelial Cells
Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA
*Purpose: Transplant recipients developing donor specific HLA antibodies (DSA) are at risk for acute and chronic antibody-mediated rejection (AMR). DSA contribute to the process of…2019 American Transplant Congress
PD-1+CD3+CD4-CD8- (Double Negative T-cells) Are Early Responders during Kidney Ischemia Reperfusion Injury and Regulated by Non-Classical MHC Molecules
Johns Hopkins University and School of Medicine, Baltimore, MD
*Purpose: Unconventional T-cells (e.g. Tregs and γδT-cells) are increasingly recognized for their roles in maintaining homeostasis and protecting non-lymphoid tissues against injury/stress. Double negative (DN)…
American Transplant Congress abstracts