Articles tagged "Lymph node"

2020 American Transplant Congress
Pleural Exosome Mediated Donor Antigen Trafficking Into Mediastinal Lymph Nodes Represents a Novel Pathway of Recipient T Cell Activation in Lung Transplantation
A. Habertheuer¹, A. Japp², C. Ram³, S. Chatterjee⁴, S. Rostami², L. Korutla⁵, T. Ochiya⁶, A. Naji², D. Kreisel⁷, P. Vallabhajosyula⁵
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Surgery, University of Pennsylvania, Philadelphia, PA, ³New York University, New York, NY, ⁴Pathology, University of Pennsylvania, Philadelphia, PA, ⁵Surgery, Yale University, New Haven, CT, ⁶National Cancer Center Japan, Tokyo, Japan, ⁷Surgery, Washington University, St. Louis, MO
*Purpose: Studies in lung transplant models suggest that reestablishment of lymphatic continuum of pulmonary allograft via lymphangiogenesis is required for selective trafficking of donor antigen…
2019 American Transplant Congress
Sphingosine 1-Phosphate Receptor 2 Regulates Migration through Endothelial Cell VCAM and Adherens Junctions
Y. Xiong¹, W. Piao¹, C. Brinkman¹, L. Li¹, J. Kulinski², A. Olivera², A. Cartier³, T. Hla³, K. Hippen⁴, B. Blazar⁴, S. Schwab⁵
¹Surgery, UMB, Baltimore, MD, ²NIH, Bethesda, MD, ³Boston Children's hospital, Boston, MA, ⁴U.Minnesota, Minneapolis, MN, ⁵NYU, NY, NY
*Purpose: Lymphatic endothelial cells (LEC) highly expres S1PR1 and S1PR2. The ligand S1P is produced by LEC and regulates T cell migration. The mechanisms of…
2019 American Transplant Congress
Sphingosine 1-Phosphate Receptors and CCR7 Sequentially Coordinate T Cell Migration
Y. Xiong¹, W. Piao¹, C. Brinkman¹, J. Kulinski², A. Olivera², A. Cartier³, T. Hla⁴, K. Hippen⁵, B. Blazar⁵, S. Schwab⁶, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²NIH, Bethesda, MD, ³Boston Children's hospital, Boston, MA, ⁴Boston Children's hospital, Boston, MD, ⁵U.Minnesota, Minneapolis, MN, ⁶NYU, NY, NY
*Purpose: CCR7 plays critical roles in T cell migration to CCL21 across lymphatic endothelial cells from tissues to lymph nodes (LN). S1PR1 and S1PR4 are…
2019 American Transplant Congress
S1PR1 and S1PR4 Regulate T Cell Migration into Afferent Lymphatics
Y. Xiong¹, W. Piao¹, C. Brinkman¹, L. Li¹, J. Kulinski², A. Olivera², A. Cartier³, T. Hla⁴, K. Hippen⁵, B. Blazar⁶, S. Schwab⁷, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²NIH, Bethesda, MD, ³Boston Children's hospital, Boston, MA, ⁴Boston Children's, Boston, MA, ⁵U.Minnesota, Minneapolis, MN, ⁶U.Minnesota, Minneapolis, MD, ⁷NYU, NY, NY
*Purpose: T cells utilize S1PR1 to traffic from thymus into blood, and lymph nodes (LN) into efferent lymphatics. Whether T cell S1PR1 and S1PR4 regulate…
2018 American Transplant Congress
CD4 T Cells Require Both S1PR1 and S1PR4 for Afferent Lymphatic Migration
Y. Xiong,¹ W. Piao,¹ C. Brinkman,¹ L. Li,¹ J. Kulinski,² A. Olivera,² A. Cartier,³ T. Hla,³ S. Schwab,⁴ K. Hippen,⁵ B. Blazar,⁵ J. Bromberg.¹
¹UMB, MD; ²NIH, MD; ³Boston Children's Hospital, MA; ⁴NYU, NY; ⁵U. Minnesota, MN.
Introduction: Sphingosine 1-phospate (S1P) receptor 1 (S1PR1) drives T cell migration from thymus into blood, and lymph nodes (LN) into efferent lymphatics. Whether S1PR1 and…
2018 American Transplant Congress
Lymphatic Endothelium Requires S1PR2 for T Cell Transendothelial Migration
Y. Xiong,¹ W. Piao,¹ C. Brinkman,¹ L. Li,¹ J. Kulinski,² A. Olivera,² A. Cartier,³ T. Hla,³ S. Schwab,⁴ K. Hippen,⁵ B. Blazar,⁵ J. Bromberg.¹
¹UMB, MD; ²NIH, MD; ³Boston Children's Hospital, MA; ⁴NYU, NY; ⁵U. Minnesota, MN.
Introduction: Sphingosine 1-phosphate (S1P) receptors 1 (S1PR1) and S1PR2 are highly expressed by lymphatic endothelial cells (LEC), while T cells express S1PR1 and S1PR4. S1P…
2018 American Transplant Congress
Lymph Node Reprogramming: Microparticle Delivery of Immune Signals to Induce Tolerance and Prolong Allograft Survival
Y. Xiong,¹ L. Tostanoski,² C. Jewell,² J. Bromberg.¹
¹UMB, MD; ²UMCP, MD.
Introduction: Microparticle (MP) loaded with peptide antigen plus other immune signals and delivered directly into lymph nodes (LN) can result in either pro-inflammatory or anti-inflammatory…
2017 American Transplant Congress
CD4 T Cell Migration Across Lymphatic Endothelium Is Enhanced by Sphingosine 1-Phosphate (S1P) and Differentially Regulated by S1P Receptors (S1PR).
Y. Xiong,¹ C. Brinkman,¹ K. Hippen,² B. Blazar,² J. Bromberg.¹
¹UMB, Baltimore; ²UM, Minneapolis
Introduction: S1PR1 drives T cells to migrate from thymus to blood, and from lymph node (LN) to efferent lymphatics. Whether S1PR1 or other S!PRs regulate…
2017 American Transplant Congress
Favorable Long-Term Prognosis of Hepatitis B Surface Antigen Positive Intrahepatic Cholangiocarcinoma for Both Hepatic Resection and Incidental Liver Transplantation via Inhibiting Cancer-Associated Lymphangiogenesis.
J. Gu, S. Jeong, M. Sha, J. Zhang, Q. Xia.
Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Background: In recent years, a few publications indicated that hepatitis B virus (HBV) infection is associated with the prognosis of patients with ICC after resection.…
2016 American Transplant Congress
T-Bet Regulates nTreg Stability and Suppression in an Islet Allograft Model.
Y. Xiong, S. Ahmad, D. Iwami, C. Brinkman, J. Bromberg.
University of Maryland, Baltimore.
The transcription factor T-bet endows Treg with properties tosuppress Th1 inflammation. However, the mechanisms by which T-bet controls alloimmune responses are not fully understood. We…