ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Lymph node"

  • 2022 American Transplant Congress

    Targeted Delivery of Costimulation Inhibitor to Lymph Nodes Promotes Transplant Tolerance via Fibroblastic Reticular Cells

    J. Zhao1, S. Jung1, X. Li1, H. Zhang1, S. Movahedi1, V. Kasinath1, M. Uehara1, J. Azzi1, P. Sage1, S. Tullius1, J. S. Bromberg2, R. Abdi1

    1Brigham and Women's Hospital, Boston, MA, 2University of Maryland School of Medicine, Baltimore, MD

    *Purpose: The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Fibroblastic reticular cells (FRCs), the prominent cells of the…
  • 2022 American Transplant Congress

    Fibroblastic Reticular Cell Subset Transcriptional Reprogramming Differs in Response to Immunity versus Tolerance

    L. Li1, Y. Song1, M. Shirkey1, A. Kensiski1, W. Piao1, V. Saxena1, S. Gavzy1, B. Ma1, R. Abdi2, J. Bromberg1

    1UMB, Baltimore, MD, 2Harvard University, Boston, MD

    *Purpose: Lymph node (LN) fibroblastic reticular cells (FRCs) are central contributors to the LN niche. We hypothesized that FRC subsets reactive to immunity versus tolerance…
  • 2022 American Transplant Congress

    Deletion of Fibroblastic Reticular Cell Derived Laminin A4 Impairs Lymph Node Vasculature and Conduits

    L. Li1, M. Shirkey1, W. Piao1, A. Kensiski1, V. Saxena1, T. Zhang1, X. Li2, J. Zhao2, S. Gavzy1, R. Abdi2, J. Bromberg1

    1UMB, Baltimore, MD, 2Harvard University, Boston, MA

    *Purpose: Fibroblastic reticular cells (FRCs) support lymph node (LN) structure by producing various functional extracellular matrix (ECM) components. We hypothesized that FRCs and their ECM…
  • 2022 American Transplant Congress

    Immunosuppressants Alter Lymph Node Architecture and Create Distinct Microbiome Footprints

    S. J. Gavzy1, R. Lakhan2, J. Iyyathurai2, V. Saxena2, L. Li2, B. Ma2, E. Mongodin2, J. S. Bromberg2

    1University of Maryland School of Medicine, Baltimore, MD, 2University of Maryland, Baltimore, MD

    *Purpose: There are complex interactions among immunosuppressants, antibiotics, and the gut microbiome on the host immune system. Microbiota can alter lymph node (LN) structure and…
  • 2021 American Transplant Congress

    Laminins Differentially Regulate Tolerogenic T Cell Migration and Homing to Lymph Nodes

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena2, T. Zhang1, J. Iyyathurai2, R. Lakhan1, R. Abdi3, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2CVID, UMB, Baltimore, MD, 3Harvard University, Boston, MA

    *Purpose: Laminin α5 (Lama5) and α4 (Lama4), which are produced by lymph node (LN) stromal cells, influence CD4 T cell migration and stimulation. We hypothesized…
  • 2020 American Transplant Congress

    Costimulation Blockade-Based Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model

    R. Schmitz, Z. W. Fitch, P. M. Schroder, A. Y. Choi, M. Manook, J. Yoon, J. Kwun, S. J. Knechtle

    Department of Surgery, Duke University Medical Center, Durham, NC

    *Purpose: Sensitized transplant recipients represent a challenging population in part due to the presence of donor-specific antibodies (DSA), which increase the risk of antibody-mediated rejection.…
  • 2020 American Transplant Congress

    Characterization of Laminin Alpha 4 Conditional Knockout Mice: Model for Immune Stimulation

    M. W. Shirkey, L. Li, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Paluskievicz, J. Bromberg

    U. Maryland, Baltimore, MD

    *Purpose: Lymph node (LN) stromal laminin α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We created a Lama4 conditional knockout (KO)…
  • 2020 American Transplant Congress

    Pleural Exosome Mediated Donor Antigen Trafficking Into Mediastinal Lymph Nodes Represents a Novel Pathway of Recipient T Cell Activation in Lung Transplantation

    A. Habertheuer1, A. Japp2, C. Ram3, S. Chatterjee4, S. Rostami2, L. Korutla5, T. Ochiya6, A. Naji2, D. Kreisel7, P. Vallabhajosyula5

    1Surgery, University of Pittsburgh, Pittsburgh, PA, 2Surgery, University of Pennsylvania, Philadelphia, PA, 3New York University, New York, NY, 4Pathology, University of Pennsylvania, Philadelphia, PA, 5Surgery, Yale University, New Haven, CT, 6National Cancer Center Japan, Tokyo, Japan, 7Surgery, Washington University, St. Louis, MO

    *Purpose: Studies in lung transplant models suggest that reestablishment of lymphatic continuum of pulmonary allograft via lymphangiogenesis is required for selective trafficking of donor antigen…
  • 2020 American Transplant Congress

    Ex Vivo Generated Regulatory B Cells Can Suppress Donor-Specific CD4 T Cells Proliferation In Vivo

    G. Huai1, K. M. Lee1, Q. Fu1, K. Deng1, N. J. Feeney1, C. Leguern1, N. Tanimine1, C. G. Rickert1, S. Deng2, J. F. Markmann1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Organ Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine, University of Electronic Science and Technology of China, Chengdu, China

    *Purpose: B cells expanded in vitro via TLR9 agonist CpG and activated by LPS, PMA and ionomycin have been previously denoted “TLR-Bregs” by our team.…
  • 2020 American Transplant Congress

    Laminin Alpha5 Regulates T Cell Entry and Distribution in Lymph Nodes in Immunity

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena1, T. Zhang1, C. Paluskievicz1, J. Zhao2, R. Abdi2, J. S. Bromberg1

    1UMB, Baltimore, MD, 2Harvard University, Boston, MA

    *Purpose: Laminin α5 (Lama5) and α4 (Lama4) are lymph node (LN) stromal fibers whose expression ratio influences CD4+ T cell migration and stimulation. We hypothesized…
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