Articles tagged "Liver grafts"

2020 American Transplant Congress
Characterization of a Clinically Scaled Bioengineered Liver Seeded with Primary Hepatocytes and Endothelial Cells
D. S. Davidow¹, J. J. Ross¹, B. D. Anderson¹, A. Stumbras¹, A. A. Katane¹, R. Lindeman¹, B. G. Steiner¹, A. Mendenhall¹, K. Gahlbeck¹, S. Armstrong¹, B. P. Amiot², E. D. Nelson², T. Gilbert¹, S. L. Nyberg²
¹Miromatrix, Eden Prairie, MN, ²Mayo Clinic, Rochester, MN
*Purpose: Advancements in whole organ bioengineering have the potential to offer solutions to a chronically insufficient donor organ supply. We recently demonstrated an ability to…
2020 American Transplant Congress
The Impact of Non-Directed Anonymous Live Liver Donors on the Number of Children on the Waitlist at a Single Pediatric Liver Transplant Center
D. Yoeli¹, M. A. Adams¹, M. E. Wachs¹, S. S. Sundaram², R. A. Choudhury¹, K. D. Conzen¹, J. R. Burton³, E. A. Pomfret¹, W. E. Jackson³
¹Transplant Surgery, University of Colorado, Aurora, CO, ²Pediatric Hepatology, University of Colorado, Aurora, CO, ³Transplant Hepatology, University of Colorado, Aurora, CO
*Purpose: Since the initiation of our living donor (LD) pediatric liver transplant program in November 2016, 10 non-directed anonymous donors have been approved and completed…
2020 American Transplant Congress
Patients in Donor Service Areas with Higher Median MELD at Transplant Have a Lower Probability of Liver Transplant Waitlist Activation
J. Merola¹, S. Noreen², D. Stewart², R. Batra¹, D. Haakinson¹, G. Gan³, Y. Deng³, S. Kulkarni¹
¹Yale School of Medicine, New Haven, CT, ²United Network of Organ Sharing, Richmond, VA, ³Yale Center for Analytical Sciences, Yale University, New Haven, CT
*Purpose: US allocation of hepatic allografts is prioritized based on medical need, however significant geographical disparities exist with median MELD at transplant across donor specific…
2020 American Transplant Congress
Development and Characterization of Decellularized Whole Human Livers for Increasing Donor Pool
A. Acun, R. Oganesyan, B. E. Uygun
Massachusetts General Hospital - Harvard Medical School, Boston, MA
*Purpose: Liver diseases are recognized as the second leading cause of mortality amongst all digestive diseases in the United States. Orthotopic liver transplantation leads to…
2020 American Transplant Congress
Adult Living Donor Liver Transplantation Results in Superior Patient and Graft Survival When Compared to Deceased Donor Liver Transplantation: A Systematic Review and Meta-Analysis
A. Barbetta¹, M. Aljehani², M. KIM¹, C. Tien³, A. Ahearn¹, H. Schilperoort², L. Sher¹, J. Emamaullee¹
¹Surgery, abdominal transplat, University of Southern California, Los Angeles, CA, ²University of Southern California, Los Angeles, CA, ³Surgery, abdominal transplat, Keck Medical School, University of Southern California, Los Angeles, CA
*Purpose: Center-specific or national registry studies have shown that living donor liver transplantation (LDLT) decreases waitlist mortality, reduces waiting time, and may offer superior patient…
2020 American Transplant Congress
Impact of the Baseline Anti-A/B IgG Titer on the Clinical Outcome in ABO-Incompatible Liver Transplantation
J. Lee¹, E. Kim¹, S. Yang¹, D. Kim², M. Ju³, J. Lee¹, M. Kim¹, S. Kim¹, D. Joo¹
¹Department of Transplantation Surgery, Severance Hospital, Seoul, Korea, Republic of, ²Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of, ³Department of Surgery, Gangam Severance Hospital, Seoul, Korea, Republic of
*Purpose: The use of ABO incompatible (ABOi) living donors is an attractive solution for expanding the liver donor pool. We investigated the impact of the…
2020 American Transplant Congress
Humanized Mouse Reveals the Cytoprotective Function of Hepatocyte RXFP1 in Liver Transplant Recipients
H. Kojima¹, S. Kageyama¹, K. Kadono¹, H. Hirao¹, K. J. Dery¹, T. Ito¹, G. Sugahara², Y. Ishida², T. Saito², F. M. Kaldas¹, R. W. Busuttil¹, J. W. Kupiec-Weglinski¹
¹Surgery, The Dumont-UCLA Transplantation Center, Los Angeles, CA, ²Division of Gastrointestinal and Liver Disease, Keck School of Medicine, USC, Los Angeles, CA
*Purpose: RXFP1 (RLX family peptide receptor 1) is a cognate receptor for relaxin (RLX), an insulin-like growth factor, with vasoactive/remodeling properties. We have documented cytoprotective…
2020 American Transplant Congress
Human Live Donor Liver Transplantation is Associated with Pd-l1 Expression on Donor-Exosome-Acquiring Host Dendritic Cells
D. Lema, E. Jankowska-Gan, D. Al-Adra, W. Burlingham
Surgery- Transplantation, University of Wisconsin-Madison, Madison, WI
*Purpose: Liver transplantation (LTx) has been associated with the phenomenon of “cross-dressing” of recipient dendritic cells (DCs) by donor exosome-derived MHC antigens, and acquisition of…
2020 American Transplant Congress
Factors Predicting Outcome after Living Donor Liver Transplantation in the Era of Intra-Operative Flow Measurements and Inflow Modulation
D. Sonbare, D. Jorgensen, A. Humar
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: To identify pre/intra-operative factors which predict adverse outcome after living donor liver transplantation (LDLT).*Methods: All patients who underwent first LDLT at UPMC, Pittsburgh from…
2020 American Transplant Congress
Impact of UNOS Acceptance Sequence Number on Liver Graft Survival
C. Thornley, O. Kezirian, S. Mehta, J. Cashman, J. Brink, T. Chaly Jr, W. Van der Werf
University of Arizona/Banner University Medical Center Phoenix, Phoenix, AZ
*Purpose: Many initially declined liver grafts will go on to be successfully transplanted into other candidates. Limited information exists regarding outcomes of liver grafts that…

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