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American Transplant Congress abstracts

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Articles tagged "Liver grafts"

  • 2022 American Transplant Congress

    Cold Stress-Induced Ferroptosis in Liver Sinusoidal Endothelial Cells Deteriorates Liver Transplant Outcomes

    H. Kojima, H. Hirao, K. Kadono, T. Ito, K. J. Dery, F. Kaldas, J. Kupiec-Weglinski

    UCLA Medical Center, Los Angeles, CA

    *Purpose: While hepatocytes are affected by ischemia-reperfusion injury (IRI) especially under normothermic stress, liver sinusoidal endothelial cells (LSECs) are particularly vulnerable to cold storage-induced IR-insult.…
  • 2022 American Transplant Congress

    Comparative Analysis of Liver Organ Offers Pre- and Post- Acuity Circle Policy Change in the US

    V. Reddy1, R. Ruiz2, H. Fernandez3, J. Bayer3, E. Martinez3, A. Gupta3, G. McKenna4, N. Onaca3, S. Lee3, T. Ma3, G. Testa3, A. Wall3

    1Baylor Scott and White Research Institute, Allen, TX, 2Baylor University Medical Center, Fort Worth, TX, 3Baylor University Medical Center, Dallas, TX, 4Baylor Simmons Transplant Inst, Dallas, TX

    *Purpose: With the intended goal of reducing geographic inequities, the United Network for Organ Sharing (UNOS) and Organ Procurement and Transplantation Network (OPTN) transitioned to…
  • 2022 American Transplant Congress

    Final Report of the Use of α-Lipoic Acid in Liver Transplantation to Prevent Ischemia Reperfusion Injury

    P. C. Casciato1, N. Ambrosi2, F. Caro2, L. Oliveira1, F. Zalazar1, A. Garmendia1, M. Bonifacio1, M. Padilla1, J. Paladini1, J. Di Menno1, J. Pekjol1, E. de Santibañes1, M. de Santibañes1, G. Adrian1, C. Incardona1, E. Chuluyan2

    1Hospital Italiano, Buenos Aires, Argentina, 2CEFYBO, Buenos Aires, Argentina

    *Purpose: The ischemia and reperfusion injury contributs to grafts deterioration and adverse post-transplant outcomes. The aim of the present study was to evaluate the safety…
  • 2022 American Transplant Congress

    Real-Time Application of Deep Learning in Diagnosis of Graft Fibrosis After Liver Transplantation Using Longitudinal Data

    A. Azhie1, D. Sharma2, P. Sheth1, W. Xu3, M. Bhat1

    1Ajmera Transplant Program, University Health Network, Toronto, ON, Canada, 2Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, 3Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada

    *Purpose: Graft fibrosis develops insidiously in liver transplant recipients and is associated with worse survival. Early detection of fibrosis is essential to avoid further progression…
  • 2022 American Transplant Congress

    Development of a Portable Device to Quantify Hepatic Steatosis in Donated Livers Using an AI Algorithm

    S. Klinkachorn1, C. J. Tsoi-A-Sue2, R. R. Narayan2, M. L. Melcher2

    1Computer Science, Stanford, Stanford, CA, 2Surgery, Stanford, Stanford, CA

    *Purpose: An accurate estimation of liver fat content is necessary to predict how a donor liver will function after transplantation. This can be challenging at…
  • 2022 American Transplant Congress

    Gene Profiling to Distinguish Mechanisms of Liver Allograft Rejection and Acceptance in Cynomolgus Monkey

    H. Sakai1, E. Berglund1, S. Chaudhry1, Y. Kato1, E. Duggan1, J. Weiner1, P. Alonso-Guallart1, N. Llore1, K. Brustle1, J. Stern1, B. Piegari1, D. Ekanayake-Alper1, M. Martinez2, G. Pierre1, M. Danton1, S. Kofman1, D. Ordanes1, D. Hajosi1, J. Lefkowitch3, A. Iuga1, T. Kato4, A. Griesemer1

    1Columbia Center for Translational Immunology, Columbia University, New York, NY, 2Department of Pediatrics, Columbia University, New York, NY, 3Departments of Pathology and Cell Biology, Columbia University, New York, NY, 4Department of Surgery, Columbia University, New York, NY

    *Purpose: Liver is an immune regulatory organ. Spontaneous resolutions from rejection have been seen in our orthotopic cynomolgus monkey liver transplant models for tolerance induction…
  • 2022 American Transplant Congress

    End-to-Side Splenic to Hepatic Artery Reconstruction in Liver Transplant: A Case Series

    N. Baker, L. Aviles-Ovalle, T. Baker, J. Campsen, R. Kim, G. Rofaiel

    Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT

    *Purpose: Optimal hepatic artery (HA) blood flow post-liver transplantation (LT) is necessary for long-term allograft success. HA thrombosis (HAT) contributes to significant morbidity and mortality…
  • 2022 American Transplant Congress

    Utilizing Microsurgeon Expertise in the Salvage of Hepatic Artery Dissection

    R. Sitta1, N. Ascher2, J. Roberts2, M. Piper3

    1General Surgery, UCSF, San Francisco, CA, 2Abdominal Transplant Surgery, UCSF, San Francisco, CA, 3Plastic and Reconstructive Surgery, UCSF, San Francisco, CA

    *Purpose: Living donor hepatic artery intimal dissection is a rare but devastating complication often resulting in inability to utilize the graft. We detail the salvage…
  • 2022 American Transplant Congress

    Pretransplant microRNAs in Liver Perfusate Associate with Early Allograft Dysfunction

    E. Bardhi, E. Williams, J. McDaniels, T. Rousselle, V. Mas, D. Maluf

    University of Maryland School of Medicine, Baltimore, MD

    *Purpose: Early allograft dysfunction (EAD) in liver transplantation (LT) is associated with poor long-term graft and patient survival. Prior to LT, while organs are stored…
  • 2021 American Transplant Congress

    Platelets Stimulate Liver Regeneration After Partial Liver Transplantation

    K. Takahashi, C. Liang, K. Furuya, T. Oda

    GI and HBP Surgery, University of Tsukuba, Tsukuba, Japan

    *Purpose: Living donor liver transplant (LDLT) can sometimes be associated with impaired regeneration and severe ischemia/reperfusion (I/R) injury in the liver graft, resulting in small-for-size…
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