ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Liver grafts"

  • 2017 American Transplant Congress

    Myeloid HO-1 Orchestrates Liver Graft Function via SIRT1/p53 Signaling: From Mouse-to-Human.

    K. Nakamura,1 M. Zhang,2 B. Ke,1 S. Kageyama,1 N. Datta,1 A. Zarrinpar,1 R. Busuttil,1 J. Araujo,2 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplant, UCLA, Los Angeles, CA; 2Department of Medicine, UCLA, Los Angeles, CA; 3Department of Pathology, UCLA, Los Angeles, CA

    Background/Aim: Although the efficacy of heme oxygenase-1 (HO-1) to combat liver ischemia-reperfusion injury (IRI) in animal models is well-established, cell-specific HO-1 function and mechanisms of…
  • 2017 American Transplant Congress

    Decellularized Rat Liver Scaffolds Support Survival and Metabolic Function of Multilineage Allogenic Cells.

    W. Hassanein, A. Werdesheim, A. Cimeno, B. Buckingham, A. Khalifeh, M. Uluer, J. Harrison, D. Parsell, C. Drachenberg, R. Barth, J. LaMattina.

    University of Maryland School of Medcine, Baltimore, MD

    Background:Organ bioengineering has the potential to completely eliminate the donor organ shortage. Here, we examine the feasibility of a decellularized liver construct to support the…
  • 2017 American Transplant Congress

    Clearance of Transaminases During Normothermic Ex Vivo Liver Perfusion.

    M. Bral,1 N. Aboelnazar,2 B. Gala-Lopez,2 S. Hatami,2 D. Freed,1 A. Shapiro.1

    1Department of Transplant Surgery, University of Alberta, Edmonton, AB, Canada; 2Department of Experimental Surgery, University of Alberta, Edmonton, AB, Canada

    One of the most promising applications of normothermic ex vivo liver perfusion is the possibility of real-time graft viability assessment. Many liver biomarkers are considered…
  • 2017 American Transplant Congress

    α-Lipoc Acid Improve the Short Term Outcomes in Human Liver Transplantation.

    P. Casciato,1 N. Ambrosi,2 C. Fiorella,2 M. Vasquez,1 A. Gadano,1 M. de Santibañes,1 E. de Santibañes,1 M. Zandomeni,1 M. Chahdi,1 J. Laquinandi,1 P. Santofimia Castaño,3 J. Iovanna,3 E. Chuluyan,2 C. Incardona.4

    1Liver Transplantation Unit, Hospital Italiano, Buenos Aires, Argentina; 2CEFYBO, UBA-CONICET, Facultad de Medicina, Buenos Aires, Argentina; 3INSERM, Center of Research in Cancerology of Marseille (CRCM), Marseille, France; 4Fundación GADOR, GADOR, Buenos Aires, Argentina

    In liver transplantation (LT) the postreperfusion syndrome (PRS) is a serious intraoperative complication. The effect of α-lipoic acid (ALA) has not been evaluated. A double…
  • 2017 American Transplant Congress

    The Delivery of Stem Cell Therapy to Extended Criteria Donor Human Livers Using Normothermic Machine Perfusion.

    R. Laing,1 S. Stubblefield,3 B. Ricky,1 S. Barnaby,2 M. Alfaifi,1 A. Ting,3 D. Mirza,2 P. Newsome,1 H. Mergental,2 S. Afford.1

    1Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom; 2Liver Unit, University Hospital Birmingham, Birmingham, United Kingdom; 3Athersys Inc., Cleveland, OH

    Normothermic machine perfusion of the liver (NMP-L) has been used for organ preservation and viability testing of donor livers. Although previously proposed, delivery of cellular…
  • 2017 American Transplant Congress

    Lactate Level Immediate Post-Liver Transplantation Is a Predictor of Early Allograft Dysfunction.

    K. Takahashi,1,2 S. Nagai,1 M. Safwan,1 K. Putchakayala,1 K. Collins,1 M. Rizzari,1 A. Yoshida,1 M. Abouljoud,1 S.-M. Jafri.3

    1Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; 2Surgery, University of Tsukuba, Tsukuba, Ibaraki, Japan; 3Gastroenterology, Henry Ford Hospital, Detroit, MI

    Background; Early allograft dysfunction (EAD) after liver transplantation (LT) is defined as a peak values of aminotransferase >2000 IU/mL during the first week or an…
  • 2017 American Transplant Congress

    Third Liver Transplantation, Outcomes, and the Impact of Previous Graft Survival.

    M. Barry,1 M. Gupta,2 D. Goldberg,3 M. Levine,2 D. Simpson,2 K. Olthoff,2 A. Shaked,2 P. Abt.2

    1School of Medicine, University of Pennsylvania, Philadelphia, PA; 2Surgery, Division of Transplantation, University of Pennsylvania, Philadelphia, PA; 3Medicine, Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA

    Introduction: Retransplantation with a third liver allograft is controversial with significant technical and medical challenges. National outcomes have not been described. We hypothesize that prior…
  • 2017 American Transplant Congress

    Patency of Autologous Portal Vein “Y“ Graft in Anterior Sector Outflow Reconstruction in Adult Living Donor Right Lobe Grafts.

    S. Kapoor, B. Nath, V. Varma, S. Sable, A. Chauhan, V. Kumaran.

    Liver Transplantation & HPB Surgery, Kokilaben Dhirubhai Ambani Hospital & Medical Research Institute, Mumbai, Maharashtra, India

    Anetrior sector outflow reconstruction is followed by most centers performing right lobe liver transplantation. Recanalised umbilical vein, cryopreserved cadaveric veins/ arteries, PTFE and Recipient's portal…
  • 2017 American Transplant Congress

    The 'W' Technique: A Safe and Reproducible Technique for Hepatic Arterial Reconstruction in Living Donor Liver Transplantation.

    V. Kumaran, V. Varma, S. Kapoor, B. Nath, A. Chauhan, S. Sable, K. Yadav, S. Kumar, S. Sharma.

    Liver Transplant and HPB Surgery, Kokilaben Dhirubhai Ambani Hospital, Mumbai, India

    BackgroundReconstruction of the hepatic artery is technically challenging in living donor liver transplantation (LDLT). We describe outcomes of a safe and easily teachable technique.MethodsA prospectively…
  • 2017 American Transplant Congress

    Readmission and Reoperation After Living Donor Hepatectomy.

    S. Kapoor, B. Nath, V. Varma, S. Sable, A. Chauhan, V. Kumaran.

    Liver Transplantation & HPB Surgery, Kokilaben Dhirubhai Ambani Hospital & Medical Research Institute, Mumbai, India

    Background: Living donor liver transplantation remains the predominant option for patients with acute or chronic liver failure in many regions with poor cadaveric donation rates.…
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