Articles tagged "Liver grafts"

2017 American Transplant Congress
Preliminary Results of Clinical Normothermic Ex Vivo Liver Perfusion in a North American Setting.
M. Bral,¹ B. Gala-Lopez,¹ D. Bigam,¹ N. Kneteman,¹ A. Malcolm,¹ S. Livingstone,¹ A. Andres,¹ J. Emamaullee,¹ L. West,¹ P. Friend,² A. Shapiro.¹
¹Department of Surgery, University of Alberta, Edmonton, AB, Canada; ²Department of Surgery, Nuffield Department of Surgical Sciences, Oxford, United Kingdom; ³Oxford Institute of Biomedical Engineering, Oxford, United Kingdom; ⁴OrganOx, Oxford, United Kingdom
Outcomes of a first clinical normothermic machine perfusion (NMP) UK liver trial demonstrated feasibility and clear safety, with improved liver function when compared to standard…
2017 American Transplant Congress
A Surge in Liver Donors After Years of Decline, Is This the Tip of the Iceberg?
A. Rana,¹ M. Goss,¹ J. Rees,² M. Kueht,¹ J. Vierling,¹ A. Mindikoglu,¹ K. Halazun,³ N. Sussman,¹ B. Kaplan,⁴ P. Wood,⁵ N. Galvan,¹ R. Cotton,¹ C. O'Mahony,¹ J. Goss.¹
¹Abdominal Transplantation, Baylor College of Medicine, Houston; ²Southwest Transplant Alliance Organ Procurement Organization, Dallas; ³Surgery, Weill Cornell Medical Center, New York; ⁴Nephrology, Mayo Clinic, Phoenix; ⁵LifeGift Organ Procurement Organization, Houston
The number of liver donors has steadily declined since 2006, despite numerous efforts to increase donation. Then in 2013 to the current projected numbers for…
2017 American Transplant Congress
Impact of a B-Cell Targeting Agent on Antibody Mediated Rejection and Graft' Survival in Liver Transplantation with Preformed DSAs.
A. Del Bello,¹ V. Dubois,² J. Dumortier,³ N. Congy-Jolivet,⁴ N. Kamar.¹
¹Nephrology and Organ Transplant Department, CHU Toulouse, Toulouse, France; ²Department of Immunology, CHU Lyon, Lyon, France; ³Gastroenterology and Liver Transplant Department, CHU Lyon, Lyon, France; ⁴Department of Immunology, CHU Toulouse, Toulouse, France
Introduction The negative impact of preformed anti-HLA donor specific antibodies (DSAs) in liver transplantation is clearly established. However, the potential interest of a B-cell depleting…
2017 American Transplant Congress
Outcomes of Moderately to Severely Steatotic Grafts in Liver Transplantation: A Meta-Analysis.
K. Bonner,¹ C. Thongprayoon,² W. Cheungpasitporn,¹ M. Leise.¹
¹Mayo Clinic, Rochester; ²Bassett Medical Center, Cooperstown
Background/Objectives:There is a worldwide need to expand the pool of available liver grafts. Livers with >50% steatosis are discarded for orthotopic liver transplantation (OLT) by…
2017 American Transplant Congress
Myeloid HO-1 Orchestrates Liver Graft Function via SIRT1/p53 Signaling: From Mouse-to-Human.
K. Nakamura,¹ M. Zhang,² B. Ke,¹ S. Kageyama,¹ N. Datta,¹ A. Zarrinpar,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²Department of Medicine, UCLA, Los Angeles, CA; ³Department of Pathology, UCLA, Los Angeles, CA
Background/Aim: Although the efficacy of heme oxygenase-1 (HO-1) to combat liver ischemia-reperfusion injury (IRI) in animal models is well-established, cell-specific HO-1 function and mechanisms of…
2017 American Transplant Congress
Decellularized Rat Liver Scaffolds Support Survival and Metabolic Function of Multilineage Allogenic Cells.
W. Hassanein, A. Werdesheim, A. Cimeno, B. Buckingham, A. Khalifeh, M. Uluer, J. Harrison, D. Parsell, C. Drachenberg, R. Barth, J. LaMattina.
University of Maryland School of Medcine, Baltimore, MD
Background:Organ bioengineering has the potential to completely eliminate the donor organ shortage. Here, we examine the feasibility of a decellularized liver construct to support the…
2017 American Transplant Congress
Clearance of Transaminases During Normothermic Ex Vivo Liver Perfusion.
M. Bral,¹ N. Aboelnazar,² B. Gala-Lopez,² S. Hatami,² D. Freed,¹ A. Shapiro.¹
¹Department of Transplant Surgery, University of Alberta, Edmonton, AB, Canada; ²Department of Experimental Surgery, University of Alberta, Edmonton, AB, Canada
One of the most promising applications of normothermic ex vivo liver perfusion is the possibility of real-time graft viability assessment. Many liver biomarkers are considered…
2017 American Transplant Congress
α-Lipoc Acid Improve the Short Term Outcomes in Human Liver Transplantation.
P. Casciato,¹ N. Ambrosi,² C. Fiorella,² M. Vasquez,¹ A. Gadano,¹ M. de Santibañes,¹ E. de Santibañes,¹ M. Zandomeni,¹ M. Chahdi,¹ J. Laquinandi,¹ P. Santofimia Castaño,³ J. Iovanna,³ E. Chuluyan,² C. Incardona.⁴
¹Liver Transplantation Unit, Hospital Italiano, Buenos Aires, Argentina; ²CEFYBO, UBA-CONICET, Facultad de Medicina, Buenos Aires, Argentina; ³INSERM, Center of Research in Cancerology of Marseille (CRCM), Marseille, France; ⁴Fundación GADOR, GADOR, Buenos Aires, Argentina
In liver transplantation (LT) the postreperfusion syndrome (PRS) is a serious intraoperative complication. The effect of α-lipoic acid (ALA) has not been evaluated. A double…
2017 American Transplant Congress
The Delivery of Stem Cell Therapy to Extended Criteria Donor Human Livers Using Normothermic Machine Perfusion.
R. Laing,¹ S. Stubblefield,³ B. Ricky,¹ S. Barnaby,² M. Alfaifi,¹ A. Ting,³ D. Mirza,² P. Newsome,¹ H. Mergental,² S. Afford.¹
¹Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom; ²Liver Unit, University Hospital Birmingham, Birmingham, United Kingdom; ³Athersys Inc., Cleveland, OH
Normothermic machine perfusion of the liver (NMP-L) has been used for organ preservation and viability testing of donor livers. Although previously proposed, delivery of cellular…
2017 American Transplant Congress
Lactate Level Immediate Post-Liver Transplantation Is a Predictor of Early Allograft Dysfunction.
K. Takahashi,^1,2 S. Nagai,¹ M. Safwan,¹ K. Putchakayala,¹ K. Collins,¹ M. Rizzari,¹ A. Yoshida,¹ M. Abouljoud,¹ S.-M. Jafri.³
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ²Surgery, University of Tsukuba, Tsukuba, Ibaraki, Japan; ³Gastroenterology, Henry Ford Hospital, Detroit, MI
Background; Early allograft dysfunction (EAD) after liver transplantation (LT) is defined as a peak values of aminotransferase >2000 IU/mL during the first week or an…