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Articles tagged "Liver grafts"

  • 2018 American Transplant Congress

    Regional Variation in the Outcomes of MELD-Na Based Liver Allocation

    L. Chau,1 D. Moonka,2 K. Collins,1 M. Rizzari,1 A. Yoshida,1 M. Abouljoud,1 S. Nagai.1

    1Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; 2Gastroenterology, Henry Ford Hospital, Detroit, MI.

    Introduction: While there is known geographic discrepancy in waitlist and transplant outcomes in the MELD era, there is a paucity in understanding of these variations…
  • 2018 American Transplant Congress

    Impact of Total Graft Steatotic Mass in Liver Transplant Outcomes

    L. De Gregorio,1 E. Bugeaud,1 G. Galliano,2 H. Bohorquez,1 D. Bruce,1 I. Carmody,1 A. Cohen,1 J. Seal,1 D. Sonnier,1 A. Mathur,1 G. Loss.1

    1Abdominal Transplant Surgery, Ochsner Clinic Foundation, New Orleans, LA; 2Pathology, Ochsner Clinic Foundation, New Orleans, LA.

    INTRODUCTIONGraft steatosis is a risk factor for early allograft dysfunction (EAD) and is thought to portend inferior transplant outcomes. The impact of total steatosis, combining…
  • 2017 American Transplant Congress

    Preliminary Results of Clinical Normothermic Ex Vivo Liver Perfusion in a North American Setting.

    M. Bral,1 B. Gala-Lopez,1 D. Bigam,1 N. Kneteman,1 A. Malcolm,1 S. Livingstone,1 A. Andres,1 J. Emamaullee,1 L. West,1 P. Friend,2 A. Shapiro.1

    1Department of Surgery, University of Alberta, Edmonton, AB, Canada; 2Department of Surgery, Nuffield Department of Surgical Sciences, Oxford, United Kingdom; 3Oxford Institute of Biomedical Engineering, Oxford, United Kingdom; 4OrganOx, Oxford, United Kingdom

    Outcomes of a first clinical normothermic machine perfusion (NMP) UK liver trial demonstrated feasibility and clear safety, with improved liver function when compared to standard…
  • 2017 American Transplant Congress

    A Surge in Liver Donors After Years of Decline, Is This the Tip of the Iceberg?

    A. Rana,1 M. Goss,1 J. Rees,2 M. Kueht,1 J. Vierling,1 A. Mindikoglu,1 K. Halazun,3 N. Sussman,1 B. Kaplan,4 P. Wood,5 N. Galvan,1 R. Cotton,1 C. O'Mahony,1 J. Goss.1

    1Abdominal Transplantation, Baylor College of Medicine, Houston; 2Southwest Transplant Alliance Organ Procurement Organization, Dallas; 3Surgery, Weill Cornell Medical Center, New York; 4Nephrology, Mayo Clinic, Phoenix; 5LifeGift Organ Procurement Organization, Houston

    The number of liver donors has steadily declined since 2006, despite numerous efforts to increase donation. Then in 2013 to the current projected numbers for…
  • 2017 American Transplant Congress

    Impact of a B-Cell Targeting Agent on Antibody Mediated Rejection and Graft' Survival in Liver Transplantation with Preformed DSAs.

    A. Del Bello,1 V. Dubois,2 J. Dumortier,3 N. Congy-Jolivet,4 N. Kamar.1

    1Nephrology and Organ Transplant Department, CHU Toulouse, Toulouse, France; 2Department of Immunology, CHU Lyon, Lyon, France; 3Gastroenterology and Liver Transplant Department, CHU Lyon, Lyon, France; 4Department of Immunology, CHU Toulouse, Toulouse, France

    Introduction The negative impact of preformed anti-HLA donor specific antibodies (DSAs) in liver transplantation is clearly established. However, the potential interest of a B-cell depleting…
  • 2017 American Transplant Congress

    Outcomes of Moderately to Severely Steatotic Grafts in Liver Transplantation: A Meta-Analysis.

    K. Bonner,1 C. Thongprayoon,2 W. Cheungpasitporn,1 M. Leise.1

    1Mayo Clinic, Rochester; 2Bassett Medical Center, Cooperstown

    Background/Objectives:There is a worldwide need to expand the pool of available liver grafts. Livers with >50% steatosis are discarded for orthotopic liver transplantation (OLT) by…
  • 2017 American Transplant Congress

    Myeloid HO-1 Orchestrates Liver Graft Function via SIRT1/p53 Signaling: From Mouse-to-Human.

    K. Nakamura,1 M. Zhang,2 B. Ke,1 S. Kageyama,1 N. Datta,1 A. Zarrinpar,1 R. Busuttil,1 J. Araujo,2 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplant, UCLA, Los Angeles, CA; 2Department of Medicine, UCLA, Los Angeles, CA; 3Department of Pathology, UCLA, Los Angeles, CA

    Background/Aim: Although the efficacy of heme oxygenase-1 (HO-1) to combat liver ischemia-reperfusion injury (IRI) in animal models is well-established, cell-specific HO-1 function and mechanisms of…
  • 2017 American Transplant Congress

    Decellularized Rat Liver Scaffolds Support Survival and Metabolic Function of Multilineage Allogenic Cells.

    W. Hassanein, A. Werdesheim, A. Cimeno, B. Buckingham, A. Khalifeh, M. Uluer, J. Harrison, D. Parsell, C. Drachenberg, R. Barth, J. LaMattina.

    University of Maryland School of Medcine, Baltimore, MD

    Background:Organ bioengineering has the potential to completely eliminate the donor organ shortage. Here, we examine the feasibility of a decellularized liver construct to support the…
  • 2017 American Transplant Congress

    Clearance of Transaminases During Normothermic Ex Vivo Liver Perfusion.

    M. Bral,1 N. Aboelnazar,2 B. Gala-Lopez,2 S. Hatami,2 D. Freed,1 A. Shapiro.1

    1Department of Transplant Surgery, University of Alberta, Edmonton, AB, Canada; 2Department of Experimental Surgery, University of Alberta, Edmonton, AB, Canada

    One of the most promising applications of normothermic ex vivo liver perfusion is the possibility of real-time graft viability assessment. Many liver biomarkers are considered…
  • 2017 American Transplant Congress

    α-Lipoc Acid Improve the Short Term Outcomes in Human Liver Transplantation.

    P. Casciato,1 N. Ambrosi,2 C. Fiorella,2 M. Vasquez,1 A. Gadano,1 M. de Santibañes,1 E. de Santibañes,1 M. Zandomeni,1 M. Chahdi,1 J. Laquinandi,1 P. Santofimia Castaño,3 J. Iovanna,3 E. Chuluyan,2 C. Incardona.4

    1Liver Transplantation Unit, Hospital Italiano, Buenos Aires, Argentina; 2CEFYBO, UBA-CONICET, Facultad de Medicina, Buenos Aires, Argentina; 3INSERM, Center of Research in Cancerology of Marseille (CRCM), Marseille, France; 4Fundación GADOR, GADOR, Buenos Aires, Argentina

    In liver transplantation (LT) the postreperfusion syndrome (PRS) is a serious intraoperative complication. The effect of α-lipoic acid (ALA) has not been evaluated. A double…
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