Articles tagged "Liver failure"

2019 American Transplant Congress
CHOP Deficiency Attenuated Acute Liver Injury by Promoting Macrophage M2 Polarization via ATG5-Mediated Autophagy Activation
H. Zhou, R. Liu, Q. Wang, C. Shi, F. Cheng, X. Wang, L. Lu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Critical roles of CCAAT-Enhancer-Binding Protein Homologous Protein (CHOP) have been found in mediating acute liver injury. The aim of this study is to determine…
2019 American Transplant Congress
Case Series: Anti-Thymocyte Globulin as a Treatment for Steroid-Refractory Severe Acute Hepatitis in Children
A. L. Peters, A. Miethke, K. Campbell
Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: Pediatric severe acute hepatitis (SAH), when not attributed to acetaminophen toxicity, is commonly hypothesized to be caused by a non-typeable viral infection and/or immune…
2018 American Transplant Congress
Clinical Application of Mesenchymal Stromal Cells with a Simplified Protocol for ABO Incompatible Liver Transplantation in Severe Hepatic Failure Patients
Y. Zhang,^1,2 J. Zheng,^1,2 J. Cai,^1,2 J. Zhang,^1,2 K. Zeng,^1,2 J. Yao,^1,2 Y. Yang.^1,2
¹Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Guangzhou, Guangdong, China; ²Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, .
Objective The purpose of this study was to test the safety and efficacy of mesenchymal stromal cells (MSCs) treatment with a simplified protocol for ABO…
2018 American Transplant Congress
Development and Validation of FLF-Transplant Score to Predict Mortality of Status 1A Candidates
Z. Guo, B. Chen, Q. Zhao, E. Xin, Z. Zhang, L. Wang, X. He, G. Chen.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Orthotopic liver transplantation (OLT) is the definitive treatment for patients with fulminant liver failure (Status 1A). We aimed to develop a prognostic model for prediction…
2018 American Transplant Congress
Impact of Donation after Cardiac Death Allografts on Outcome Following Liver Transplantation for Fulminant Hepatic Failure: An Analysis of the UNOS Database
S. Kumar,¹ S. Lin,² J. Schold.²
¹Digestive Disease Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates; ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.
Scarcity of donor organs in liver transplantation (LT) has necessitated consideration of extended criteria donors (ECDs), including donation after cardiac death (DCD) donors. The narrow…
2018 American Transplant Congress
Advanced Liver Care and Salvage Transplantation Improves Outcomes for Patients with Cirrhosis Requiring Abdominal General Surgical Procedures
D. Milgrom,¹ N. Valsangkar,¹ J. Kays,¹ T. Liang,¹ J. Butler,¹ C. Kubal,¹ M. Maluccio,¹ A. Tector,² L. Koniaris.¹
¹Department of Surgery, Indiana University School of Medicine, Indianapolis, IN; ²Department of Transplant Surgery, University of Alabama School of Medicine, Birmingham, AB.
Introduction: Historically, abdominal general surgical procedures on cirrhotic patients carry up to an 80% mortality rate. We hypothesized outcomes of cirrhotic patients requiring abdominal surgical…
2018 American Transplant Congress
Impact of Early Corticosteroid Treatment in Patients with Indeterminate Acute Severe Hepatitis
E. Mohr,¹ R. Sucher,² T. Müller,³ T. Kaiser,⁴ T. Berg.¹
¹Hepatology, University Clinic Leipzig, Leipzig, Germany; ²Transplant Surgery, University Clinic Leipzig, Leipzig, Germany; ³Hepatology, Charite, Berliin, Germany; ⁴Laboratory Diagnostics, University Clinic Leipzig, Leipzig, Germany.
Background and Aims: Discrimination of acute severe autoimmune hepatitis AIH and drug induced liver injury in patients with indeterminate acute severe Hepatitis is challenging. Early…
2018 American Transplant Congress
Portal Vein Flow as an Indicator of Liver Transplantation for Acute Liver Failure
C-.H. Cheng,¹ C. Lee,² Y-.C. Wang,¹ T-.H. Wu,¹ C-.F. Lee,¹ T-.J. Wu,¹ H. Chou,¹ K-.M. Chan,¹ W-.C. Lee.¹
¹Division of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan, Taiwan; ²Department of Hepatology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan, Taiwan.
Background: Liver transplantation is the most effective treatment for acute liver failure. Timing of liver transplantation is important to rescue the dying patients. This study…
2018 American Transplant Congress
Impact of Providing Care Locally Compared to at a Transplant Center for Pre-And Posttransplant Liver Patients
R. Shahbazov,¹ K. Knapp,² S. Tsutsui,² A. Nickkholgh,¹ P. Northup,³ J. Oberholzer,¹ D. Maluf,¹ M. Shiffman,⁴ S. Pelletier.¹
¹Surgery, University of Virginia Healthsystem, Charlottesville, VA; ²University of Virginia School of Medicine, University of Virginia Healthsystem, Charlottesville, VA; ³Gastroenterology, University of Virginia Healthsystem, Charlottesville, VA; ⁴Secours Liver Institute of Richmond, Secours Liver Institute of Richmond, Richmond, VA.
There is a potential to improve patient satisfaction as well as access to liver transplantation (LT). AIM: This study evaluated outcomes of LT recipients whose…
2018 American Transplant Congress
Recipient ABO Blood-Type is Associated with Their Survival after Adult-to-Adult Living-Donor Liver Transplantation: Blood-Type O is Disadvantage?
T. Goto,¹ K. Hata,¹ M. Nagao,² J. Kusakabe,¹ Y. Okamura,¹ T. Tajima,¹ I. Tamaki,¹ Y. Nigmet,¹ T. Tajima,¹ J. Yoshikawa,¹ H. Tanaka,¹ S. Ichiyama,² S. Uemoto.¹
¹Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto City, Japan; ²Department of Infection Control and Prevention, Kyoto University Hospital, Kyoto City, Japan.
PURPOSE: Accumulating evidence has suggested that ABO blood-type is associated with the prevalence and severity of infectious diseases, cancers, and cardiovascular diseases, however, its impact…