Articles tagged "Liver cirrhosis"

2020 American Transplant Congress
Identification of Molecular Markers for Liver Cirrhosis (NASH) by Single-Nucleus RNA Sequencing
C. Kuscu¹, A. Mouhammed², C. Kuscu³, A. R. Wolen³, J. D. Eason³, D. Maluf³, V. Mas³
¹Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN, ²Bioinformatics, University of Tennessee Health Science Center, Memphis, TN, ³Department of Surgery, University of Tennessee Health Science Center, Memphis, TN
*Purpose: Non-alcoholic fatty liver disease (NAFLD) is a progressive disease and it constitutes a significant portion of the chronic liver diseases that affected more than…
2020 American Transplant Congress
Child-Turcotte-Pugh Class at Transplantation Predicts Mortality after Heart Transplantation Following Left Ventricular Assist Device Placement
E. Leven¹, A. T. Kurdi², S. Pinney¹, T. Schiano¹, J. Crismale¹
¹Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, ²Gastroenterology, Mayo Clinic, Rochester, MN
*Purpose: The primary aim of this study is to assess whether Child-Turcotte-Pugh (CTP) class is associated with mortality in end-stage heart disease patients undergoing left…
2020 American Transplant Congress
Evaluation of Pre-Transplant T Cell Exhaustion as a Mechanism for Immune Dysfunction and Recipient Risk of Death Following Liver Transplant
K. E. Lunsford¹, N. Aware², K. Cleveland³, D. T. Nguyen⁴, E. A. Graviss⁴, L. J. Minze³, T. N. Eagar⁴, X. C. Li³, R. M. Ghobrial³
¹Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ, ²Department of Surgery, Houston Methodist Hosptial, Houston, TX, ³Department of Surgery, Houston Methodist Hospital, Houston, TX, ⁴Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX
*Purpose: Cirrhosis-related immune dysfunction likely contributes to early mortality following liver transplant (LT) resulting from infections. We previously identified a pre-transplant biomarker panel for immune…
2020 American Transplant Congress
Acute on Chronic Liver Failure (ACLF) Patients Have a Dynamic and Progressive Clinical Course Until Receiving a Liver Transplant: A 5-Year Study at the National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico
E. Cervantes-Alvarez¹, M. J. Lizardo-Thiebaud¹, E. Alatorre-Arenas¹, O. Mendez-Guerrero¹, S. Yarza-Regalado¹, A. Torre¹, M. Vilatobá², D. Kershenobich¹, C. A. Huang³, N. Navarro-Alvarez¹
¹Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ³Surgery, University of Colorado Anschutz Medical Campus, DENVER, CO
*Purpose: To characterize the clinical course of patients diagnosed with acute on chronic liver failure (ACLF) before undergoing liver transplantation. ACLF is characterized by an…
2020 American Transplant Congress
Black Patients with Cirrhosis Have Worse Liver-Related Outcomes: A Large Multicenter Study
N. R. Mazumder¹, K. Atiemo², K. Jackson³, A. Daud⁴, A. Kho³, L. G. Gabra⁵, J. Levitsky¹, D. P. Ladner⁴
¹Gastroenterology and Hepatology, Northwestern University, Chicago, IL, ²Department of Surgery, Tulane Abdominal Transplant Institute, New Orleans, LA, ³Center for Health Information Partnerships, Northwestern University, Chicago, IL, ⁴Transplant Surgery, Northwestern University, Chicago, IL, ⁵Feinberg School of Medicine, Northwestern University, Chicago, IL
*Purpose: Racial disparity is influential in liver cirrhosis. Estimates of its magnitude have been limited by lack of large, longitudinal data that track patients from…
2020 American Transplant Congress
Galectin-3 as a Biomarker of Disease Severity in Acute-on-Chronic Liver Failure
E. Cervantes-Alvarez¹, F. Tejeda-Dominguez², M. Lizardo-Thiebaud², E. Alatorre-Arenas³, O. Méndez-Guerrero¹, S. Yarza-Regalado¹, D. Kershenobich¹, A. Torre¹, M. Vilatobá⁴, C. A. Huang⁵, N. Navarro-Alvarez¹
¹Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Molecular Biology, Panamerican University, School of Medicine, Mexico City, Mexico, ³University of the Americas Puebla, School of Medicine, Puebla, Mexico, ⁴Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁵Surgery, University of Colorado Anschutz Medical Campus, Denver, CO
*Purpose: A matter of great importance is the discovery of alternative diagnostic measures that can detect liver disease at an early stage, especially when at…
2019 American Transplant Congress
Early Cognitive Improvement One Month after Liver Transplant Measured by the NIH Toolbox
M. Kim¹, J. D. Peipert², K. J. Reid¹, E. M. Liotta¹, M. B. Maas¹, D. R. Ganger³, P. C. Zee¹, D. P. Ladner⁴
¹Neurology, Northwestern University, Chicago, IL, ²Medical Social Sciences, Northwestern University, Chicago, IL, ³Medicine, Northwestern University, Chicago, IL, ⁴Surgery, Northwestern University, Chicago, IL
*Purpose: Cognitive impairment (CI) is highly prevalent in liver cirrhosis. Improvement after liver transplant (LT) varies among patients, diminishing the benefits of LT for some.…
2019 American Transplant Congress
Outcomes Following Open Inguinal Hernia Repair in Liver Transplant versus Cirrhotic Patients
N. Siegel, A. Kernodle, S. DiBrito, T. Ishaque, D. Segev, J. Garonzik-Wang
Johns Hopkins, Baltimore, MD
*Purpose: Patients with cirrhosis are at an increased risk for post-operative complications after open inguinal hernia repair (OIHR). Conversely, liver transplant recipients (LTR) may have…
2019 American Transplant Congress
Utilization of DCD Donors >50 Years Old for Liver Transplantation
T. Chaly, K. Hoidal, C. Cashman, J. Brink, A. Mehrotra, W. Van der Werf
Arizona Transplant Associates, PC, Phoenix, AZ
*Purpose: End stage liver disease is becoming more prevalent in the United States with approximately 4.9 million adults carrying the diagnosis. It is estimated that…
2019 American Transplant Congress
Share 21 Rather Than Share 15: Balancing Transplant Opportunity without Compromising Waitlist Outcomes
S. Nagai¹, L. C. Chau¹, M. Abouljoud¹, K. Collins¹, S. Jafri², M. Safwan¹, D. Moonka²
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI, ²Gastroenterology, Henry Ford Hospital, Detroit, MI
*Purpose: We recently reported that, with the introduction of Meld-Na liver allocation, the score at which patients clearly benefit from liver transplant as opposed to…

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