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American Transplant Congress abstracts

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Articles tagged "knockout"

  • 2022 American Transplant Congress

    Histocompatibility Findings in the First Xenotransplants from a Pig to Deceased Human Recipient

    M. Mangiola, V. Tatapudi, J. Stern, Z. Stewart Lewis, B. Lonze, N. Ali, R. Montgomery

    Transplant Institute, NYU Langone Transplant Institute, New York, NY

    *Purpose: Humans lack α-1,3-Gal (α-gal) epitopes, and naturally occurring α-gal antibodies (Abs) cause hyperacute rejection of porcine xenografts. We conducted 2 successful xenotransplants in brain-dead…
  • 2022 American Transplant Congress

    Gm2a Regulates Memory Cd8+ T Cell Activation and Differentiation

    K. P. Tong1, K. M. Baecher2, C. R. Hartigan1, M. Ford3

    1Emory University Transplant Center, Emory University, Atlanta, GA, 2Department of Surgery, Emory University, Atlanta, GA, 3Emory University, Atlanta, GA

    *Purpose: In a clinical trial, patients who underwent kidney transplantation and were subsequently stable off tacrolimus immunosuppression exhibited increased Gm2a transcript in PBMC relative to…
  • 2022 American Transplant Congress

    Gm2a: A Novel Regulatory Pathway Controlling CD8+ T Cell Alloimmunity

    K. M. Baecher1, J. Bazzano1, K. Tong1, M. Fribourg2, P. Cravedi2, P. S. Heeger2, M. L. Ford1

    1Department of Surgery, Emory University, Atlanta, GA, 2Mount Sinai School of Medicine, New York, NY

    *Purpose: Transplant recipients experience lifelong immunosuppression, yet studies have shown that a subset of patients may be able to retain stable graft function even with…
  • 2022 American Transplant Congress

    Novel Drug Target Identified for Reversal of Renal Tubular Injury

    S. Sur, M. Kerwin, S. Pineda, M. Sarwal

    UCSF, San Francisco, CA

    *Purpose: Understanding the unique susceptibility of the human kidney tubule to oxidative cell stress and to identify compounds to support reversal of renal tubular damage.*Methods:…
  • 2022 American Transplant Congress

    Triple-Knockout Pig Red Blood Cells as Potential Sources for Blood Transfusion in Alloimmunized Patients with Sickle Cell Disease

    T. Yamamoto1, M. H. Bikhet2, H. Q. Nguyen2, Y. Cui2, M. Javed2, S. S. Raza2, D. Ayares3, H. Iwase2, H. Hara2, D. K. Cooper1

    1Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, 3Revivicor, Blacksburg, VA

    *Purpose: Blood transfusion remains important in the treatment of patients with sickle cell disease (SCD). However, alloimmunization after multiple blood transfusions is associated with patient…
  • 2022 American Transplant Congress

    Increased Baboon Chimerism After Peripheral Blood Stem Cell Infusion from a Novel GalTKO Pig with Functional Humanized Il-3 Receptor

    E. M. Duggan, N. P. Llore, J. M. Stern, H. Sakai, B. Piegari, K. Bruestle, D. Hajosi, B. Bhola, F. Huang, D. Ekanayake-Alper, D. H. Sachs, M. Sykes, R. J. Hawley, A. D. Griesemer

    Columbia University Irving Medical Center, New York, NY

    *Purpose: The purpose of this study was to investigate whether expression of a humanized IL-3 receptor (hCD123+hCD131) transgene in a GalTKO pig would improve levels…
  • 2022 American Transplant Congress

    First Report of Xenotransplantation from a Pig to Human Recipient

    J. Stern1, V. Tatapudi1, B. Lonze1, Z. Stewart1, M. Mangiola1, M. Wu1, S. Mehta1, E. Weldon1, R. Dieter1, N. Lawson1, A. Griesemer2, B. Parent1, G. Piper1, P. Sommer1, S. Cawthon1, B. Sullivan1, N. Ali1, R. A. Montgomery1

    1NYU Langone Transplant Institute, New York, NY, 2CUMC, New York, NY

    *Purpose: Xenotransplantation of genetically edited pig organs into human recipients can solve the global scarcity of organs for transplantation. Humans lack the α1,3-Gal glycan ubiquitously…
  • 2021 American Transplant Congress

    Alloreactive Memory T Follicular Helper Cells Rapidly Differentiate Into Effectors Independent of B Cell Memory Following Retransplantation

    S. Zeng, E. S. Crichton, I. R. Badell

    Department of Surgery, Emory, Atlanta, GA

    *Purpose: Donor-directed HLA antibodies are an important cause of renal allograft injury, but effective therapeutic options to prevent or eliminate donor-specific antibodies (DSA) do not…
  • 2021 American Transplant Congress

    Triple-Knockout Pig Red Blood Cells Are a Potential Alternative Source for Clinical Blood Transfusion

    T. Yamamoto1, M. H. Bikhet1, H. Q. Nguyen1, M. Javed1, D. Ayares2, H. Iwase1, H. Hara1, D. K. Cooper1

    1Xenotransplantation Program, Surgery, The University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA

    *Purpose: Triple-knockout (TKO) pig RBCs (pRBCs) may be an alternative source for clinical blood transfusion because almost humans have no preformed antibody to TKO pRBCs.…
  • 2021 American Transplant Congress

    Glycogen Synthase Kinase 3 Beta Regulates Distinctive Macrophage Subsets in the Activation and Resolution of Liver Ischemia Reperfusion Injury

    H. Zhang1, M. Ni2, J. Zhang1, H. Wang2, R. Busuttil1, J. Kupiec-Weglinski1, Y. Zhai1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Glycogen synthase kinase 3β (Gsk3β) differentially regulates pro- and anti-inflammatory programs in macrophages upon TLR stimulations. We have documented in a murine liver partial…
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