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Articles tagged "Kinases"

  • 2018 American Transplant Congress

    Hematopoietic Cell Kinase (Hck) Regulates Effector and Regulatory T Cell (Treg) Function

    S. Farouk,1 C. Wei,1 B. Das,2 P. Cravedi,1 B. Murphy.1

    1Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mt. Sinai, New York, NY; 2Department of Pharmacological Sciences, Icahn School of Medicine at Mt. Sinai, New York, NY.

    Background: We found that upregulation of Hck mRNA expression, an Src family tyrosine kinase, in surveillance graft biopsies of kidney transplant patients associates with an…
  • 2018 American Transplant Congress

    Glycogen Synthase Kinase 3 beta Regulates Liver Inflammation Activation and Resolution by Controlling AMPK Activities

    H. Wang,1,2 M. Ni,1,2 H. Zhou,2 L. Lu,2 R. Busuttil,1 J. Kupiec-Weglinski,1 Y. Zhai.1

    1Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; 2Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

    Background & Aims: Glycogen synthase kinase 3β (Gsk3β) is ubiquitously expressed with distinctive functions in different types of cells. Although its roles in regulating innate…
  • 2018 American Transplant Congress

    Lymph Node Stromal Laminins Modulate the Dynamic Balance of the Treg/Th17 Axis

    L. Li, T. Simon, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Wagner, J. Bromberg.

    University of Maryland, Baltimore, MD.

    Background: Tolerance and immunity are associated with differential expression of lymph node (LN) stromal laminins α4β1γ1 (411) and α5β1γ1 (511), respectively, which determine how alloreactive…

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