Articles tagged "Kinases"

2018 American Transplant Congress
Hematopoietic Cell Kinase (Hck) Regulates Effector and Regulatory T Cell (Treg) Function
S. Farouk,¹ C. Wei,¹ B. Das,² P. Cravedi,¹ B. Murphy.¹
¹Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mt. Sinai, New York, NY; ²Department of Pharmacological Sciences, Icahn School of Medicine at Mt. Sinai, New York, NY.
Background: We found that upregulation of Hck mRNA expression, an Src family tyrosine kinase, in surveillance graft biopsies of kidney transplant patients associates with an…
2018 American Transplant Congress
Glycogen Synthase Kinase 3 beta Regulates Liver Inflammation Activation and Resolution by Controlling AMPK Activities
H. Wang,^1,2 M. Ni,^1,2 H. Zhou,² L. Lu,² R. Busuttil,¹ J. Kupiec-Weglinski,¹ Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Background & Aims: Glycogen synthase kinase 3β (Gsk3β) is ubiquitously expressed with distinctive functions in different types of cells. Although its roles in regulating innate…
2018 American Transplant Congress
Lymph Node Stromal Laminins Modulate the Dynamic Balance of the Treg/Th17 Axis
L. Li, T. Simon, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Wagner, J. Bromberg.
University of Maryland, Baltimore, MD.
Background: Tolerance and immunity are associated with differential expression of lymph node (LN) stromal laminins α4β1γ1 (411) and α5β1γ1 (511), respectively, which determine how alloreactive…