Articles tagged "Kidney"

2018 American Transplant Congress
Risk of ESRD in Prior Living Kidney Donors
J. Wainright, A. Robinson, A. Wilk, D. Klassen, W. Cherikh, D. Stewart.
UNOS, Richmond, VA.
We studied development of End Stage Renal Disease (ESRD) in living kidney donors (LKDs) who donated in the US between 1994 and 2016 (n=123,523), using…
2018 American Transplant Congress
Comparison of Microvascular Inflammation in Renal Allograft Tissue between ABO Incompatible and ABO Compatible Kidney Transplantation
E. Ko,^1,2 B. Choi,^1,2 C. Park,^1,2 Y. Kim,^1,2 C. Yang,^1,2 B. Chung.^1,2
¹Transplant Research Center, College of Medicine, Seoul St.Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; ²Division of Nephrology, Department of Internal Medicine, College of Medicine, Seoul St.Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Background: Microvascular inflammation (MVI) is considered as a pathological marker for antibody-mediated rejection (AMR) in the presence of donor-specific antibody (DSA). We aimed to investigate…
2018 American Transplant Congress
Mortality of Live Kidney Donors in the UK: 15 Year Comparative Cohort Study
N. Krishnan,¹ L. Mumford,³ G. Lipkin,⁴ S. Fletcher,¹ I. Gupta,⁵ P. Gill,⁶ R. Ryan,⁷ N. Raymond.⁸
¹Renal Unit, University Hospitals Coventry & Warwickshire NHS Trust, Coventry, United Kingdom; ²Faculty of Health and Life Sciences, Coventry University, Coventry, United Kingdom; ³Statistics and Clinical Studies, Organ Donation and Transplant, National Health Services Blood and Transplant, Bristol, United Kingdom; ⁴Renal Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom; ⁵Renal Unit, Heartlands Hospital, Birmingham, United Kingdom; ⁶Unit of Academic Primary Care, University of Warwick, Coventry, United Kingdom; ⁷Primary Care, Primary Care, West Midlands, Birmingham, United Kingdom; ⁸Statistics, University Hospitals Coventry & Warwickshire NHS Trust, Coventry, United Kingdom.
To investigate the all-cause mortality o LDs in comparison with healthy controls.Ethics approval was in place to accrue data from database. Protocol reviewed and passed…
2018 American Transplant Congress
Hard-To-Place Kidney Offers: Granular Examination of Donor Risk Factors for Discard
R. Narvaez, J. Nie, K. Noyes, M. Leeman, L. Kayler.
Dept of Surgery, University at Buffalo, Buffalo, NY; Dept of Epidemiology and Environmental Sciences, University at Buffalo, Buffalo, NY; Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY.
Background: Deceased-donor kidney discard rates remain high. Understanding risk factors for discard is difficult since most analyses lack granularity and sufficient sample of high disease…
2018 American Transplant Congress
Histogenomics: Molecular Profiling of Kidney Biopsies Predict Delayed Graft Function
P. Rao,¹ D. Deo,¹ B. Fyfe-Kirschner,² R. Siderits.²
¹NJ Sharing Network, New Providence, NJ; ²Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
IntroductionHistologic assessments of donor renal biopsies for percentage global glomerulosclerosis, interstitial fibrosis and arterial sclerosis can predict renal graft failure post-transplant.The morphologic evaluation of renal…
2018 American Transplant Congress
mTORC2 Deficiency in CD11c⁺dendritic Cells Promotes Acute Kidney Injury
H. Dai,^1,2 A. Watson,¹ D. Fantus,¹ L. Peng,² A. Thomson,¹ N. Rogers.¹
¹Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh; ²Department of Urological Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, China.
Introduction: The role of the mammalian/mechanistic target of rapamycin (mTOR) in the pathophysiology of renal ischemia-reperfusion injury (IRI) is poorly characterized; furthermore, the influence of…
2018 American Transplant Congress
Impact of the Kidney Allocation System on Young Pediatric Recipients
W. Parker,¹ L. Ross,¹ J. Thistlethwaite,¹ A. Gallo.²
¹University of Chicago, Chicago, IL; ²Stanford University, Palo Alto, CA.
Purpose: The Kidney Allocation System (KAS) altered the priority of pediatric candidates for deceased donor kidney transplantation. Before long-term graft outcomes can be assessed, Delayed…
2018 American Transplant Congress
Clinical Validation of a Novel ELISpot-Based In Vitro Diagnostic Assay to Monitor CMV-Specific Cell-Mediated Immunity in Kidney Transplant Recipients
B. Banas,¹ D. Steubl,² L. Renders,² D. Chittka,¹ M. Banas,¹ T. Wekerle,³ M. Koch,⁴ O. Witzke,⁵ A. Muehlfeld,⁶ C. Sommerer,⁷ A. Habicht,⁸ C. Hugo,⁹ T. Huenig,¹⁰ M. Lindemann,⁵ T. Schmidt,¹¹ A. Rascle,¹¹ S. Barabas,¹¹ L. Deml,¹¹ R. Wagner,^1,11 B. Kraemer,¹² B. Krueger.¹²
¹University Clinic, Regensburg, Germany; ²Clinic rechts der Isar TUM, Munich, Germany; ³Medical University, Vienna, Austria; ⁴University Clinic, Hamburg-Eppendorf, Germany; ⁵University Hospital, Essen, Germany; ⁶Uniklinik RWTH, Aachen, Germany; ⁷University Hospital, Heidelberg, Germany; ⁸LMU Medical Center, Munich, Germany; ⁹University Hospital, Dresden, Germany; ¹⁰University Hospital, Wuerzburg, Germany; ¹¹Lophius Biosciences, Regensburg, Germany; ¹²UMM Uni. Heidelberg, Mannheim, Germany.
Impaired cytomegalovirus (CMV)-specific cell-mediated immunity (CMV-CMI) is a major cause ofCMV reactivation and associated complications in solid-organ transplantation. Reliably assessing CMV-CMI is desirable to individually…
2018 American Transplant Congress
Long-Term Effect of BMI on Renal Function in Asian Living Kidney Donors
J. Na,¹ J. Park,¹ M-.G. Yoon,¹ H. Lee,² Y. Yoon,³ K. Huh,⁴ M. Kim,⁴ S. Kim,⁴ Y. Kim,⁴ W. Han.¹
¹Department of Urology, Yonsei University College of Medicine, Urological Science Institute, Seoul, Korea; ²Department of Urology, National Health Insurance Service Ilsan Hospital, Goyang-si, Korea; ³Department of Urology, Hanyang University Medical Center, Seoul, Korea; ⁴Department of Surgery-Transplantation, Yonsei University College of Medicine, Seoul, Korea.
One of the targets of expanding criteria for kidney donation is BMI. As the impact of BMI differs in Asians, we studied the long-term effect…
2018 American Transplant Congress
Living Donor Nephrectomy: Is It as Safe as It Can Be? Analysis of Living Donor Deaths in the United States
D. Keith,¹ J. Brown,² K. Andreoni.³
¹Medicine, Sacred Heart Hospital, Pensacola, FL; ²President, Clinical Integration Solutions, LLC, Health Safety Consultancy Company, New York, NY; ³Surgery, University of Florida, Gainesville, FL.
The reported rate of death from living donor nephrectomy is 3 in 10,000 donations. Although this risk is low, the important question is how many…