Articles tagged "Kidney"

2018 American Transplant Congress
Histogenomics: Molecular Profiling of Kidney Biopsies Predict Delayed Graft Function
P. Rao,¹ D. Deo,¹ B. Fyfe-Kirschner,² R. Siderits.²
¹NJ Sharing Network, New Providence, NJ; ²Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
IntroductionHistologic assessments of donor renal biopsies for percentage global glomerulosclerosis, interstitial fibrosis and arterial sclerosis can predict renal graft failure post-transplant.The morphologic evaluation of renal…
2018 American Transplant Congress
mTORC2 Deficiency in CD11c⁺dendritic Cells Promotes Acute Kidney Injury
H. Dai,^1,2 A. Watson,¹ D. Fantus,¹ L. Peng,² A. Thomson,¹ N. Rogers.¹
¹Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh; ²Department of Urological Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, China.
Introduction: The role of the mammalian/mechanistic target of rapamycin (mTOR) in the pathophysiology of renal ischemia-reperfusion injury (IRI) is poorly characterized; furthermore, the influence of…
2018 American Transplant Congress
Impact of the Kidney Allocation System on Young Pediatric Recipients
W. Parker,¹ L. Ross,¹ J. Thistlethwaite,¹ A. Gallo.²
¹University of Chicago, Chicago, IL; ²Stanford University, Palo Alto, CA.
Purpose: The Kidney Allocation System (KAS) altered the priority of pediatric candidates for deceased donor kidney transplantation. Before long-term graft outcomes can be assessed, Delayed…
2018 American Transplant Congress
Clinical Validation of a Novel ELISpot-Based In Vitro Diagnostic Assay to Monitor CMV-Specific Cell-Mediated Immunity in Kidney Transplant Recipients
B. Banas,¹ D. Steubl,² L. Renders,² D. Chittka,¹ M. Banas,¹ T. Wekerle,³ M. Koch,⁴ O. Witzke,⁵ A. Muehlfeld,⁶ C. Sommerer,⁷ A. Habicht,⁸ C. Hugo,⁹ T. Huenig,¹⁰ M. Lindemann,⁵ T. Schmidt,¹¹ A. Rascle,¹¹ S. Barabas,¹¹ L. Deml,¹¹ R. Wagner,^1,11 B. Kraemer,¹² B. Krueger.¹²
¹University Clinic, Regensburg, Germany; ²Clinic rechts der Isar TUM, Munich, Germany; ³Medical University, Vienna, Austria; ⁴University Clinic, Hamburg-Eppendorf, Germany; ⁵University Hospital, Essen, Germany; ⁶Uniklinik RWTH, Aachen, Germany; ⁷University Hospital, Heidelberg, Germany; ⁸LMU Medical Center, Munich, Germany; ⁹University Hospital, Dresden, Germany; ¹⁰University Hospital, Wuerzburg, Germany; ¹¹Lophius Biosciences, Regensburg, Germany; ¹²UMM Uni. Heidelberg, Mannheim, Germany.
Impaired cytomegalovirus (CMV)-specific cell-mediated immunity (CMV-CMI) is a major cause ofCMV reactivation and associated complications in solid-organ transplantation. Reliably assessing CMV-CMI is desirable to individually…
2018 American Transplant Congress
Long-Term Effect of BMI on Renal Function in Asian Living Kidney Donors
J. Na,¹ J. Park,¹ M-.G. Yoon,¹ H. Lee,² Y. Yoon,³ K. Huh,⁴ M. Kim,⁴ S. Kim,⁴ Y. Kim,⁴ W. Han.¹
¹Department of Urology, Yonsei University College of Medicine, Urological Science Institute, Seoul, Korea; ²Department of Urology, National Health Insurance Service Ilsan Hospital, Goyang-si, Korea; ³Department of Urology, Hanyang University Medical Center, Seoul, Korea; ⁴Department of Surgery-Transplantation, Yonsei University College of Medicine, Seoul, Korea.
One of the targets of expanding criteria for kidney donation is BMI. As the impact of BMI differs in Asians, we studied the long-term effect…
2018 American Transplant Congress
Living Donor Nephrectomy: Is It as Safe as It Can Be? Analysis of Living Donor Deaths in the United States
D. Keith,¹ J. Brown,² K. Andreoni.³
¹Medicine, Sacred Heart Hospital, Pensacola, FL; ²President, Clinical Integration Solutions, LLC, Health Safety Consultancy Company, New York, NY; ³Surgery, University of Florida, Gainesville, FL.
The reported rate of death from living donor nephrectomy is 3 in 10,000 donations. Although this risk is low, the important question is how many…
2018 American Transplant Congress
Multiparametric MRI for Assessment of Renal Transplant Fibrosis: A Pilot
M. Menon, O. Bane, S. Lewis, R. Khaim, S. Florman, P. Kennedy, S. Hectors, V. Delaney, F. Salem, B. Taouli.
Recanati Miller Transplant Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Fibrosis in renal allografts confers risk of progression to allograft loss. The gold standard for evaluating renal fibrosis remains allograft biopsy, which is invasive, prone…
2018 American Transplant Congress
In Vivo Imaging and Function of Renal Tertiary Lymphoid Organs
K. Abou-Daya, D. Zhao, A. Williams, M. Oberbarnscheidt.
Starzl Transplantation Institute, Pittsburgh.
Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues in the setting of chronic inflammation such as organ transplantation. The function…
2018 American Transplant Congress
Estimated Impact of the Number of Simultaneous Offers on Kidney Delay and Discard
M. Mankowski,¹ S. Raghavan,³ C. Holscher,² M. Kosztowski,² D. Segev,² S. Gentry.⁴
¹King Abdullah University of Science and Technology, Thuwal, Saudi Arabia; ²Johns Hopkins University, Baltimore; ³University of Maryland, College Park; ⁴US Naval Academy, Annapolis.
Following local decline of a recovered kidney, making regional and national offers in larger simultaneous batches might decrease discards. We simulated varying batch sizes for…
2018 American Transplant Congress
SGLT2 Inhibition in Kidney Transplant Recipients with Diabetes
M. Guthoff,¹ M. Mahling,¹ S. Nadalin,² N. Heyne.¹
¹Dept. of Endocrinology and Diabetology, Angiology, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany; ²Dept. of General, Visceral and Transplant Surgery, University of Tübingen, Tübingen, Germany.
Purpose: Sodium-glucose cotransporter 2 (SGLT2) inhibition has been shown to reduce cardiovascular mortality and preserve kidney function in patients with type 2 diabetes. Kidney transplant…