Articles tagged "Kidney"

2019 American Transplant Congress
Sex Specific Regulation of Podocyte-Specific Genes and Proteins Determines Glomerular Response to mTOR Inhibition
A. Kusch¹, O. AlDiab², D. Gürgen², C. Sünkel³, F. Grahammer⁴, M. Rinschen⁵, T. Huber⁴, N. Rajewsky³, D. Dragun²
¹Medizinische Klinik m. S. Nephrologie und Internistische Intensivmedizin, Charité Universitätsmedizin Berlin, Berlin, Germany, ²Medizinische Klinik m. S. Nephrologie und internistische Intensivmedizin, Charité Universitätsmedizin Berlin, Berlin, Germany, ³Max-Delbrück Center for Molecular Medicine, Berlin, Germany, ⁴III. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg - Eppendorf, Hamburg, Germany, ⁵CECAD Research Center, Universitätsklinikum Köln, Köln, Germany
*Purpose: mTOR inhibitors are increasingly used in transplantation with high interindividual variation in proteinuric responses. Although males have higher prevalence and faster progression of glomerular…
2019 American Transplant Congress
Evaluation Of BK Polyomavirus Monitoring And Management In Kidney Transplant Recipients
M. Tomeczkowicz, S. Mondal, N. Sulejmani, B. Summers, T. Larson, A. Jantz
Henry Ford Hospital, Detroit, MI
*Purpose: BK polyomavirus (BKV) is an opportunistic infection that can lead to BKV nephropathy and premature graft loss within the first year post-transplant. The mainstay…
2019 American Transplant Congress
Exercise for Solid Organ Transplant Candidates and Recipients: A Joint Position Statement of the Canadian Society of Transplantation (CST) and Canadian Network for Rehabilitation and Exercise for Solid Organ Transplant Optimal Recovery (CAN-RESTORE)
T. Janaudis-Ferreira¹, S. Mathur², R. Deliva³, N. Howes⁴, C. Patterson⁵, A. Räkel⁶, S. So⁵, L. Wickerson⁷, M. White⁶, Y. Avitzur⁵, O. Johnston⁸, N. Heywood⁹, S. Singh⁷, S. Holdsworth¹⁰
¹School of Physical and Occupational Therapy, McGill University, Montreal, QC, Canada, ²University of Toronto, Toronto, ON, Canada, ³The Hospital for Sick Children, Toronto, ON, Canada, ⁴London Health Sciences Centre, London, ON, Canada, ⁵The Hospital For Sick Children, Toronto, ON, Canada, ⁶University of Montreal Hospital Centre, Montreal, QC, Canada, ⁷University Health Network, Toronto, ON, Canada, ⁸Vancouver General Hospital, Vancouver, BC, Canada, ⁹McGill University Health Centre, Montreal, QC, Canada, ¹⁰Canadian Donation and Transplantation Research Program, Edmonton, AB, Canada
*Purpose: Exercise training has been shown to be beneficial across several chronic disease groups that may lead to solid organ transplantation (SOT), and across organ…
2019 American Transplant Congress
Prognostic Value of C3d Fixing Preformed Donor-Specific Antibody in Crossmatch-Positive Living Kidney Transplantation
K. Miyake¹, M. Okumi¹, Y. Kakuta¹, K. Unagami², M. Furusawa¹, H. Ishida², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Sinjuku, Japan, ²Organ Transplant Medicine, Tokyo Women's Medical University, Sinjuku, Japan
*Purpose: The occurrence of acute antibody-mediated rejection (ABMR) was higher in flow cytometric crossmatch (FCXM)-positive patients despite desensitization, and complement binding ability of donor specific…
2019 American Transplant Congress
Simultaneous Pancreas and Kidney Transplant Outcomes after Induction Therapy with Thymoglobulin Compared with Alemtuzumab
B. Masters¹, F. Bartlett², C. Drachenberg³, S. Bartlett³, R. Barth³, J. Scalea³, A. Haririan³
¹University of Maryland Medical Center, Baltimore, MD, ²Barnes-Jewish Hospital, St. Louis, MO, ³University of Maryland, School of Medicine, Baltimore, MD
*Purpose: The purpose of this study is to compare the outcomes of simultaneous pancreas and kidney transplant (SPK) recipients after two T-cell depleting induction agents:…
2019 American Transplant Congress
The Complexity of T Cell-Mediated Rejection Scenarios: Identifying BK in Biopsies with TCMR
P. F. Halloran and The INTERCOMEX Investigators¹, G. Gupta², J. Reeve³
¹University of Alberta, Edmonton AB, AB, Canada, ²Virginia Commonwealth University, Richmond, VA, ³Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada
*Purpose: Some transplanted kidneys have concomitant T cell-mediated rejection (TCMR) and BK virus nephropathy (BK). The histologic diagnosis in BK sometimes overlooks the TCMR component,…
2019 American Transplant Congress
Identification of Antibodies Reactive to Vimentin in a Rat Kidney Transplant Model of Chronic Antibody-Mediated Rejection
S. Reese, N. Wilson, L. Ptak, J. Sullivan, W. Burlingham, A. Djamali, S. E. Panzer
University of Wisconsin Madison, Madison, WI
*Purpose: As many as 30% of patients with chronic active antibody-mediated rejection (cAMR) lack HLA-specific antibodies. Recently, researchers identified clinical relevance of non-HLA antibodies, including…
2019 American Transplant Congress
Clinical Implications of Belatacept Conversion in a High-Risk, Urban Renal Transplant Population
B. Valdepenas, J. Benken, E. Benedetti, Z. Hajjiri, A. Lichvar
University of Illinois at Chicago, Chicago, IL
*Purpose: Conversion to belatacept as maintenance immunosuppression has gained traction to prevent calcineurin inhibitor (CNI) induced toxicities in renal transplant (RTx) recipients. However, limited knowledge…
2019 American Transplant Congress
The Implications of Donor Proteinuria in Deceased Donor Kidney Transplantation
A. Vinson, T. Keough-Ryan, K. West, K. Tennankore
Dalhousie University, Halifax, NS, Canada
*Purpose: The implications of pre-terminal donor urinalysis findings on post-transplant kidney graft survival has not been previously explored. An abnormal donor urinalysis may reflect donor…
2019 American Transplant Congress
Standardized Pain Management Post Donor Nephrectomy Results in Decreased Length of Stay
N. Alvey¹, B. Hohoff², M. Brokhof¹, N. Kenyon¹, E. Hollinger³
¹Pharmacy, Rush University Medical Center, Chicago, IL, ²Transplant, Rush University Medical Center, Chicago, IL, ³Surgery, Rush University Medical Center, Chicago, IL
*Purpose: Laparoscopic donor nephrectomy has reduced the burden associated with open surgery, but a significant percentage of donors still suffer from postoperative pain. It is…