2022 American Transplant Congress
Biopsy and Blood Gene Expression Profiles Distinguish Injury, Subclinical and Clinical Rejection in Kidney Transplant Recipients
1Scripps Health, La Jolla, CA, 2Northwestern University, Chicago, IL
*Purpose: We analyzed serial gene expression profiles in paired blood and biopsies from kidney transplant recipients phenotyped with a comprehensive clinical algorithm. We compared disease…2022 American Transplant Congress
Protocolized, Broad-Based Renal Genetic Testing in the Management of Patients at a Transplant Center
*Purpose: Studies show that ~10% of adult chronic kidney diseases (CKD) cases have genetic etiologies. In the nephrology setting, the use of a broad, unbiased…2022 American Transplant Congress
Hepatitis C Positive Kidney Transplant Into Hepatitis C Negative Recipients
*Purpose: Kidney transplantation is the treatment of choice in end stage renal disease (ESRD). In 2018, 5% to 8% of eligible adults died while on…2022 American Transplant Congress
Infections Requiring Hospitalization After Simultaneous Pancreas-Kidney Transplantation Compared to Kidney Transplantation Alone
*Purpose: Although infections related to surgical complications are more common after simultaneous pancreas-kidney transplantation (SPK) compared to kidney transplantation alone (KTA), the burden of infections…2022 American Transplant Congress
The Evolution of Hypogammaglobulinemia in Kidney Transplant Recipients and Its Associated Risk Factors
*Purpose: Hypogammaglobulinemia (HGG) has been extensively studied to identify a biological marker for infection. According to Florescu et al. (2013), a meta-analysis of 18 clinical…2022 American Transplant Congress
Association Between Increased Overweight at First Year After Kidney Transplantation and Long-Term Kidney Graft Outcome
*Purpose: The obesity is increasing in chronic kidney disease patients and associated with poor renal outcome. The role of inflammation within the adipose tissue in…2022 American Transplant Congress
Semaglutide Tolerability and Efficacy in Patients with Chronic Kidney Disease Stage 4, 5 and End Stage Renal Disease
*Purpose: Obesity is often a barrier to kidney transplantation (KT) due to increased perioperative risks and worse outcomes with many transplant centers setting BMI cut…2022 American Transplant Congress
Focal Distribution of TCMR Causes False Negative Results in Spatially Resolved Molecular Diagnostic Assays
University of Pittsburgh, Pittsburgh, PA
*Purpose: Molecular assays on ~3mm biopsy (BX) fragments of cannot confirm histologic T-cell mediated rejection (TCMR) in ~50% of routine biopsies, and fail to detect…2022 American Transplant Congress
Socioeconomic Factors Influence Likelihood of Directed Living Donor Transplant Among Children with End-Stage Renal or Liver Disease
University of Colorado Anschutz Medical, Aurora, CO
*Purpose: Previous studies have demonstrated that children with public insurance are less likely to receive a transplant from a directed living donor. Type of insurance…2022 American Transplant Congress
The Impact of Neutralizing Antibodies on Polyomavirus Infections in Mice
Pathology and Laboratory Medicine, UNC Chapel Hill School of Medicine, Chapel Hill, NC
*Purpose: Definitive polyomavirus nephropathy (PyVN) affects kidney transplants and impacts allograft function and survival. Data suggest that neutralizing PyV strain specific antibodies can attenuate and…
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