Articles tagged "Kidney"

2019 American Transplant Congress
Center-Level Variation in HLA-Incompatible Living Donor Kidney Transplantation Outcomes
K. Jackson¹, J. Long¹, K. Covarrubias¹, J. Motter¹, M. Bowring¹, J. Chen¹, M. Waldram¹, B. Orandi², N. Desai¹, A. Massie¹, D. Segev¹, J. Garonzik-Wang¹
¹Johns Hopkins University, Baltimore, MD, ²University of Alabama School of Medicine, Birmingham, AL
*Purpose: Desensitization protocols for HLA-incompatible living donor kidney transplantation (ILDKT) vary across centers. The impact of these variations, as well as other practice variations, on…
2019 American Transplant Congress
Lineage Tracing Identifies C-Kit Cells as a Population of Kidney-Specific Stem Cells during Development and in Acute and Chronic Kidney Diseases
E. B. Rangel¹, E. Higuti-Sousa¹, G. Goss², B. Goldstein², B. Seidler³, D. Saur³, S. A Gomes⁴, J. M. Hare²
¹Albert Einstein Hospital, São Paulo, Brazil, ²University of Miami, Miami, FL, ³Medizinische Klinik, Technische Universität München, Munich, Germany, ⁴University of São Paulo, São Paulo, Brazil
*Purpose: We recently reported that c-Kit cells isolated from developing kidneys exhibit regenerative potential in mouse models of acute nephrotic syndrome and ischemia-reperfusion injury. These…
2019 American Transplant Congress
Predicting Post-Transplant Graft Function in Deceased Donor Kidney Transplant Recipients
K. Archer¹, Y. Zhang¹, V. Bontha², J. Eason³, L. Gallon⁴, E. Akalin⁵, D. Maluf², V. Mas²
¹OSU, Columbus, OH, ²UTHSC, Memphis, TN, ³UTHSC Director of Transplant Institute, Memphis, TN, ⁴NWU, Chicago, IL, ⁵Albert Einstein College of Medicine, NYC, NY
*Purpose: Discarding donor organs lengthens time patients spend on the kidney transplant (KT) wait list. To identify characteristics associated with short-term outcome in deceased donor…
2019 American Transplant Congress
Impact of an Intra-Abdominal Cooling Device during Open Kidney Transplantation in Pigs
A. Longchamp¹, R. P. Meier², N. Colucci³, A. Balaphas³, L. Orci³, A. Nastasi³, G. Longchamp¹, S. Moll⁴, A. Klauser⁵, F. Lazeyras⁵, M. Pascual⁶, J. Corpataux⁷, L. Bühler⁸
¹Department of Vascular Surgery, CHUV, Lausannne, Switzerland, ²Department of Surgery, University of California San Francisco, San Francisco, CA, ³Department of Surgery, HUG, Geneva, Switzerland, ⁴Department of Pathology, HUG, Geneva, Switzerland, ⁵Department of Radiology, HUG, Geneva, Switzerland, ⁶Department of Transplantation, CHUV, Lausannne, Switzerland, ⁷Department of Vascular Surgery, CHUV, Lausanne, Switzerland, ⁸Department of Surgery, CHUV, Lausannne, Switzerland
*Purpose: Renal transplantation is the preferred treatment for end-stage renal disease. Currently, there is a large gap between the supply and demand for transplantable kidneys.…
2019 American Transplant Congress
Evaluation of Rabbit Antithymocyte Globulin (rATG) Dosing and Incidence of Opportunistic Viral Infections in Kidney Transplant Recipients Using Tacrolimus (TAC), Mycophenolate (MPA) and Steroid Free Maintenance Immunosuppression
L. Von Stein, A. Leino, R. Amer, T. Pesavento, H. Winters
The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: There is limited literature evaluating rATG dosing and incidence of infection with TAC/MPA and early steroid withdrawal. This study evaluates rATG dosing and overall…
2019 American Transplant Congress
Activation of Renal Fibroblasts by Anti- Major Histocompatibility Complex Antibody: A Missing Link in Allograft Fibrosis
M. B. Oliver¹, J. Chen², A. Zmijewska¹, R. B. Mannon¹
¹Medicine, Division of Nephrology, The University of Alabama at Birmingham, Birmingham, AL, ²Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, AL
*Purpose: Chronic antibody-mediated rejection (CAMR) is an important contributor to late kidney allograft loss, frequently accompanied by interstitial fibrosis and tubular atrophy. Donor-specific antibodies (DSA)…
2019 American Transplant Congress
Impact of Clinical Trial Enrollment on Renal Transplant Outcomes
T. Shertel, A. Eisenhart
Saint Barnabas Medical Center, Livingston, NJ
*Purpose: The advancement of science and medicine begins with new therapies and techniques arriving through clinical trials. The possibility of improved patient outcomes may also…
2019 American Transplant Congress
Circulating De Novo Donor Specific Antibodies and Carotid Intima-Media Thickness in Pediatric Kidney Transplant Recipients
K. Sgambat¹, S. Clauss², A. Moudgil¹
¹Nephrology, Children's National, Washington DC, DC, ²Cardiology, Children's National, Washington DC, DC
*Purpose: Emerging evidence suggests that circulating de novo donor specific anti-HLA antibodies (dnDSA) may be associated with increased risk of accelerated systemic arteriosclerosis and major…
2019 American Transplant Congress
Racial and Ethnic Differences in Physician Trust and Hypertension Treatment Adherence among Living Kidney Donors in the United States
J. S. Wilson Jr¹, L. Cooper², M. Johnson², M. Waldram², Y. Yu², J. Perkins², D. Crews², N. Lacy³, M. Henderson², A. Massie², K. Lentine⁴, D. Segev², T. Purnell²
¹Williams College, Williamstown, MA, ²Johns Hopkins University, Baltimore, MD, ³North Carolina State University, Raleigh, NC, ⁴St. Louis University, St. Louis, MO
*Purpose: Among living kidney donors who develop hypertension (HTN), little is known about racial/ethnic differences in the relationship between physician trust levels and adherence to…
2019 American Transplant Congress
The Use of High Volume Perioperative Normal Saline Increases the Risk of Delayed Graft Function after Kidney Transplantation
K. Kolodzie¹, O. S. Cakmakkaya², E. S. Boparai³, M. Tavakol⁴, J. Feiner¹, C. U. Niemann⁵
¹Anesthesia & Perioperative Care, University of California San Francisco, San Francisco, CA, ²Dept. of Medical Education, University Istanbul – Cerrahpasa, Istanbul, Turkey, ³School of Medicine, George Washington University, Washington, DC, ⁴Dept. of Surgery, Division of Transplantation, University of California San Francisco, San Francisco, CA, ⁵Anesthesia & Perioperative Care, and Dept. of Surgery, Division of Transplantation, University of California San Francisco, San Francisco, CA
*Purpose: Metabolic and physiologic effects of high volume perioperative Normal Saline (NS) resuscitation are well described, but the impact on delayed graft function (DGF) remains…