Articles tagged "Kidney"

2020 American Transplant Congress
Serum αKlotho after Living Kidney Donation: A Systematic Review and Meta-Analysis
W. Cheungpasitporn¹, C. Thongprayoon², N. Leeaphorn³, M. A. Mao⁴, J. A. Neyra⁵
¹Nephrology, University of Mississippi Medical Center, Jackson, MS, ²Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ³Renal Transplant Program, University of Missouri-Kansas City School of Medicine/Saint Luke's Health System, Kansas City, MO, ⁴Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL, ⁵Nephrology, University of Kentucky, Lexington, KY
*Purpose: αKlotho (klotho) is a known anti-aging protein that exerts diverse physiological effects. Defect in klotho gene expression in mice can result in a syndrome…
2020 American Transplant Congress
Mesenchymal Stromal Cell Treatment of Kidneys During Normothermic Machine Perfusion is Safe and Feasible with Effective Traceability after Transplantation
K. Rozenberg¹, S. Lohmann², M. Pool³, M. Eijken⁴, U. Møldrup⁵, B. Møller⁶, J. Sierra-Parraga⁷, M. Hoogduijn⁷, L. Lo Faro¹, C. Moers³, J. Hunter¹, A. Keller², H. Leuvenink³, C. Baan⁷, R. Ploeg¹, B. Jespersen²
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ³Department of Surgery, University Medical Center Groningen, Groningen, Netherlands, ⁴Department of Renal Medicine, Aarhus University, Aarhus, Denmark, ⁵Department of Urology, Aarhus University, Aarhus, Denmark, ⁶Department of Clinical Immunology, Aarhus University, Aarhus, Denmark, ⁷Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands
*Purpose: Marginal kidneys are increasingly being accepted to decrease waiting time for a transplant. Normothermic machine perfusion (NMP) is a technique that allows delivery of…
2020 American Transplant Congress
“By the Time They Get to Me, I’ll Be Dead Anyway” – A Mixed-Methods Examination of Treatment Education & Decision-Making among Patients with Varying Amounts of Pre-End-Stage Renal Disease Nephrology Care
M. Urbanski¹, L. Dumenci¹, C. Gadegbeku², L. Siminoff¹, A. Waterman³, H. Gardiner¹
¹College of Public Health, Temple University, Philadelphia, PA, ²Lewis Katz School of Medicine, Section of Nephrology, Hypertension, and Kidney Transplantation, Temple University, Philadelphia, PA, ³UCLA, Division of Nephrology, Los Angeles, CA
*Purpose: The aim of this study was to explore renal replacement therapy (RRT) knowledge and decision-making experiences and preferences among patients with varying amounts of…
2020 American Transplant Congress
Combining New Biomarkers: Donor Derived Cell Free DNA (dd-cfDNA) and Transcriptomics Impacts Rejection Diagnosis, Treatment and Follow Up
S. Anand, L. Dong, D. Miller, I. Lloyd, D. Morris, T. Srinivas
Intermountain Medical Center, Murray, UT
*Purpose: Transcriptomics (Tr) is an emerging adjunct to traditional histological diagnosis (HDx) for kidney allograft rejection (KAR). We describe our experience of using Tr and…
2020 American Transplant Congress
The Effect of Desensitization Therapy on Sex Disparity in Living Kidney Transplantation
Y. Kakuta¹, M. Okumi¹, T. Kanzawa¹, K. Unagami², H. Ishida², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Organ Transplant Medicine, Tokyo Women's Medical University, Tokyo, Japan
*Purpose: Sex- and gender-based disparities which have shown women to have lower access to kidney transplantation have been reported. In living kidney transplantation (LKT), pregnancy-related…
2020 American Transplant Congress
Diagnostic Method of Acute Kidney Rejection after Transplantation Using Metabolome Analysis via a Liquid Biopsy Approach
H. Iwamoto
Department of Kidney Transplantation Surgery, Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan
*Purpose: At present, a definitive diagnosis of organ dysfunction after transplantation (such as acute rejection) is dependent on conventional histopathological evaluation using an invasive biopsy…
2020 American Transplant Congress
Parathyroidectomy Remains Effective for Treating Tertiary Hyperparathyroidism: Long-Term Results of a Randomized Study
A. Coloma¹, P. Moreno², J. Torregrosa³, N. Montero¹, A. Manonelles¹, E. Melilli¹, J. Cruzado¹
¹Nephrology, Hospital Universitari de Bellvitge, Hospitalet de LLobregat, Spain, ²Surgery, Hospital Universitari de Bellvitge, Hospitalet de LLobregat, Spain, ³Nephrology, Hospital Clinic, Barcelona, Spain
*Purpose: Tertiary hyperparathyroidism is a common cause of hypercalcemia after kidney transplant (KT). The aim of this study is to evaluate the long-term effectiveness of…
2020 American Transplant Congress
A Comparison of Temporal Gene Expression Patterns in Kidney, Heart, Liver, and Lung Transplant Biopsies
P. Halloran¹, J. Reeve¹, .. the INTERLUNG Study Group², .. the INTERHEART Study Group², .. the INTERLIVER Study Group², &. the INTERCOMEX Study Group²
¹University of Alberta, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: Gene expression patterns change with time post-transplant. The MMDx system makes it possible to do cross-organ comparisons using the same microarray platform and gene…
2020 American Transplant Congress
Activated Circulating Memory TFollicular Helper Cells with Self-Renewal Potential Underlie the Kidney Allograft Antibody-Mediated Rejection Response
K. Louis¹, C. Macedo¹, E. Bailly¹, B. Ramaswami¹, M. Marrari¹, T. Shi¹, D. Landsittel¹, U. Chandran¹, P. Fadakar¹, M. Yamada¹, G. Chalasani¹, P. Randhawa¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Inserm UMR 976, Paris, France
*Purpose: Antibody-mediated rejection (ABMR) is the leading cause of allograft failure after organ transplantation. Yet, the cellular events that lead to the induction of a…
2020 American Transplant Congress
Kidney Transplant Recipient Outcomes from Older (60+) Hypertensive Living Donors
A. Sharfuddin, T. Taber, O. Adebiyi, M. Panezai, D. Mishler, M. Yaqub
Indiana University School of Medicine, Indianapolis, IN
*Purpose: Although the data supporting long-term safety of nephrectomy in hypertensive donors has been reported, there is scarcity of long term data on the recipient…