Articles tagged "Kidney"

2020 American Transplant Congress
Safety of Belatacept in HIV-Positive Kidney Transplant Recipients
K. El Sakhawi¹, A. Scemla², D. Bertrand³, C. Garrouste⁴, P. Malvezzi⁵, P. Grimbert¹, M. Matignon¹
¹Nephrology, APHP Henri Mondor, Créteil, France, ²Nephrology, APHP Necker Enfants Malades, Paris, France, ³Nephrology, CHU Bois Guillaume, Rouen, France, ⁴Nephrology, CHU Clermond Ferrand, Clermont Ferrand, France, ⁵Nephrology, CHU Grenoble, Grenoble, France
*Purpose: Kidney allograft survival in HIV-infected patients is lower than in the general population. Belatacept (instead of anticalcineurins (CNI)) has been shown to have a…
2020 American Transplant Congress
Identifying Factors Associated with Delayed Graft Function Severity Using the OPTN Database
K. Checchi¹, D. Stewart², A. Toll², J. Case¹, S. Kurian¹, C. Marsh¹
¹Scripps Health, La Jolla, CA, ²United Network for Organ Sharing Research Department, Richmond, VA
*Purpose: Delayed graft function (DGF) is a costly adverse outcome in kidney transplantation with negative implications for both graft and patient survival. Identifying factors associated…
2020 American Transplant Congress
Reverse Epidemiology and the Obesity Paradox for Patients with Chronic Kidney Disease
R. A. Choudhury¹, D. Yoeli¹, H. B. Moore¹, H. Yaffe¹, G. Hoeltzel², K. R. Dumon³, N. N. Williams³, P. L. Abt⁴, K. D. Conzen¹, T. L. Nydam¹
¹Department of Surgery- Division of Transplantation Surgery, University of Colorado Hospital, Aurora, CO, ²Thomas Jefferson University Hospital, Philadelphia, PA, ³University of Pennsylvania Hospital, Philadelphia, PA, ⁴Department of Surgery- Division of Transplantation Surgery, University of Pennsylvania Hospital, Philadelphia, PA
*Purpose: Obesity has been associated with both increased progression of chronic kidney disease as well as with a paradoxical improvement in survival among ESRD patients…
2020 American Transplant Congress
Does the Distance from the Transplant Center Impact Kidney Transplant (KT) DGF, CIT and Outcomes?
M. Laftavi¹, O. Pankewycz², R. Shahbazov¹, A. Almonte¹, B. Gallay², J. Leggat², R. Hod Dvorai¹, C. Hubbell¹, S. Narsipur²
¹Transplant, Upstate Medical University, SYRACUSE, NY, ²Nephrology, Upstate Medical University, SYRACUSE, NY
*Purpose: Currently, there is an ongoing debate regarding the efficient use of available organs (utility) versus the fair access to transplant (equity). UNOS is now…
2020 American Transplant Congress
Impact of a De Novo Belatacept Based Immunosuppressive Regimen on Kidney Transplant Outcomes
K. Joyal, T. Vanhove, B. Schreiber, M. Cote, S. Shao, N. Elias, H. Gilligan, K. Safa, E. Heher, W. Williams, C. Rogers
Massachusetts General Hospital Transplant Center, Boston, MA
*Purpose: Use of anti-thymocyte globulin (rabbit) (rATG) induction with belatacept/mycophenolate (MPA)/prednisone based immunosuppression (IS) has led to a reduction in rejection compared to that seen…
2020 American Transplant Congress
Impact of Kidney Transplant Type and Previous Transplant on Baseline Donor-Derived Cell Free DNA
K. K. Sureshkumar, B. Chopra
Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA
*Purpose: Donor derived-cell free DNA (dd-cfDNA) is a biomarker useful in predicting acute rejection in renal allografts. The technology uses next generation sequencing and does…
2020 American Transplant Congress
Prevalence of Kidney Transplant-Associated Thrombotic Microangiopathy after ABO-Incompatible Kidney Transplantation
Y. Kakuta¹, M. Okumi¹, T. Kanzawa¹, K. Unagami², H. Ishida², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Organ Transplant Medicine, Tokyo Women's Medical University, Tokyo, Japan
*Purpose: Thrombotic microangiopathy (TMA) is a dangerous disorder characterized by fragmented red blood cells, decreased platelet count, and organ failure due to thrombosis. We investigated…
2020 American Transplant Congress
A Novel Polymer Product, APP-103, Reduces IRI-Induced Damage and Promotes Functional Improvement in Syngeneic Models of Renal Transplantation
K. Minami¹, S. Bae², H. Uehara¹, J. Iske¹, J. Reder³, H. Azuma⁴, A. Weins¹, E. Van Keuren⁵, B. Houser³, A. El-Khal¹, P. Kang², S. Tullius¹
¹Brigham and Women's Hospital, Boston, MA, ²Beth Israel Deaconess Medical Center, Boston, MA, ³Celdara Medical, Lebanon, NH, ⁴Osaka Medical College, Osaka, Japan, ⁵Georgetown University, Washington DC, DC
*Purpose: Our data introduce APP-103 as a novel, non-toxic and site-activating therapeutic approach that effectively ameliorates the consequences of ischemia/reperfusion injury in solid organ transplantation.*Methods:…
2020 American Transplant Congress
Quantifying the Number of ESRD Patients Who Might Benefit from Bariatric Surgery to Achieve Listing for Transplant
B. Orandi¹, P. MacLennan¹, S. Mehta¹, J. Grams¹, R. Stahl¹, R. Cannon¹, D. Anderson¹, M. Hanaway¹, C. Young¹, J. Purvis¹, N. Terrault², C. Lewis¹, J. Locke¹
¹University of Alabama at Birmingham, Birmingham, AL, ²University of Southern California, Los Angeles, CA
*Purpose: Mounting evidence suggests bariatric surgery may play a role in helping obese ESRD patients achieve sufficient weight loss to be transplant-eligible. We sought to…
2020 American Transplant Congress
Hematopoietic Cell Kinase Promotes Kidney Fibrosis Through Autophagy Pathway
C. Wei, L. Mou, K. Banu, M. Menon, W. Zhang, C. He, B. Murphy
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: In our previous studies, we identified hematopoietic cell kinase (HCK) as a key driver of renal fibrosis through TGFβ/Smad3 pathway. Here in this study,…