Articles tagged "Kidney"

2020 American Transplant Congress
A Comparison of Temporal Gene Expression Patterns in Kidney, Heart, Liver, and Lung Transplant Biopsies
P. Halloran¹, J. Reeve¹, .. the INTERLUNG Study Group², .. the INTERHEART Study Group², .. the INTERLIVER Study Group², &. the INTERCOMEX Study Group²
¹University of Alberta, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: Gene expression patterns change with time post-transplant. The MMDx system makes it possible to do cross-organ comparisons using the same microarray platform and gene…
2020 American Transplant Congress
Activated Circulating Memory TFollicular Helper Cells with Self-Renewal Potential Underlie the Kidney Allograft Antibody-Mediated Rejection Response
K. Louis¹, C. Macedo¹, E. Bailly¹, B. Ramaswami¹, M. Marrari¹, T. Shi¹, D. Landsittel¹, U. Chandran¹, P. Fadakar¹, M. Yamada¹, G. Chalasani¹, P. Randhawa¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Inserm UMR 976, Paris, France
*Purpose: Antibody-mediated rejection (ABMR) is the leading cause of allograft failure after organ transplantation. Yet, the cellular events that lead to the induction of a…
2020 American Transplant Congress
Kidney Transplant Recipient Outcomes from Older (60+) Hypertensive Living Donors
A. Sharfuddin, T. Taber, O. Adebiyi, M. Panezai, D. Mishler, M. Yaqub
Indiana University School of Medicine, Indianapolis, IN
*Purpose: Although the data supporting long-term safety of nephrectomy in hypertensive donors has been reported, there is scarcity of long term data on the recipient…
2020 American Transplant Congress
Age- and Sex-Mediated Differences in T Lymphocyte Populations of Kidney Transplant Recipients
R. Dziarmaga¹, D. Ke¹, V. Phan², H. Cardinal³, R. Sapir-Pichhadze¹, C. A. Piccirillo¹, B. Mazer¹, B. Foster¹
¹Research Institute - McGill University Health Centre, Montreal, QC, Canada, ²Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada, ³Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada
*Purpose: Kidney allograft failure rates peak between 17 to 24 years of age and are higher in young female than male kidney transplant recipients (KTR).…
2020 American Transplant Congress
Impact of Focal Cortical Necrosis (CN) in Preimplantation Biopsy (PBx) on Outcomes after Deceased Donor Kidney Transplantation
S. S. Nair, J. Ninan, R. Heilman, K. Reddy, M. Smith
Mayo Clinic, Phoenix, AZ
*Purpose: The data on outcomes of focal CN in PBx after deceased donor transplantation is sparse. We studied the prognostic value of focal CN on…
2020 American Transplant Congress
Long-Term Kidney Graft Survival is Superior with Simultaneous-Liver Kidney (SLK) Transplants Than Kidney Alone (KA) or Kidney after Liver (KALi) Transplants in the United States
N. Lim¹, S. M. Riad¹, S. Jackson², J. Lake¹
¹University of Minnesota, Minneapolis, MN, ²M Health Fairview, Minneapolis, MN
*Purpose: There is a concern that SLK transplant recipients have worse outcomes resulting in poor utilization of the kidney donor pool. We utilized the Scientific…
2020 American Transplant Congress
Sex Differences in Transplant Decision-Making
A. Wasim¹, H. Rafiqzad¹, M. Dastgheib¹, H. Ford¹, S. Macanovic¹, K. Wernerowski¹, S. Aghamohammadi¹, M. Novak¹, A. D. Waterman², I. Mucsi¹
¹University Health Network, Toronto, ON, Canada, ²University of California, Los Angeles, Los Angeles, CA
*Purpose: We examined the relationship between sex and the relative importance of pros and cons in kidney transplant (KT) decision making.*Methods: A convenience sample of…
2020 American Transplant Congress
Combining New Biomarkers: Donor Derived Cell Free DNA (dd-cfDNA) and Transcriptomics Impacts Rejection Diagnosis, Treatment and Follow Up
S. Anand, L. Dong, D. Miller, I. Lloyd, D. Morris, T. Srinivas
Intermountain Medical Center, Murray, UT
*Purpose: Transcriptomics (Tr) is an emerging adjunct to traditional histological diagnosis (HDx) for kidney allograft rejection (KAR). We describe our experience of using Tr and…
2020 American Transplant Congress
The Effect of Desensitization Therapy on Sex Disparity in Living Kidney Transplantation
Y. Kakuta¹, M. Okumi¹, T. Kanzawa¹, K. Unagami², H. Ishida², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Organ Transplant Medicine, Tokyo Women's Medical University, Tokyo, Japan
*Purpose: Sex- and gender-based disparities which have shown women to have lower access to kidney transplantation have been reported. In living kidney transplantation (LKT), pregnancy-related…
2020 American Transplant Congress
Diagnostic Method of Acute Kidney Rejection after Transplantation Using Metabolome Analysis via a Liquid Biopsy Approach
H. Iwamoto
Department of Kidney Transplantation Surgery, Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan
*Purpose: At present, a definitive diagnosis of organ dysfunction after transplantation (such as acute rejection) is dependent on conventional histopathological evaluation using an invasive biopsy…