Articles tagged "Kidney"

2021 American Transplant Congress
The Impact of 4-weeks of Supervised Exercise on Frailty and Lower Extremity (LE) Function in Patients with Advanced Chronic Kidney Disease (CKD)
E. Lorenz, L. Hickson, R. Weatherly, K. Thompson, M. Hogan, C. Kennedy
Mayo Clinic, Rochester, MN
*Purpose: Although frailty is a modifiable risk factor for morbidity and mortality among kidney transplant (KT) candidates, the optimal duration of effective prehabilitation interventions is…
2021 American Transplant Congress
Efficacy of MAU868, a Novel BKV Neutralizing Monoclonal Antibody (mAb), for the Treatment of Severe BK Virus Nephropathy (BKVN) After Kidney Transplant
S. C. Jordan¹, N. Ammerman², M. Toyoda³, K. Lim², J. R. Abend⁴, A. Patick⁵, M. R. Hodges⁵, A. Vo², S. J. Kovacs⁶
¹Comprehensive Transplant Center, Cedars Sinai Medical Ctr, West Hollywood, CA, ²Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, ³Cedars Sinai Medical Ctr, Los Angeles, CA, ⁴Novartis Institutes for BioMedical Research, Virology Research, Emeryville, CA, ⁵Amplyx Pharmaceuticals, San Diego, CA, ⁶Novartis Institutes for BioMedical Research, Translational Medicine, East Hanover, NJ
*Purpose: BKV reactivation leading to nephropathy and allograft loss in kidney transplant (KT) recipients remains a clinical significant concern. No specific or effective anti-BKV therapies…
2021 American Transplant Congress
Versatile Strategy to Enhance Nanomedicine Delivery to Graft Endothelial Cells
C. Albert¹, L. G. Bracaglia¹, A. Koide², J. DiRito¹, T. Lysyy¹, C. Edwards¹, J. T. Langford¹, D. Haakinson¹, S. A. Hosgood³, M. L. Nicholson³, J. S. Pober¹, W. M. Saltzman¹, S. Kiode², G. Tietjen¹
¹Yale University, new haven, CT, ²Perlmutter Cancer Center, New York University, Langone Medical Center, New York, NY, ³University of Cambridge, Cambridge, United Kingdom
*Purpose: Efficient delivery of therapeutics to graft endothelial cells (EC) can potentially render organs more resistant to injury, improving clinical outcomes. Specific targeting of polymeric…
2021 American Transplant Congress
Covid vs Non Covid Pneumonia in Kidney Transplant Recipients
R. Prashar, N. Khoury, P. Shrivastava, S. Yeddula, T. Kitajima, E. Ulrich, M. Ramesh, A. Patel, S. Nagai, M. Samaniego-Picota
Henry Ford Hospital, Detroit, MI
*Purpose: Compare clinical characteristics and outcomes in kidney transplant recipients (KTRs) hospitalized with COVID vs Non COVID Pneumonia.*Methods: This is a retrospective case‐control study examining…
2021 American Transplant Congress
The Impact of High Kdpi on 1-year Post-transplant Graft Function and Survival in a Brazilian Cohort
H. Tedesco Silva Junior, R. Demarchi Foresto, M. Hazin, B. Cassão, A. Aquino, J. Taddeo, C. Rosso Felipe, L. Requião Moura, J. Medina
Núcleo de Ensino e Pesquisa, Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil
*Purpose: To evaluate the impact of High Kidney Donor Profile Index (KDPI) on 1-year post-transplant renal function and graft survival.*Methods: This retrospective cohort analyzed 3,059…
2021 American Transplant Congress
Which Living Kidney Donors Arrive to the Donation Process Informed About Surgery?
L. Malinzak, A. Segal, R. Prashar, M. Jesse
Henry Ford Hospital, Detroit, MI
*Purpose: To evaluate perceived knowledge about surgery in potential living kidney donors embarking on the donation process.*Methods: Potential living kidney donors were surveyed about their…
2021 American Transplant Congress
Clazakizumab (clz, Anti-il-6 Antibody) Treatment Affects Il-6/il-6r Signaling by Increasing Soluble Gp130 (sgp130) in Hla-sensitized Kidney Transplant Patients (hs Ktx Pts) Treated for Chronic Antibody-mediated Rejection (cabmr)
B. Shin, S. Ge, A. Jimenez, N. Ammerman, A. Vo, R. Zhang, S. C. Jordan, M. Toyoda
Cedars-Sinai Medical Center, Cerritos, CA
*Purpose: IL-6 is a pro-inflammatory cytokine responsible for chronic vascular inflammation and a promising target for cABMR modulation. IL-6/sIL-6R complex initiates more pathogenic trans-signaling pathways…
2021 American Transplant Congress
Wound Infection After Kidney Transplantation: A Single Center Study
A. Demirag, J. Oberholzer, A. Agarwal, B. Rawashdeh, E. McCraken, K. Brayman
Transplantation, University of Virginia Medical Cener, Charlottesville, VA
*Purpose: Wound complications (WC) following kidney transplantation (KTx) consume valuable resources and may be associated with inferior short and long term graft outcomes. Known risk…
2021 American Transplant Congress
Kidney Transplant Recipients Who Had Covid-19 Prior to Transplant: A Single-center Experience
S. Sultan, M. Aull, R. Craig-Schapiro, E. C. Liu, J. H. Lee, S. Kapur
New York Presbyterian / Weill Cornell, New York, NY
*Purpose: In the early recovery phase after the initial surge of the COVID-19 pandemic, a question emerged in the context of resuming transplant activity: should…
2021 American Transplant Congress
One-year Outcomes of a Multicenter Trial of Transplantation of Hcv Viremic Kidney Donors into Hcv Uninfected Recipients
M. Sise¹, D. Goldberg², D. Schaubel³, J. Kort⁴, R. Alloway⁵, J. Friedewald⁶, R. Fontana⁷, S. Sultan⁸, N. Desai⁹, R. Chung¹, P. Reese¹⁰
¹Mass General Hospital, Boston, MA, ²U-Miami, Miami, FL, ³U. Pennsylvania, Philadelphia, PA, ⁴Abbvie, Chicago, IL, ⁵U Cincinnati, Cincinnati, OH, ⁶Northwestern U., Evanston, IL, ⁷U. Michigan, Ann Arbor, MI, ⁸Cornell, New York City, NY, ⁹Johns Hopkins, Baltimore, MD, ¹⁰U. Pennslyvania, Philadelpha, PA
*Purpose: As interest in transplantation of Hepatitis C virus (HCV)-viremic kidneys into HCV-uninfected (HCV+ to HCV- KT) recipients increases, understanding clinical outcomes beyond HCV clearance…