Articles tagged "Kidney"

2021 American Transplant Congress
De Novo Atypical Hemolytic Uremic Syndrome (aHUS) in Kidney Transplant Recipients from the Same Donor: Possible Role of Two Genetic Hits
C. Crane¹, J. Sherbotie², S. Anand³
¹University of California at San Diego, San Diego, CA, ²University of Utah School of Medicine, Salt Lake City, UT, ³Nephrology Associates of Utah, Salt Lake City, UT
*Purpose: Thrombotic microangiopathy (TMA) is an uncommon and potentially serious complication of kidney transplantation. Atypical hemolytic uremic syndrome (aHUS) is a type of TMA most…
2021 American Transplant Congress
Dynamic Forecasting of Patient-Specific Kidney Transplant Function with a Sequence-to-Sequence Deep-Learning Model
E. Van Loon¹, W. Zhang², A. Van Craenenbroeck¹, B. De Moor², M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²ESAT Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium
*Purpose: Alike other clinical biomarkers, eGFR trajectories are characterized by intra-individual variability, related to biological fluctuations and analytical error. These fluctuations hamper the distinction between…
2021 American Transplant Congress
Racial and Ethnic Disparities in Pediatric Kidney Transplantation – Has KAS Made a Difference?
O. Charnaya¹, S. Yu², A. Goldberg³, J. Garonzik-Wang², D. Segev², P. Verghese⁴
¹Pediatrics, Johns Hopkins University, Baltimore, MD, ²Transplant Surgery, Johns Hopkins University, Baltimore, MD, ³University of Manitoba, Winninpeg, MB, Canada, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Racial and ethnic minority pediatric transplant candidates have known disparities in access to kidney transplantation. The Kidney Allocation System (KAS), implemented in 2014, was…
2021 American Transplant Congress
Covid-19 Incidence Was Initially Associated with Posttransplant Kidney Graft Failure
A. Wey¹, J. Miller¹, D. Musgrove¹, N. Salkowski¹, M. Tabaka¹, R. Hirose², A. Massie³, D. Segev³, A. Israni¹, J. Snyder¹, B. Kasiske¹
¹SRTR, Minneapolis, MN, ²Univ of San Francisco, San Francisco, CA, ³Johns Hopkins, Baltimore, MD
*Purpose: To better understand the effect of COVID-19 on kidney posttransplant outcomes, we estimated the association of county-level COVID-19 incidence with kidney posttransplant graft failure.*Methods:…
2021 American Transplant Congress
Tissue-Specific Features of Immunity Revealed by Single-cell RNA Sequencing of Healthy Human Kidney
S. Q. Crome¹, J. M. Szusz², C. McEvoy¹, J. An¹, S. Clotet-Freixas¹, S. A. MacParland¹, G. D. Bader³, A. Konvalinka¹
¹Toronto General Hospital Research Institute, Ajmera Transplant Centre, University Health Network and the University of Toronto, Toronto, ON, Canada, ²Immunology, University of Toronto, Toronto, ON, Canada, ³Molecular Genetics, University of Toronto, Toronto, ON, Canada
*Purpose: Tissue-resident immune cells reside within distinct niches across organs, where they sustain tissue homeostasis and rapidly respond to perturbations in the local microenvironment. Across…
2021 American Transplant Congress
Outcomes Among CMV Mismatched and Highly Sensitized Kidney Transplant Recipients Who Develop Leukopenia or Neutropenia
S. Brar¹, R. Berry², A. Raval³, Y. Tang³, F. Vincenti², N. Skartsis²
¹University of British Columbia, Vancouver, BC, Canada, ²University of California, San Francisco, San Francisco, CA, ³Merck and Co., Inc., Kenilworth, NJ
*Purpose: Kidney transplant recipients (KTRs) who receive antiproliferative agents for immunosuppression and valganciclovir for CMV prophylaxis are at high risk of developing leukopenia and neutropenia.…
2021 American Transplant Congress
Health-related Quality of Life (HRQoL) in Patients on Dialysis and Kidney Transplant Recipients – Experience with the PROMIS Global-10 Survey
G. Chawla, W. Hajjar, M. Dastgheib, N. Yanga, G. Ahmadzadeh, N. El-Dassouki, A. Shahreza, N. Al Kaabi, N. Edwards, I. Mucsi
University Health Network, Division of Nephrology and Multi-Organ Transplant Program, Toronto, ON, Canada
*Purpose: The PROMIS (Patient-Reported Outcomes Measurement Information System) Global-10 survey has been used to assess HRQoL in population surveys and studies including patients with chronic…
2021 American Transplant Congress
Living Donor Total Robotic Renal Transplantation: Early Single Center Experience
M. E. Tobon Lascano, S. Koganti, M. E. Akoad, M. Anastopoulos, C. J. Simon, B. A. Bouthot, E. D. Walshe, Y. L. Cheah
Transplant, Lahey Clinic, Burlington, MA
*Purpose: To establish the feasibility and evaluate the results and outcomes of a newly established totally robotic kidney transplant program.*Methods: Retrospective review of a single…
2021 American Transplant Congress
Characterization of Chronic Renal Allograft Dysfunction at Single Cell Resolution
C. Kuscu¹, C. Kuscu², A. Shetty³, M. Talwar⁴, J. Eason², D. G. Maluf⁵, V. Mas⁶
¹Surgery, James D Eason Transplant Institute, UTHSC, Memphis, TN, ²Surgery, James D Eason Transplant Institute, Memphis, TN, ³Institute for Genome Sciences, School of Medicine, University of Maryland, Baltimore, MD, ⁴Nephrology, James D Eason Transplant Institute, Memphis, TN, ⁵Surgery, Program in Transplantation - University of Maryland, Baltimore, MD, ⁶Surgery, Division of Surgical Science - University of Maryland, Baltimore, MD
*Purpose: Chronic allograft dysfunction (CAD) is one of the major complications after kidney transplantation. Hereby, we aim to assess the molecular and cellular mechanism of…
2021 American Transplant Congress
One-Year Monitoring of Changes to Kidney-Pancreas Waiting Time Criteria: An OPTN Analysis
R. C. Forbes¹, B. Plucinski², J. White², N. T. Kyaw², R. Kandaswamy³, S. V. Niederhaus⁴
¹Surgery, Vanderbilt University, Nashville, TN, ²UNOS, Richmond, VA, ³Surgery, University of Minnesota, Minneapolis, MN, ⁴Surgery, University of Maryland, Baltimore, MD
*Purpose: In 2018, the OPTN board approved changes to kidney-pancreas (KP) waiting time criteria. KP candidates accrued waiting time if they were (1) on insulin…