Articles tagged "Kidney"

2022 American Transplant Congress
Kidney Allograft Injury is Reflected in the DNA Cargo of Urinary Extracellular Vesicles
I. Sedej¹, M. Štalekar², M. Tušek Žnidarič², K. Goričar³, N. Kojc⁴, P. Kogovšek², V. Dolžan³, M. Lenassi³, M. Arnol¹
¹Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Department of Biotechnology and Systems Biology, National Institute of Biology, Ljubljana, Slovenia, ³Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia, ⁴Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
*Purpose: Following cell injury, donor-derived cell-free DNA (ddcfDNA) is increased in the urine of kidney transplant recipients. DNA containing urinary extracellular vesicles (uEVs) are relevant…
2022 American Transplant Congress
Early Detection of Acute Rejection by Urine QSant is Not Confounded by Post-Transplant Time
C. Baan¹, S. Ghosh², J. Verhoeven¹, D. Hesselink¹, K. Boer¹, M. Sarwal²
¹Erasmus MC, Rotterdam, Netherlands, ²NephroSant, Brisbane, CA
*Purpose: We explore the viability of urinary biomarker-based monitoring for rejection in early days following renal transplantation.*Methods: Patients are from the Erasmus MC and received…
2022 American Transplant Congress
Outcomes of Kidney Transplants in Children: A Single-Center Experience
S. Shaikhouni¹, C. Hanna², I. Sekhon¹, H. Amer¹, M. Prieto³, C. H. Cramer²
¹Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ²Pediatric Nephrology and Hypertension, Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ³Division of Transplantation Surgery, Department of Medicine, Mayo Clinic, Rochester, MN
*Purpose: Over the past decades, immunosuppression regimen protocols, surgical techniques, and outcomes in pediatric kidney transplants (PKT) have evolved. This study describes our center’s experience…
2022 American Transplant Congress
Establishing a Framework for Long-Term Follow-Up: A Survey of Perspectives and Preferences of Living Kidney Donors
S. K. Singh¹, N. Caton², O. Johnston², C. S. Hanson³, A. Dominello³, K. Yetzer⁴, D. Chang², A. Tong³, J. S. Gill²
¹Department of Medicine, University of Toronto, Toronto, ON, Canada, ²Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ³Sydney School of Public Health, University of Sydney, Sydney, Australia, ⁴Canadian Blood Services, Ottawa, ON, Canada
*Purpose: There is currently no established standard for long-term follow-up of living kidney donors in Canada. To inform a new national standard, we sought to…
2022 American Transplant Congress
Unravelling the Stage-Shift of Acute Rejection by Urine QSant
W. Yazar¹, N. Titzler¹, R. Sarwal¹, M. Sarwal², S. Ghosh¹
¹Nephrosant, Brisbane, CA, ²NephroSant, Brisbane, CA
*Purpose: Suboptimal performance in current methods for allograft monitoring underscores the unmet need for enhanced immunosurveillance accuracy, to uncover the alloimmunity flux. QSant[Yang et al,…
2022 American Transplant Congress
Microvascular Inflammation without Antibody Mediated Rejection in Renal Transplantation
J. Bou Saba, R. Chowdhury, R. Mehta, K. I. Abou-Daya, S. Hariharan, A. Cherukuri
Thomas E. Starzl Transplantation Institute, UPMC, Pittsburgh, PA
*Purpose: Microvascular inflammation (MVI) defined by glomerulitis (g) and peritubular capillaritis (ptc) is a hallmark of ABMR in renal transplantation. The prevalence and significance of…
2022 American Transplant Congress
Infections in Kidney Transplant Recipients on Belatacept versus Tacrolimus-Based Immunosuppression
S. Gattis¹, A. Basu²
¹Emory Healthcare, Atlanta, GA, ²Emory University Hospital, Atlanta, GA
*Purpose: Patients 70 years and older with advanced/ end stage kidney disease are increasingly receiving kidney transplants. Immediately post- transplant, our center utilizes Belatacept coupled…
2022 American Transplant Congress
Utility of Genetic Testing in Kidney Transplant Evaluation
N. Singh¹, A. Palermini², A. Qamar¹, M. S. Naseer¹, H. Shokouh-Amiri¹, G. Zibari¹, D. Aultman¹, L. Beretich³, D. Luksic³, J. Gibson³, S. McCormick³, H. Tabriziani³, P. Billings³
¹Willis Knighton Physician's Network, John C. McDonald Regional Transplant Center, Shreveport, LA, ²Arkansas College of Osteopathic Medicine, Fort Smith, AR, ³Natera, Inc., Austin, TX
*Purpose: Genetic testing is an emerging tool in pre-kidney transplant (KT) evaluations for individuals with end-stage renal disease (ESRD). A known genetic etiology can inform…
2022 American Transplant Congress
A Pathway for Establishing Etiology of Kidney Failure: An Academic Transplant Center’s Experience with a Broad Kidney Gene Panel
R. Sodhi¹, K. Brossart², A. Desai¹, D. J. Arwindekar¹, H. Tabriziani², S. Akkina¹
¹Loyola University Medical Center, Maywood, IL, ²Natera, Inc., Austin, TX
*Purpose: Assessing genetic causes of kidney failure can inform pre-transplant decision making and may improve post-transplant outcomes. Here we describe an academic transplant center’s experience…
2022 American Transplant Congress
Outcome of Donor Derived and Community Acquired West Nile Infections in Kidney Transplant Recipients
R. K. Thimmisetty¹, G. Larrieux², S. Wilson², F. Barrantes¹, S. Kundeling¹, J. Kumar¹
¹Renal Medicine Associates, Albuquerque, NM, ²Presbyterian Health Services, Albuquerque, NM
*Purpose: Donor derived West Nile Virus(WNV) Infections can occur but rare. We are presenting four cases that were seen at our transplant center*Methods: Case 1:…