Articles tagged "Kidney"

2022 American Transplant Congress
RNA-Sequencing Analysis of Kidney Allografts Reveal Heightened NK Cell Activity in Chronic Active Antibody-Mediated Rejection
Y. Shah, E. Varma, S. Rahim, C. Li, C. Snopkowski, C. Hughes, D. M. Dadhania, S. Salvatore, S. V. Seshan, O. Elemento, M. Suthanthiran, T. Muthukumar
Weill Cornell Medicine, New York, NY
*Purpose: The role of NK cells is increasingly recognized in chronic active antibody mediated rejection (caABMR) of the kidney allograft. Treatment of caABMR is challenging…
2022 American Transplant Congress
Reasons for Kidney Transplant Patients to Have Outpatient Urine Cultures in the First Year Post-Transplant: An Analysis of the USRDS
V. Hemmige¹, E. Akalin², M. Kinkhabwala³
¹Montefiore Medical Center, Bronx, NY, ²Albert Einstein College of Medicine, Montefiore Medical Ctr, Bronx, NY, ³Albert Einstein College of Medicine, Bronx, NY
*Purpose: Urine cultures are frequently sent in the first year after kidney transplant, but the reasons that testing is done post-transplant is not well understood.…
2022 American Transplant Congress
Antibody Response to Sars-CoV-2 Vaccine Among Kidney Transplant Recipients: A Retrospective Cohort Study
H. Ishida¹, K. Unagami², K. Ishii³, T. Kanzawa², T. Yagisawa⁴, K. Tanabe², M. Furusawa²
¹Tokyo Women's, Tokyo, Japan, ²Tokyo Women's Medical University, Tokyo, Japan, ³Tokyo Wimen's Medical University, Tokyo, Japan, ⁴Department of Urology, Tokyo Women's Medical University, Tokyo, Japan
*Purpose: We examined a positivity of corona virus antibody in kidney transplant recipients who received two-doses BNT162B2 (mRNA) vaccination during the beginning 6 months in…
2022 American Transplant Congress
Abdominal Incision Technique Tailored to Patient’s Age May Reduce the Rate of Surgical Wound Complication After Unilateral Kidney Transplantation- A Preliminary Report
Y. AlSalmay, P. Bachul, B. Juengel, J. Kumar, A. Perez-Guttierez, R. Barth, J. Fung, P. Witkowski
University of Chicago, Chicago, IL
*Purpose: Previously, we compared the risk of abdominal wound complications after lateral rectus incision sheath (LRS) versus traditional Gibson incision in a retrospective analysis of…
2022 American Transplant Congress
Long Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Kidney Transplant Recipients
J. Leventhal¹, J. Galvin², J. Mathew³, L. Gallon³, D. Belshe⁴, M. Gibson⁴, K. Ravindra⁵, M. Horwitz⁶, S. Ildstad⁷
¹Feinberg School of Medicine, Northwestern University, Chicago, IL, ²University of Illinois Chicago, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Comprehensive Transplant Center, Northwestern University, Chicago, IL, ⁵Department of Surgery, Duke University Medical Center, Durham, NC, ⁶Adult Blood and Marrow Transplant Program, Duke University Medical Center, Durham, NC, ⁷Talaris Therapeutics Inc, Louisville, KY
*Purpose: 37 subjects were transplanted in a phase 2 protocol based upon tolerogenic CD8+/TCR-facilitating cells (FCR001) to induce tolerance in recipients of living donor kidney…
2022 American Transplant Congress
Donor-Derived Cell-Free DNA Across the Spectrum of Solid Organ Transplantation
S. R. Potter¹, J. Miles², K. Qu², R. Woodward², S. Dholakia²
¹Baylor Scott & White Health, Temple, TX, ²CareDx, Inc, Brisbane, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a robust and clinically useful analyte initially validated for kidney allograft surveillance. Emerging data support the utility of dd-cfDNA…
2022 American Transplant Congress
Duration of Brain Death Does Not Impact Short Term Outcomes in Kidney Transplantation
A. M. Hawxby¹, R. Ketcham², J. P. Orlowski³, R. A. Squires², C. Hostetler²
¹Organ Recovery, LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK, ²LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK, ³LifeShare Transplant Donors Services, Oklahoma City, OK
*Purpose: In animal models, brain death has been shown to induce renal injury, primarily due to ischemia, inflammation, and alterations in hemodynamics. However, donor management…
2022 American Transplant Congress
Successful Implementation of a Rural Appalachian Kidney Transplant Program; One Year Outcomes
F. Afridi¹, B. Gillis¹, R. Lopez¹, D. Kannabhiran¹, V. Chaudhary¹, M. Thornberg¹, R. Zomak¹, K. Meyer¹, C. Newman¹, L. Biondi²
¹Department of Surgery, West Virginia University, Morgantown, WV, ²Department of Surgery, West Virginia University, Morgantown, WV, WV
*Purpose: Kidney transplantation has become the optimal treatment for end stage renal disease (ESRD), allowing dialysis free survival. Despite widespread availability of transplant programs; rural…
2022 American Transplant Congress
Single Nuclei RNA-Sequencing Identifies Distinct Immune Cell Profile in Kidney Allograft Fibrosis
J. McDaniels¹, A. Shetty¹, C. Kuscu², C. Kuscu², T. Rousselle¹, E. Bardhi¹, C. Drachenberg¹, M. Talwar², J. Eason², T. Muthukumar³, D. Maluf¹, V. Mas¹
¹University of Maryland Baltimore, Baltimore, MD, ²UTHSC, Memphis, TN, ³Weill Cornell Medicine, New York, NY
*Purpose: A major obstacle after kidney transplantation (KT) is chronic allograft dysfunction characterized by interstitial fibrosis and tubular atrophy (IFTA). Despite extensive research, the cellular…
2022 American Transplant Congress
A Novel Non-Invasive Urine Method for Assessment of Kidney Dysfunction
R. Sarwal¹, W. Yazar¹, N. Titzler¹, M. Sarwal², S. Ghosh¹
¹Nephrosant, Brisbane, CA, ²NephroSant, San Francisco, CA
*Purpose: A recent cohort study of 10 869 living kidney donors from ImmPort highlighted that 14.7% have postdonation events unto 40 yrs later, relating to increased…