Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Insulin Secretion and Insulin Resistance Trajectories Over 1 Year After Kidney Transplantation: A Multicenter Prospective Cohort Study
B. Jun Bae, C. Oh
Department of Surgery, Ajou University Medical School, Suwon, Korea, Republic of
*Purpose: We investigated the changing patterns of insulin secretion and resistance and risk factors contributing to the development of post-transplant diabetes mellitus (PTDM) in kidney…
2021 American Transplant Congress
Profound Opportunities Lost: Patients with High Priority for Ideal Donor Kidneys That are Not Placed on the Kidney Transplant Waiting List
J. Schold¹, A. Huml¹, E. Poggio¹, J. Sedor¹, S. Husain², K. L. King², S. Mohan²
¹Cleveland Clinic Foundation, Cleveland, OH, ²Columbia University, New York, NY
*Purpose: The national Kidney Allocation System(KAS) prioritizes patients with high (top 20%) Estimated Post-Transplant Survival (EPTS) with expedited access to high quality deceased donor kidneys.…
2021 American Transplant Congress
Pharmacokinetic Analysis of Direct Acting Antiviral Use on Weight-Adjusted FK506 Trough/dose Ratios in Obese Kidney Transplant Recipients
A. Demirag¹, P. L. Lobo², J. Oberholzer¹, A. Kumar², B. Rawashdeh¹, S. L. Lennon¹, H. N. Guvener Demirag¹, A. Doyle², J. Geystone³, K. L. Brayman¹
¹Transplantation, University of Virginia Medical Center, Charlottesville, VA, ²Transplantation Nephrology, University of Virginia Medical Center, Charlottesville, VA, ³Clinical Pharmacy, University of Virginia Medical Center, Charlottesville, VA
*Purpose: Using hepatitis C viremic (HCV) organs in kidney transplant recipients(KTRs) is very important to decrease the number of patients on the waiting list. Direct…
2021 American Transplant Congress
Early Outcome of Heart-Kidney Transplantation in the Current Heart Allocation System in the United States
S. Rao¹, A. Doyle¹, D. Brennan², S. Constantinescu³
¹University of Virginia, Charlottesville, VA, ²Johns Hopkins Medical Institute, Baltimore, MD, ³Lewis Katz School of Medicine at Temple University, Philadelphia, PA
*Purpose: In the United States, heart allograft allocation is a primary determinant for heart-kidney transplantation (HKT). We analyzed the OPTN dataset and compared the outcomes…
2021 American Transplant Congress
Kidney Transplant Rejection Can Be Diagnosed or Even Predicted by Tracking Donor Reactive T Cell Clones in Post-transplant Samples
Y. Sambandam¹, M. Kandpal¹, J. He¹, X. Huang¹, T. S. Taylor¹, A. A. Shetty², J. M. Mathew¹, J. R. Leventhal¹
¹Surgery-Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine, Nephrology Division, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: To test if kidney transplant (KTx) rejection can be diagnosed by monitoring for donor reactive T-cell (DRTC) clones in post-transplant (post-tx) biopsy and non-invasively…
2021 American Transplant Congress
Obesity is Associated with Greater Gender Disparity in Access to Kidney Transplantation
S. S. Sheikh, B. Orandi, P. MacLennan, H. Qu, R. M. Cannon, D. Anderson, M. Hanaway, S. Mehta, V. Kumar, R. Reed, J. Locke
Surgery, University of Alabama at Birmingham, Birmingham, AL
*Purpose: Obesity and female gender have been associated with decreased access to kidney transplant. We sought to use contemporary data to examine the likelihood of…
2021 American Transplant Congress
High Donor-Derived Cell-Free DNA Levels Predict Development of De Novo HLA Donor-Specific Antibodies After Kidney Transplantation – Data from the ADMIRAL Study
G. Gupta¹, T. Alhamad², V. Bowers³, I. Moinuddin¹, S. Ghosh⁴, J. Zeng⁴, E. Stites⁵, A. Pai⁶, J. S. Bromberg⁷, S. Anand⁸
¹Virginia Commonwealth University, Richmond, VA, ²Washington University in St. Louis, St. Louis, MO, ³Tampa General Hospital, Tampa, FL, ⁴CareDx, Brisbane, CA, ⁵University of Colorado, Aurora, CO, ⁶University of Texas McGovern Medical School, Houston, TX, ⁷University of Maryland School of Medicine, Baltimore, MD, ⁸Intermountain Medical Center, Murray, UT
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) as a marker of injury can serve to quantify subclinical inflammation and molecular injury. As the release of graft genomic…
2021 American Transplant Congress
Cost-Effectiveness Analysis of Short-Duration Anti-Viral Prophylaxis for Hepatitis C Positive Donor Kidney Transplants
I. Yakubu, Y. Zhang, S. Ijioma, N. V. Carroll, J. Patterson, R. Sterling, G. Gupta
Virginia Commonwealth University Health System, Richmond, VA
*Purpose: Trials describing 4-12 week courses of direct-acting anti-viral drugs (DAAs) to treat hepatitis C virus (HCV) transmission from infected donors to uninfected kidney transplant…
2021 American Transplant Congress
High Interest, Low Payoff: Understanding Opportunities for Intervention for Those Exploring but Not Pursuing Paired Kidney Donation
A. D. Waterman¹, E. H. Wood¹, A. Thomas²
¹UCLA David Geffen School of Medicine, Los Angeles, CA, ²Johns Hopkins, Baltimore, MD
*Purpose: In 2016, the National Kidney Registry (NKR) established an online donor screening portal (DASH) to manage and track individuals interested in kidney paired donation…
2021 American Transplant Congress
Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B are Increased in Patients with Kidney Allograft Antibody-mediated Rejection
S. Clotet-Freixas¹, M. Kotlyar², C. M. McEvoy¹, C. Pastrello², S. Rodríguez-Ramírez¹, S. Farkona¹, H. Cardinal³, M. Dieudé³, M. Hébert³, Y. Li¹, O. Famure¹, P. Chen¹, S. Kim¹, E. Chan⁴, I. Jurisica², R. John¹, A. Chruscinski¹, A. Konvalinka¹
¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, ⁴Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada
*Purpose: Antibody-mediated rejection (AMR) causes >50% of late kidney graft losses. Although donor-specific antibodies (DSA) against HLA cause AMR, antibodies against non-HLA antigens are also…