Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Transplant Data Platform – An Augmented Clinical Intelligence Framework
C. Focht, W. Tian, J. Zeng, N. Dzebisashvili, S. Ghosh
CareDx, Brisbane, CA
*Purpose: UNOS, SRTR, USRDS registries are rich in patient baseline data. However, all suffer from data attrition as patients move further out post-transplant or between…
2021 American Transplant Congress
Kidney Transplantation in Times of Covid-19 – Decision Analysis in the Canadian Context
I. Yanev¹, M. Gagnon¹, M. Cheng², S. Paraskevas², D. Kumar³, A. Dragomir⁴, R. Sapir-Pichhadze⁴
¹McGill University, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada, ³University Health Network, Toronto, ON, Canada, ⁴Research Institute of McGill University Health Centre, Montreal, QC, Canada
*Purpose: The coronavirus disease 2019 (COVID-19) pandemic significantly impacted the field of transplantation across Canada. In this study, we outline the implications of COVID-19 related…
2021 American Transplant Congress
Kidney Transplantation in Very Highly-Sensitized Patients with Maastricht Type III Non-heart-Beating Donors
F. Villanego¹, A. Mazuecos¹, L. Vigara¹, V. Lopez², G. Bernal³, A. Rodriguez-Benot⁴, M. de Gracia⁵, P. Castro⁶, A. Alvarez⁶
¹Department of Nephrology, Hospital Puerta del Mar, Cadiz, Spain, ²Department of Nephrology, Hospital Carlos Haya, Malaga, Spain, ³Department of Nephrology, Hospital Virgen del Rocio, Sevilla, Spain, ⁴Department of Nephrology, Hospital Reina Sofia, Cordoba, Spain, ⁵Department of Nephrology, Hospital Virgen de las Nieves, Granada, Spain, ⁶Andalusian Transplant Coordination, Sevilla, Spain
*Purpose: In 2012, a kidney transplant (KT) program for very highly-sensitized (VHS) patients (PRA ≥ 95%) based on virtual crossmatch began in Andalusia (Spanish region).…
2021 American Transplant Congress
Long Term Safety and Efficacy of Tocilizumab (anti-il6r, Tcz) Therapy in the Treatment of Refractory Chronic Antibody Mediated Rejection (cabmr) in 25 Pediatric Renal Transplant Recipients
M. Pearl¹, P. Weng¹, A. Dokras², H. Pizzo³, J. Garrison³, C. Butler¹, J. Q. Zhang¹, K. Lim³, E. Reed¹, I. Kim³, M. Haas³, X. Zhang³, R. Ettenger¹, S. Jordan³, D. Puliyanda³
¹Pediatric Nephrology, UCLA Medical Center, Los Angeles, CA, ²Pediatric Nephrology, UT South Western, Dallas, CA, ³Pediatric Nephrology, Cedars Sinai Medical Center, West Hollywood, CA
*Purpose: Development of de novo donor specific antibodies (DSA) post renal transplantation puts pediatric patients at risk for chronic Antibody Mediated Rejection (cABMR) and allograft…
2021 American Transplant Congress
An HLA Class II Matching Strategy That Predicts De Novo Donor-specific HLA Antibody Formation Using Low Resolution HLA Types
L. Hidalgo¹, I. Martinez Juarez², L. Morales Buenrostro², S. Shojai³, P. Campbell¹
¹University of Wisconsin Madison, Madison, WI, ²Instituto Nacional de Ciencias Medicas Y Nutricion Salvador Zubrian, Mexico City, Mexico, ³Medicine, University of Alberta, Edmonton, AB, Canada
*Purpose: The development of de novo donor-specific HLA antibodies (dnDSA) is predominantly against HLA-Class II antigens and is a function of the degree of HLA-DQ…
2021 American Transplant Congress
Additional Value to Participation in a National Paired Kidney Exchange Program: Exploring Characteristics of Chain End Living Donors and Waitlist Recipients
N. Osbun¹, A. Thomas², M. Cooper³, S. Flechner⁴, D. Segev², J. Veale¹
¹Urology, University of California Los Angeles, Los Angeles, CA, ²Johns Hopkins University, Baltimore, MD, ³Medstar Georgetown Transplant Institute, Washington DC, DC, ⁴Cleveland Clinic, Cleveland, OH
*Purpose: Non-directed kidney donors can initiate living donor chains that end to patients on the deceased donor waitlist. While many studies of paired exchange practices…
2021 American Transplant Congress
Early Stent Removal in Kidney Transplant Recipients – A Quality Improvement Project
V. Rohan, N. Pilch, M. Altiti, S. Nadig, A. Lin, D. DuBay, P. Baliga
Surgery, Medical University of South Carolina, Charleston, SC
*Purpose: Ureteric Stent placement is a is common practice at the time of kidney transplantation to reduce the incidence and severity of Major Urological Complications…
2021 American Transplant Congress
TOLS are Novel Regulatory TLOs with A B Cell Signature
I. Rosales¹, Q. Yuan¹, C. Yang¹, P. Russell¹, J. Madsen¹, A. Alessandrini¹, R. Colvin¹, -. AA and RC²
¹Massachusetts General Hospital, Boston, MA, ²Co-Senior Authors, Boston, MA
*Purpose: Our previous studies suggest that a DBA/2 kidney graft is accepted by a MHC-fully mis-matched C57/BL6 recipient. Accepted renal allografts exhibited lymphoid like structures…
2021 American Transplant Congress
Investigating the HLA Alloimmune Background of the Histological Changes Suggestive of Antibody-mediated Injury in the Absence of Donor-specific Anti-HLA Antibodies
A. Senev, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: The histology of antibody-mediated rejection is observed frequently after kidney transplantation, but a significant percentage of the patients do not have detectable donor-specific HLA…
2021 American Transplant Congress
Multistep Algorithm to Achieve Weight Loss Goal in Advanced Stage Obesity Kidney Transplant Candidates: A Single Center Preliminary Report
A. Shah, J. Galpern, L. Castaldo, P. Touhy, M. Thomas, A. Aaron, M. Fruscione, L. Dageforde, N. Elias
Transplant Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Obesity causes and complicates glomerulonephritis and chronic kidney disease (CKD) leading to end stage renal disease (ESRD). Kidney Transplantation (KT) improves ESRD patients’ survival…