Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Pharmacokinetic Analysis of Direct Acting Antiviral Use on Weight-Adjusted FK506 Trough/dose Ratios in Obese Kidney Transplant Recipients
A. Demirag¹, P. L. Lobo², J. Oberholzer¹, A. Kumar², B. Rawashdeh¹, S. L. Lennon¹, H. N. Guvener Demirag¹, A. Doyle², J. Geystone³, K. L. Brayman¹
¹Transplantation, University of Virginia Medical Center, Charlottesville, VA, ²Transplantation Nephrology, University of Virginia Medical Center, Charlottesville, VA, ³Clinical Pharmacy, University of Virginia Medical Center, Charlottesville, VA
*Purpose: Using hepatitis C viremic (HCV) organs in kidney transplant recipients(KTRs) is very important to decrease the number of patients on the waiting list. Direct…
2021 American Transplant Congress
Early Outcome of Heart-Kidney Transplantation in the Current Heart Allocation System in the United States
S. Rao¹, A. Doyle¹, D. Brennan², S. Constantinescu³
¹University of Virginia, Charlottesville, VA, ²Johns Hopkins Medical Institute, Baltimore, MD, ³Lewis Katz School of Medicine at Temple University, Philadelphia, PA
*Purpose: In the United States, heart allograft allocation is a primary determinant for heart-kidney transplantation (HKT). We analyzed the OPTN dataset and compared the outcomes…
2021 American Transplant Congress
Belatacept Exposure Not Associated With Rejection. Can Doses be Lowered without Compromising Efficacy?
M. McGowan¹, A. Bickenbach¹, B. Miyagawa², A. Christianson¹, T. Mizuno², P. West-Thielke³, J. Leone⁴, E. Woodle¹, D. Kaufman⁵, A. Wiseman⁶, A. Matas⁷, A. Vinks², R. Alloway¹
¹U Cincinnati, Cincinnati, OH, ²Cincinnati Children's Med Center, Cincinnati, OH, ³U Illinois, Chicago, IL, ⁴Tampa Gen, Tampa, FL, ⁵U Wisconsin, Madison, OH, ⁶Centura Transplant, Denver, CO, ⁷U Minnesota, Minneapolis, MN
*Purpose: Phase 1 and 2 belatacept(BELA) pharmacokinetic(PK) studies informed dosing in phase 3 studies. PK data from these studies revealed higher BELA troughs on Day…
2021 American Transplant Congress
Impact of a Latinx Kidney Transplant Clinic
P. Serrano Rodriguez
Abdominal Transplant Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC
*Purpose: To evaluate the impact of a Latinx clinic in our institution. With a growing increase of end stage renal disease (ESRD)in the Latino population…
2021 American Transplant Congress
Novel Mixed Lymphocyte Reaction Monitoring System That Predicts Chronic Antibody- Mediated Rejection in Kidney Transplant Recipients
N. Iwahara¹, K. Hotta¹, T. Tanabe¹, D. Iwami², Y. Takada³, H. Higuchi¹, H. Sasaki³, H. Harada³, N. Shinohara¹
¹Hokkaido Univercity, Sapporo, Japan, ²Jichi Medical University, Shimotsuke, Japan, ³Sapporo City General Hospital, Sapporo, Japan
*Purpose: Chronic active antibody-mediated rejection (CAAMR) induced by de novo donor-specific antibodies (DSA) is the main cause of graft loss in the long-term. Currently, there…
2021 American Transplant Congress
Outcomes of Kidney Transplantation from Hepatitis C Virus (HCV) Infected Donors Stratified by Recipient HCV Serostatus: A Mate Kidney Analysis
K. K. Sureshkumar¹, B. Chopra¹, R. L. McGill²
¹Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA, ²Nephrology, University of Chicago, Chicago, IL
*Purpose: Kidneys from donors infected with hepatitis C virus (HCV) are increasingly used for transplantation into HCV positive (+) recipients historically and into HCV negative…
2021 American Transplant Congress
Prevalence of Hepatitis E Virus Infection in Solid Organ Transplant Recipients: A Systematic Review and Meta-analysis
P. Hansrivijit¹, A. Trongtorsak², B. Boonpheng³, C. Thongprayoon⁴, W. Cheungpasitporn⁴
¹Department of Internal Medicine, UPMC Pinnacle, Harrisburg, PA, ²Department of Internal Medicine, Amita Health Saint Francis Hospital, Evanston, IL, ³Division of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, CA, ⁴Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN
*Purpose: Hepatitis E virus (HEV) infection is an underdiagnosed disease due to the use of serological assays with low sensitivity. Although most patients with HEV…
2021 American Transplant Congress
Iguratimod Prevents Antibody-mediated Rejection by Regulating Germinal Center Formation and Antibody Production
H. Zhang, A. Chandraker, P. Sage, N. Murakami
Transplantation Research Center, Brigham and Women's Hospital, Boston, MA
*Purpose: Antibody-mediated rejection (ABMR) is a major cause of chronic renal allograft failure without effective treatment, and developing a novel therapy is an urgent need.…
2021 American Transplant Congress
Biomarkers of Kidney Injury and Repair in Expanded-Criteria Deceased Donor Kidney Transplant Recipients: A Prospective Study
A. Al Jurdi¹, O. Efe¹, B. Aoyama², M. Lima², H. Silva², I. Schmidt³, S. Waikar³, V. Sabbisetti⁴, L. V. Riella¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²Escola Paulista de Medicina, UNIFESP, São Paulo, Brazil, ³Boston Medical Center, Boston, MA, ⁴Brigham and Women’s Hospital, Boston, MA
*Purpose: Expanded-criteria donor (ECD) kidney transplants are at higher risk of kidney injury. Biomarkers that better predict short and long-term outcomes in ECD kidney transplant…
2021 American Transplant Congress
Does the Timing of Subclinical Acute Rejection After Kidney Transplant Matter?
P. Portocarrero¹, S. Park², K. Guo³, L. Zhao³, J. Friedewald²
¹Nephrology, Northwestern University, Chicago, IL, ²Transplant Nephrology, Northwestern University, Chicago, IL, ³Feinberg School of Medicine, Northwestern University, Chicago, IL
*Purpose: We hypothesized that the timing of subclinical acute rejection (subAR) diagnosed with biopsy, gene expression profile or donor-derived cell-free DNA is associated with poor…