Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Long Term Safety and Efficacy of Tocilizumab (anti-il6r, Tcz) Therapy in the Treatment of Refractory Chronic Antibody Mediated Rejection (cabmr) in 25 Pediatric Renal Transplant Recipients
M. Pearl¹, P. Weng¹, A. Dokras², H. Pizzo³, J. Garrison³, C. Butler¹, J. Q. Zhang¹, K. Lim³, E. Reed¹, I. Kim³, M. Haas³, X. Zhang³, R. Ettenger¹, S. Jordan³, D. Puliyanda³
¹Pediatric Nephrology, UCLA Medical Center, Los Angeles, CA, ²Pediatric Nephrology, UT South Western, Dallas, CA, ³Pediatric Nephrology, Cedars Sinai Medical Center, West Hollywood, CA
*Purpose: Development of de novo donor specific antibodies (DSA) post renal transplantation puts pediatric patients at risk for chronic Antibody Mediated Rejection (cABMR) and allograft…
2021 American Transplant Congress
An HLA Class II Matching Strategy That Predicts De Novo Donor-specific HLA Antibody Formation Using Low Resolution HLA Types
L. Hidalgo¹, I. Martinez Juarez², L. Morales Buenrostro², S. Shojai³, P. Campbell¹
¹University of Wisconsin Madison, Madison, WI, ²Instituto Nacional de Ciencias Medicas Y Nutricion Salvador Zubrian, Mexico City, Mexico, ³Medicine, University of Alberta, Edmonton, AB, Canada
*Purpose: The development of de novo donor-specific HLA antibodies (dnDSA) is predominantly against HLA-Class II antigens and is a function of the degree of HLA-DQ…
2021 American Transplant Congress
Additional Value to Participation in a National Paired Kidney Exchange Program: Exploring Characteristics of Chain End Living Donors and Waitlist Recipients
N. Osbun¹, A. Thomas², M. Cooper³, S. Flechner⁴, D. Segev², J. Veale¹
¹Urology, University of California Los Angeles, Los Angeles, CA, ²Johns Hopkins University, Baltimore, MD, ³Medstar Georgetown Transplant Institute, Washington DC, DC, ⁴Cleveland Clinic, Cleveland, OH
*Purpose: Non-directed kidney donors can initiate living donor chains that end to patients on the deceased donor waitlist. While many studies of paired exchange practices…
2021 American Transplant Congress
Early Stent Removal in Kidney Transplant Recipients – A Quality Improvement Project
V. Rohan, N. Pilch, M. Altiti, S. Nadig, A. Lin, D. DuBay, P. Baliga
Surgery, Medical University of South Carolina, Charleston, SC
*Purpose: Ureteric Stent placement is a is common practice at the time of kidney transplantation to reduce the incidence and severity of Major Urological Complications…
2021 American Transplant Congress
TOLS are Novel Regulatory TLOs with A B Cell Signature
I. Rosales¹, Q. Yuan¹, C. Yang¹, P. Russell¹, J. Madsen¹, A. Alessandrini¹, R. Colvin¹, -. AA and RC²
¹Massachusetts General Hospital, Boston, MA, ²Co-Senior Authors, Boston, MA
*Purpose: Our previous studies suggest that a DBA/2 kidney graft is accepted by a MHC-fully mis-matched C57/BL6 recipient. Accepted renal allografts exhibited lymphoid like structures…
2021 American Transplant Congress
Investigating the HLA Alloimmune Background of the Histological Changes Suggestive of Antibody-mediated Injury in the Absence of Donor-specific Anti-HLA Antibodies
A. Senev, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: The histology of antibody-mediated rejection is observed frequently after kidney transplantation, but a significant percentage of the patients do not have detectable donor-specific HLA…
2021 American Transplant Congress
Multistep Algorithm to Achieve Weight Loss Goal in Advanced Stage Obesity Kidney Transplant Candidates: A Single Center Preliminary Report
A. Shah, J. Galpern, L. Castaldo, P. Touhy, M. Thomas, A. Aaron, M. Fruscione, L. Dageforde, N. Elias
Transplant Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Obesity causes and complicates glomerulonephritis and chronic kidney disease (CKD) leading to end stage renal disease (ESRD). Kidney Transplantation (KT) improves ESRD patients’ survival…
2021 American Transplant Congress
Psychosocial Determinants of Regimen Adherence Among Kidney Transplant Recipients
A. Balakrishnan, S. Bailey, D. Mroczek, M. Serper, D. P. Ladner, M. S. Wolf
Northwestern University, Chicago, IL
*Purpose: There is increasing evidence suggesting a high prevalence of inadequate medication adherence among kidney transplant recipients (KTRs) and its subsequent consequences on health outcomes.…
2021 American Transplant Congress
Creating Efficiency in the Kidney Transplant Listing: Can We Streamline Candidate Ineligibility?
A. Vijay, N. Langford, K. Atiemo, S. Giusti, M. Killackey, H. Jeon, A. S. Paramesh
Tulane Abdominal Transplant Institute, New Orleans, LA
*Purpose: Evaluation of multiple transplant candidate referrals is a resource-intensive process that may delay listing and eventually transplanting appropriate patients. In this study, we sought…
2021 American Transplant Congress
Proteomic Analysis of Extracellular Vesicles Derived From a Potent Donor-specific Regulatory T Cell-enriched Population Demonstrates Multiple Markers of Immune Suppression
B. Schreiber¹, S. Tripathi¹, M. Blaser², T. Pham², S. Kuraoka², S. A. Singh², E. Aikawa², A. Chandraker¹
¹Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, ²Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA
*Purpose: Extracellular vesicles (EVs) are emerging as vital mediators of intercellular communication and immune regulation. Regulatory T cells (Tregs) play an integral role in immune…