Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Psmp is Discriminative for Chronic Active Antibody-Mediated Rejection and Predicts Graft Risk After Kidney Transplantation
Y. Fu, P. Zhan
Tianjin First Central Hospital, Tianjin, China
*Purpose: Chronic active antibody-mediated rejection (c-aABMR) is an intermediate process in the development of chronic antibody-mediated rejection (c-ABMR), a key problem in the long-term failure…
2021 American Transplant Congress
An Early Look at the OPTN Kidney Paired Donation Pilot Program’s New Priority Points Policy
S. E. Booker¹, R. Leishman¹, D. E. Stewart¹, T. Sandholm², J. Dickerson³, M. Pavlakis⁴, V. Casingal⁵
¹United Network for Organ Sharing, Richmond, VA, ²Carnegie Mellon University, Pittsburgh, PA, ³University of Maryland, College Park, MD, ⁴Beth Israel Deaconess Medical Center, Boston, MA, ⁵Carolinas Medical Center, Charlotte, NC
*Purpose: The OPTN implemented new policy on 10/24/19 changing how Kidney Paired Donation Pilot Program (KPDPP) priority points are awarded. The policy is intended to…
2021 American Transplant Congress
Dialysis Staff-Reported Impact of the Early Covid-19 Pandemic on Kidney Transplant Referrals and Evaluations
A. Perez¹, S. Retzloff¹, T. Browne², A. Cruz³, S. Wright³, S. Pastan⁴, R. Patzer¹
¹Department of Surgery, Emory University School of Medicine, Atlanta, GA, ²College of Social Work, University of South Carolina, Columbia, SC, ³IPRO ESRD Network of the South Atlantic, Morrisville, NC, ⁴Department of Medicine, Emory University School of Medicine, Atlanta, GA
*Purpose: COVID-19 has drastically impacted healthcare systems since its declaration as a pandemic in March 2020. Evidence of this impact persists among solid organ transplant…
2021 American Transplant Congress
Characterization of SGLT2 Inhibitor Use After Abdominal Transplant
F. Hailemariam¹, S. Yeager², J. Schulte³, P. Singh¹, A. Yadav¹
¹Transplant Nephrology, Thomas Jefferson University Hospital, Philadelphia, PA, ²Abdominal Transplant Pharmacist, Thomas Jefferson University Hospital, Philadelphia, PA, ³Abdominal Transplant, Clinical Pharmacist, Thomas Jefferson University Hospital, Philadelphia, PA
*Purpose: Post solid organ transplantation, diabetic kidney disease (DKD) can progress due to recurrent pre-transplantation diabetes or the development of post-transplantation diabetes mellitus (PTDM). This…
2021 American Transplant Congress
Engineered Human Glomerular Endothelial Cells to Identify Non-hla Antibodies and Decipher Their Pathogenicity After Kidney Transplantation
B. Lamarthée¹, C. Burger¹, C. Leclaire¹, L. Morin¹, F. Terzi¹, C. Tinel¹, D. Anglicheau²
¹Inserm U1151, Necker-Enfants Malades Institute, PARIS, France, ²Necker Hospital, AP-HP, Department of Nephrology and Kidney Transplantation, PARIS, France
*Purpose: In kidney transplantation recipients (KTRs), donor-specific antibodies directed against Human Leucocyte Antigens (HLA-DSA) are thought to drive antibody-mediated rejection (AMR) and poor transplant outcome.…
2021 American Transplant Congress
The Impact of Covid-19 in Kidney Transplant Recipients: A Systematic Review and Meta-analysis
J. Kumar¹, J. Pyda², I. Reccia³, F. VIrdis⁴, P. Bachul¹, R. Barth¹, Y. Becker¹, J. Fung¹, P. Witkowski¹
¹University of Chicago, Chicago, IL, ²Beth Israel, Boston, MA, ³Imperial College, London, United Kingdom, ⁴Royal London, London, United Kingdom
*Purpose: To determine pooled prevalence of clinical outcomes among hospitalized kidney transplant recipients with COVID-19 through meta-analysis.*Methods: A systematic database search between Dec1, 2019- Dec1,…
2021 American Transplant Congress
Anti-CD8 Immuno-PET for Non-invasive Tracking of Early Graft Rejection in a Non-human Primate Kidney Transplant Model
K. Bruestle¹, R. Tavare², F. Fredriksson¹, E. Duggan¹, F. Huang¹, B. Bhola¹, J. Giurleo², R. Foster², P. Krueger², M. Dobosz², D. Ekanayake-Alper¹, H. Sakai¹, B. Piegari¹, J. Castrillion¹, S. M. Coley¹, O. Harari², A. Mintz¹, D. Ma², A. Griesemer¹
¹Columbia University Medical Center, New York City, NY, ²Regeneron Pharmaceuticals, Inc, New York City, NY
*Purpose: Infiltration of CD8 T cells into solid organ grafts is an early sign of rejection. REGN5054 is a fully human monoclonal antibody that binds…
2021 American Transplant Congress
Belatacept Pharmacokinetic Analysis Comparing Belatacept Early Steroid Withdrawal Trial (BEST) with Benefit and Benefit-ext Trials
A. Bickenbach¹, M. McGowan¹, B. Miyagawa², T. Mizuno², A. Shields³, A. Christianson¹, P. West-Thielke⁴, J. Leone⁵, E. Woodle¹, D. Kaufman⁶, A. Wiseman⁷, A. Matas⁸, A. Vinks²
¹U Cincinnati, Cincinnati, OH, ²Cincinnati Childrens Med Center, Cincinnati, OH, ³Christ Hospital, Cincinnati, OH, ⁴UIC, Chicago, IL, ⁵Tampa Gen, Tampa, FL, ⁶U Wisconsin, Madison, WI, ⁷Centura Transplant, Denver, CO, ⁸U Minnesota, Minneapolis, MN
*Purpose: Belatacept(BELA) pharmacokinetic(PK) studies informed dosing in phase 3 studies where fixed mg/kg dosing compared a less intense(LI) and more intense(MI) regimen. LI was preferred…
2021 American Transplant Congress
Angiotensin II Type-1 Receptor Antibodies are Associated with Inferior Renal Allograft Survival
P. Martin, E. Santos, N. Gunby, M. Willicombe
Renal Department, Imperial College Healthcare NHS Trust, London, United Kingdom
*Purpose: AT1R-antibodies have been implicated in antibody-mediated vascular rejection in the absence of detectable HLA donor specific antibody (DSA), in addition to cardiovascular diseases. Transplant…
2021 American Transplant Congress
MDR-101-MLK-MERCURY Kidney Transplant Tolerance Study Update
D. Kaufman¹, S. Akkina², M. Stegall³, J. Piper⁴, A. O. Gaber⁵, E. Marin⁶, S. Busque⁷, D. Alonso⁸, M. De Vera⁹, A. Shah¹⁰, A. Patel¹¹, K. Chavin¹², M. Laftavi¹³, S. Collette¹⁴, E. Stites¹⁵, M. Mai¹⁶, M. Cooper¹⁷, D. Brennan¹⁸
¹Surgery, UW, Madison, WI, ²Surgery, Loyola, Chicago, IL, ³Surgery, Mayo, Rochester, MN, ⁴Surgery, Inova, Fairfax, VA, ⁵Surgery, Houston Methodist, Houston, TX, ⁶Nephrology, Yale, New Haven, CT, ⁷Surgery, Stanford, San Francisco, CA, ⁸Surgery, Intermountain, Murray, UT, ⁹Surgery, Loma Linda, Loma Linda, CA, ¹⁰Surgery, TJU, Philadelphia, PA, ¹¹Nephrology, St. Barnabas, Livingston, NJ, ¹²Surgery, UHH, Cincinnati, OH, ¹³Surgery, Upstate, Syracuse, NY, ¹⁴Surgery, CIUSSS, Montreal, ON, Canada, ¹⁵Nephrology, UC Denver, Denver, CO, ¹⁶Nephrology, Mayo - FL, Jacksonville, FL, ¹⁷Surgery, Georgetown, Washington, DC, ¹⁸Medeor, San Francisco, CA
*Purpose: We report interim results of the Phase 3 MERCURY tolerance study, which produces mixed chimerism and ultimately generates operational tolerance allowing for the elimination…