Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Who Can be Matched via Kidney Exchange?
D. C. McElfresh¹, M. Curry², S. E. Booker³, D. Stewart³, M. Stuart³, R. Leishman⁴, T. Sandholm⁵, J. Dickerson²
¹Applied Mathematics, University of Maryland, College Park, MD, ²Computer Science, University of Maryland, College Park, MD, ³United Network for Organ Sharing, Seattle, WA, ⁴UNOS, Seattle, WA, ⁵Computer Science, Carnegie Mellon University, Pittsburgh, PA
*Purpose: Valuable time and resources are spent screening medically-compatible patients and donors for kidney exchange. Exchanges with tens or hundreds of patients can have thousands…
2021 American Transplant Congress
Impact of COVID-19 Crisis on Disparities in Living Kidney Donation in the US
J. Wainright, S. Booker, J. Foutz, A. Henderson, R. Goff, L. Cartwright, D. Klassen
Research, UNOS, Richmond, VA
*Purpose: The COVID-19 pandemic resulted in a dramatic decrease in living kidney donation (LKD) in the U.S. This study investigated the effect of the COVID…
2021 American Transplant Congress
Black Disparity in Access to Kidney Transplant Waitlist Worsens in Illinois After New Kidney Allocation System (kas)
S. Park¹, D. Simpson¹, N. Katariya², J. Friedewald³, B. Ho³, D. P. Ladner¹
¹Transplant Outcomes Research Collaborative, Comprehensive Transplant Center, Northwestern University, Chicago, IL, ²Division of Transplant Surgery, Northwestern University, Chicago, IL, ³Transplant Nephrology, Northwestern University, Chicago, IL
*Purpose: We hypothesized racial/ethnic disparities to access the kidney transplant (KT) waitlist (WL) remain after the implementation of the new kidney allocation system (KAS) at…
2021 American Transplant Congress
Integrative Analyses of Circulating Small Rnas and Paired Kidney Graft Transcriptome in Transplant Glomerulopathy
C. Kuscu¹, K. Manjari², M. Akram³, C. Kuscu⁴, A. Wolen,⁴, A. Bajwa⁴, J. Eason⁴, D. G. Maluf⁵, V. Mas⁶, E. Akalin⁷
¹Surgery, James D Eason Transplant Institute, UTHSC, Memphis, TN, ²Department of Systems and Computational Biology, School of Life Sciences, University of Hyderabad,, Hyderabad,, India, ³Center for Biomedical Informatics, University of Tennessee Health Science Center, Memphis, TN, ⁴Surgery, James D Eason Transplant Institute, Memphis, TN, ⁵Surgery, Program in Transplantation, University of Maryland, Baltimore, MD, ⁶Surgery, Division Surgical Science, University of Maryland, Baltimore, MD, ⁷Medicine, Montefiore Medical Center, Abdominal Transplant Program, Albert Einstein College of Medicine,, NYC, NY
*Purpose: Transplant glomerulopathy (TG) develops through multiple mechanisms including donor-specific antibodies, T cells and innate immunity. We investigate the role of circulating small RNAs (sRNAs)…
2021 American Transplant Congress
Growth Differentiation Factor 15 Predictor Value is Superior to Troponin I in the Evaluation of Kidney Transplant Candidates
M. de Cos Gomez¹, M. Garcia Unzueta², A. Benito Hernandez¹, J. Mazon Ruiz¹, M. Perez Arnedo¹, A. Aguilera Fernandez¹, R. Valero San Cecilio¹, J. Ruiz San Millan¹, E. Rodrigo Calabia¹
¹Nephrology, Marques de Valdecilla University Hospital - IDIVAL, Santander, Spain, ²Clinical Analysis, Marques de Valdecilla University Hospital - IDIVAL, Santander, Spain
*Purpose: Pretransplant cardiac troponin I (cTNI) has demonstrated its predictor value of survival after kidney transplant in previous studies. Growth differentiation factor 15 (GDF-15) is…
2021 American Transplant Congress
The Effect of the Affordable Care Act on Insurance Status, Waitlist, and Transplant Outcomes in Liver Transplantation
B. I. Shaw¹, M. L. Samoylova¹, V. Wang², T. Risoli Jr³, S. Peskoe³, K. Caddell³, L. M. McElroy¹
¹Surgery, Duke University, Durham, NC, ²Population Health Sciences, Duke University, Durham, NC, ³Biostatistics, Duke University, Durham, NC
*Purpose: The Affordable Care Act (ACA) intended to expand Medicaid to cover all adults with income below 138% of federal poverty level. We describe the…
2021 American Transplant Congress
Infectious Complications After Belatacept Conversion in Kidney Transplant
J. E. Marvin¹, D. Amenyedor¹, M. M. Azar², K. Belfield¹, V. Do¹, R. Formica³, E. Cohen¹
¹Pharmacy, Yale New Haven Hospital, New Haven, CT, ²Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, ³Section of Nephrology, Yale School of Medicine, New Haven, CT
*Purpose: Tacrolimus (tac), a calcineurin inhibitor, is associated with multiple adverse effects when used for immunosuppression following kidney transplant (KT). Belatacept (bela) is a monoclonal…
2021 American Transplant Congress
Tacrolimus Therapeutic Exposure is Not Consistently Predicted by Target Troughs or CYP3A5 Variants in Stable Renal Transplant Recipients
K. Tornatore¹, K. Attwood², D. Brazeau³, B. Murray⁴
¹Pharmacy Practice, School of Pharmacy; University at Buffalo, Buffalo, NY, ²Biostatistics, School of Public Health; University at Buffalo, Buffalo, NY, ³Pharmacy Practice, School of Pharmacy; Marshall University, Huntington, WV, ⁴Medicine, Erie County Medical Center Corp., Buffalo, NY
*Purpose: Tacrolimus (TAC) immunosuppression requires therapeutic trough monitoring post-transplant due to notable interpatient pharmacokinetic(PK) variability which may be attributed to CYP3A5 polymorphisms. We investigated the…
2021 American Transplant Congress
The Effect of the Different Donor-Derived HLA T-Cell Epitope Targets on the Development of T Cell-Mediated Rejection After Kidney Transplantation
A. Senev, E. Van Loon, M. Emonds, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: Many kidney allografts fail due to rejections caused by the donor and recipient HLA incompatibility. Recent studies have shown that HLA-DR and DQ mismatches…
2021 American Transplant Congress
Disparities in Access to Listing in Rural Populations Post-KAS Implementation
S. H. Nguyen¹, R. R. Redfield², N. Neidlinger¹, D. P. Foley¹, D. B. Kaufman¹, J. T. Adler³
¹Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²Department of Surgery, University of Pennsylvania, Philadelphia, PA, ³Department of Surgery, Brigham and Women’s Hospital, Boston, MA
*Purpose: One major goal of the Kidney Allocation System (KAS) was to improve access to transplantation. The impact of KAS on rural populations has been…