Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Construction of a Waiting Time Predictive Model for Kidney Transplant with Deceased Donor in the State of São Paulo
J. Silva¹, M. Contti¹, M. Valiatti¹, H. Nga¹, G. Santos¹, M. Perosa², G. Ferreira³, L. Modelli de Andrade¹
¹UNESP, Botucatu, Brazil, ²Hospital Leforte, São Paulo, Brazil, ³Santa Casa de Juiz de Fora, Juiz de Fora, Brazil
*Purpose: Chronic kidney disease is an important public health problem and kidney transplant is the therapy of choice when possible. The transplant system in the…
2021 American Transplant Congress
Peripheral Blood Inflammatory Chemokines Uncover Rejection in the Absence of Histological Lesions
E. Van Loon¹, T. Barba², B. Lamarthée¹, A. Senev¹, O. Thaunat², D. Schols³, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Department of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot Hospital Lyon, Lyon, France, ³Laboratory of Virology and Chemotherapy, KU Leuven, Leuven, Belgium
*Purpose: Cytokines and chemokines play a critical role in the pathophysiology of allograft rejection, but the relation of peripheral blood cytokine expression profiles to clinical…
2021 American Transplant Congress
Outcomes of Kidney Transplant Recipients (KTRs) Comparing Brain Dead Donors’ vs Donation After Cardiac Death Stratified by KDPI, Focus on Marginal Kidneys: A UNOS Database Analysis
B. Chopra¹, K. K. Sureshkumar¹, D. Rajasundaram², E. C. Rodrigo³
¹Allegheny Health Network, Pittsburgh, PA, ²UPMC, Pittsburgh, PA, ³University Hospital Marqués de Valdecilla, Santander, Spain
*Purpose: In deceased donor kidney transplantation (DDKT), donation after cardiac death (DCD) is associated with increased cytokine release and renal tubular injury with consequent increase…
2021 American Transplant Congress
The Benefits of Sharing Non-Directed Donors Nationally Through Paired Exchange
J. Verbesey¹, A. G. Thomas², A. D. Waterman³, J. Vucci¹, G. Vranic¹, A. Gilbert¹, S. Ghasemian¹, M. Cooper¹
¹Georgetown University Hospital, Washington, DC, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³UCLA, Los Angeles, CA
*Purpose: Non-directed donors (NDDs) are a valuable resource that can “unlock” incompatible transplants. Recent advances in paired kidney exchange (PKE) suggest that NDDs may facilitate…
2021 American Transplant Congress
Risk Stratification of Kidney Transplant Patients According to the Different Level of HLA-DQ Disparities
A. Senev¹, A. R. Tambur², M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Northwestern University, Chicago, IL
*Purpose: It is becoming clear that de novo donor-specific antibodies (dnDSA) against HLA-DQ are the most prevalent and the leading cause of chronic antibody-mediated rejection…
2021 American Transplant Congress
Donor-Derived Cell-Free DNA Levels Risk-Stratify Polyoma BK Viremia and Associated Clinical Events After Kidney Transplantation – Preliminary Results from ADMIRAL Study
A. Pai¹, L. Bu², J. S. Bromberg³, G. Gupta⁴, I. Moinuddin⁴, T. Alhamad⁵, V. Bowers⁶, S. Ghosh⁷, W. Tian⁷, E. Stites⁸, S. Anand⁹
¹University of Texas McGovern Medical School, Houston, TX, ²University of Minnesota, Minneapolis, MN, ³University of Maryland School of Medicine, Baltimore, MD, ⁴Virginia Commonwealth University, Richmond, VA, ⁵Washington University in St. Louis, St. Louis, MO, ⁶Tampa General Hospital, Tampa, FL, ⁷CareDx, Brisbane, CA, ⁸University of Colorado, Aurora, CO, ⁹Intermountain Medical Center, Murray, UT
*Purpose: The threshold of 10,000 copies for blood Quant BK PCR has been used as a surrogate for BK nephropathy (BKN) in kidney transplant recipients…
2021 American Transplant Congress
Extreme Phenotype Sampling and Next Generation Sequencing to Identify Genetic Variants Associated with Tacrolimus Metabolism in African American Kidney Transplant Recipients
C. R. Dorr¹, B. Guo², B. Wu², J. Abrahante², D. Schladt³, R. Remmel², W. Guan², A. Muthusamy³, G. Onyeaghala³, N. Pankratz², A. Matas², R. Mannon⁴, W. Oetting², P. Jacobson², A. K. Israni³
¹Hennepin Healthcare Research Institute, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN, ³Nephrology, Hennepin Healthcare Research Institute, Minneapolis, MN, ⁴University of Nebraska Medical Center, Omaha, NE
*Purpose: Tacrolimus (TAC) pharmacogenomics studies identified common genetic variants that alter TAC troughs suggesting strategic dosing for specific populations. Common variants and clinical factors explain…
2021 American Transplant Congress
Belatacept and Carfilzomib-based Treatment of Active Antibody-mediated Rejection in a Sensitized Nonhuman Primate Model
J. Kwun¹, R. Schmitz¹, M. Manook¹, Z. Fitch¹, D. Olaso¹, A. Choi¹, J. Yoon¹, Y. Bae¹, J. Lambris², S. Knechtle¹
¹Surgery, Duke University, Durham, NC, ²Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
*Purpose: One third of sensitized, HLA-incompatible transplant recipients experience antibody-mediated rejection (AMR) with limited effective treatment options. We tested a novel treatment strategy for AMR…
2021 American Transplant Congress
Relationship Between %dd-cfDNA, MMDx Molecular Diagnoses, and Donor-specific Antibody in the Trifecta Study
P. F. Halloran¹, L. G. Hildago², J. Reeve¹, Z. Demko³, A. Prewett³, P. Billings³, J. Truong⁴, P. Vander Horn⁴, &. Trifecta Study Group⁵
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Wisconsin, Madison, WI, ³Natera Inc., San Carlos, CA, ⁴One Lambda Inc., West Hills, CA, ⁵., ., AB, Canada
*Purpose: The Trifecta Study is a prospective multicenter investigator-initiated trial to evaluate the relationship between %dd-cfDNA and molecular biopsy findings at the time an indication…
2021 American Transplant Congress
27 Months Follow Up of a Cohort in the Transplant Continuum After Using a New Electronic Medical Record Tool to Document Transplant Option Discussions Among Patients with EGFR <20 Ml/min/1.73m2
A. A. Yishak¹, M. S. Bhatnagar², A. V. Tomimatsu³, R. La Londe⁴, E. Clark⁵, K. B. Rubenstein⁶, S. Vupputuri⁶
¹MAPMG, McLean, VA, ²Kaiser Permanente |, Oakland, CA, ³Kaiser Permanente, Oakland, CA, ⁴Kaiser Permanente, Oakland,, CA, ⁵Kaiser Permanente, Hyattsville, MD, ⁶MAPRI, Rockville, MD
*Purpose: The purpose of this study was to assess: 1) the documentation of transplant option discussions; 2) the number of members listed & transplanted preemptively;…