2021 American Transplant Congress
Infectious Complications After Belatacept Conversion in Kidney Transplant
*Purpose: Tacrolimus (tac), a calcineurin inhibitor, is associated with multiple adverse effects when used for immunosuppression following kidney transplant (KT). Belatacept (bela) is a monoclonal…2021 American Transplant Congress
Tacrolimus Therapeutic Exposure is Not Consistently Predicted by Target Troughs or CYP3A5 Variants in Stable Renal Transplant Recipients
*Purpose: Tacrolimus (TAC) immunosuppression requires therapeutic trough monitoring post-transplant due to notable interpatient pharmacokinetic(PK) variability which may be attributed to CYP3A5 polymorphisms. We investigated the…2021 American Transplant Congress
The Effect of the Different Donor-Derived HLA T-Cell Epitope Targets on the Development of T Cell-Mediated Rejection After Kidney Transplantation
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: Many kidney allografts fail due to rejections caused by the donor and recipient HLA incompatibility. Recent studies have shown that HLA-DR and DQ mismatches…2021 American Transplant Congress
Disparities in Access to Listing in Rural Populations Post-KAS Implementation
*Purpose: One major goal of the Kidney Allocation System (KAS) was to improve access to transplantation. The impact of KAS on rural populations has been…2021 American Transplant Congress
The Trifecta Study: Calibrating Circulating Donor-Derived Cell-Free DNA at the Time of Indication Biopsies Against the Molecular Phenotype of the Biopsy Reveals a Prominent Association with NK Cell Genes
1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2Natera Inc., San Carlos, CA
*Purpose: The international, multicenter, prospective Trifecta study was designed to calibrate dd-cfDNA% measurements in blood at the time of indication biopsy against the molecular characteristics…2021 American Transplant Congress
Use of Donor Blood Expedites HCV Genotyping and Allows Earlier DAA Initiation for Recipients of HCV+ Kidneys
Tranplant Institute, NYU Langone Health, New York, NY
*Purpose: Utilization of HCV viremic donor kidneys for transplant into HCV naïve recipients has become more widespread, yet best practices governing the initiation, timing or…2021 American Transplant Congress
Pre-transplant Lower Urinary Tract Dysfunction in Men is a Risk Factor for Adverse Outcomes Following Renal Transplantation
*Purpose: The expanding age criteria for candidacy for renal transplantation, in conjunction with prolonged waiting time for deceased donor kidneys has created new challenges for…2021 American Transplant Congress
Pathways and Factors That Confer Therapeutic Properties of Adipose Derived Regenerative Cells in Reducing Ischaemia Reperfusion Injury in Kidney Transplantation
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
*Purpose: Studies in our rat model of ischemic reperfusion injury (IRI) demonstrate improved kidney function post injection of non-cultured autologous adipose-derived regenerative cells (ADRC). The…2021 American Transplant Congress
Remote Monitoring Using Mobile Phlebotomy and Donor-derived Cell-free DNA in Kidney Transplant Recipients During the Covid-19 Pandemic
1NYU Langone, New York, NY, 2Medical Science Liason, CareDx, Brisbane, CA
*Purpose: The rapid shift to telemedicine and remote monitoring of kidney transplant recipients (KTRs) during COVID-19 aimed to mitigate exposure risk for this vulnerable population.…2021 American Transplant Congress
GENiE in a Bottle – Renasight Testing in the Kidney Transplant Setting – A Single Center Experience
1Keck Medical Center at USC, Los Angeles, CA, 2Natera, San Carlos, CA
*Purpose: Renasight™(Natera), a recently available genetic test provides analysis on 382 genes associated with adult-onset kidney disease, covering clinical categories (cystic, tubular, glomerular, complement-related, congenital…
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