Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Who Can be Matched via Kidney Exchange?
D. C. McElfresh¹, M. Curry², S. E. Booker³, D. Stewart³, M. Stuart³, R. Leishman⁴, T. Sandholm⁵, J. Dickerson²
¹Applied Mathematics, University of Maryland, College Park, MD, ²Computer Science, University of Maryland, College Park, MD, ³United Network for Organ Sharing, Seattle, WA, ⁴UNOS, Seattle, WA, ⁵Computer Science, Carnegie Mellon University, Pittsburgh, PA
*Purpose: Valuable time and resources are spent screening medically-compatible patients and donors for kidney exchange. Exchanges with tens or hundreds of patients can have thousands…
2021 American Transplant Congress
Impact of COVID-19 Crisis on Disparities in Living Kidney Donation in the US
J. Wainright, S. Booker, J. Foutz, A. Henderson, R. Goff, L. Cartwright, D. Klassen
Research, UNOS, Richmond, VA
*Purpose: The COVID-19 pandemic resulted in a dramatic decrease in living kidney donation (LKD) in the U.S. This study investigated the effect of the COVID…
2021 American Transplant Congress
Black Disparity in Access to Kidney Transplant Waitlist Worsens in Illinois After New Kidney Allocation System (kas)
S. Park¹, D. Simpson¹, N. Katariya², J. Friedewald³, B. Ho³, D. P. Ladner¹
¹Transplant Outcomes Research Collaborative, Comprehensive Transplant Center, Northwestern University, Chicago, IL, ²Division of Transplant Surgery, Northwestern University, Chicago, IL, ³Transplant Nephrology, Northwestern University, Chicago, IL
*Purpose: We hypothesized racial/ethnic disparities to access the kidney transplant (KT) waitlist (WL) remain after the implementation of the new kidney allocation system (KAS) at…
2021 American Transplant Congress
Utility of Follow-up Biopsies After Acute Rejection in Pediatric Kidney Transplantation
S. S. Raza¹, V. Hauptfeld-Dolejsek¹, F. Rosenblum¹, E. C. Mroczek-Musulman², D. R. Kelly², M. Seifert¹
¹Department of Nephrology, UAB School of Medicine, Birmingham, AL, ²Children’s of Alabama, Birmingham, AL
*Purpose: Treatment of acute kidney transplant rejection in children is often guided by creatinine-based estimates of GFR (eGFR) that may lack sensitivity to determine the…
2021 American Transplant Congress
Intensive Blood Pressure Control Preserves Kidney Allograft Function
K. A. Agarwal¹, U. K. Agarwal², G. S. Silva³, K. J. Pollick³, M. Pavlakis¹
¹Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA, ²Biostatistics consultant, Boston, MA, ³Beth Israel Deaconess Medical Center, Boston, MA
*Purpose: Kidney transplant recipients (KTRs) are at higher risk of major adverse cardiovascular events compared to the general population, with HTN being a crucial risk…
2021 American Transplant Congress
Clinical and Molecular Profiling Can Help in Predicting the Response to Alemtuzumab Treatment in Kidney Transplant Recipients with Severe or Glucocorticoid-Resistant Acute Rejection
D. M. Peelen¹, M. van der Zwan¹, M. C. Clahsen-van Groningen², D. A. Mustafa², C. C. Baan¹, D. A. Hesselink¹
¹Internal Medicine - Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands, ²Pathology, Erasmus MC, Rotterdam, Netherlands
*Purpose: Alemtuzumab is an effective drug for the treatment of severe or glucocorticoid-resistant acute kidney allograft rejection (AR), but can also cause severe adverse events.…
2021 American Transplant Congress
Optimal Antimicrobial Duration for Donor Positive Cultures in Kidney Transplant Recipients
J. Ferrante, K. Schnelle, M. Palettas, S. Sarwar, H. Winters, M. Chunduru
Pharmacy, The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Utilization of organs from infected donors carries the risk of transmission of the donor organism to the recipient. While antimicrobials are recommended in recipients…
2021 American Transplant Congress
Non-Invasive Measurement of Transplant Kidney Fibrosis Using Photoacoustic Imaging
E. Hysi¹, X. He¹, A. Krizova¹, M. Ordon¹, K. T. Pace¹, M. Farcas¹, M. C. Kolios², D. A. Yuen¹
¹St. Michael's Hospital, Toronto, ON, Canada, ²Ryerson University, Toronto, ON, Canada
*Purpose: The presence of donor kidney fibrosis adversely impacts transplant outcome. Biopsy remains the only method that can assess fibrosis, despite being subjected to sampling…
2021 American Transplant Congress
Reassessing TCMR in Kidney Transplant Indication Biopsies: Emerging Evidence for Partial Exhaustion in Late TCMR
P. Halloran¹, J. Reeve¹, &. the INTERCOMEX Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: We rederived the MMDx rejection archetypes in an expanded set of 1679 kidney transplant biopsies to add power and potentially define heterogeneity in TCMR.…
2021 American Transplant Congress
Randomized Phase 3 Open-label Study of Maribavir vs Investigator-assigned Therapy for Refractory/resistant Cytomegalovirus Infection in Transplant Recipients: Subgroup Analyses of Efficacy by Organ
R. K. Avery¹, E. A. Blumberg², D. Florescu³, N. Kamar⁴, D. Kumar⁵, J. Wu⁶, A. Sundberg⁶
¹Johns Hopkins Hospital, Baltimore, MD, ²University of Pennsylvania, Philadelphia, PA, ³University of Nebraska School of Medicine, Omaha, NE, ⁴Hôpital de Rangueil, Toulouse, France, ⁵University Health Network, Toronto, ON, Canada, ⁶Shire Human Genetic Therapies, Inc., a Takeda company, Lexington, KY
*Purpose: Therapeutic options for refractory, with/without resistance (R/R), CMV infections are limited. We report organ type subgroup analyses from a large multi-center trial that studied…