Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Engineered Human Glomerular Endothelial Cells to Identify Non-hla Antibodies and Decipher Their Pathogenicity After Kidney Transplantation
B. Lamarthée¹, C. Burger¹, C. Leclaire¹, L. Morin¹, F. Terzi¹, C. Tinel¹, D. Anglicheau²
¹Inserm U1151, Necker-Enfants Malades Institute, PARIS, France, ²Necker Hospital, AP-HP, Department of Nephrology and Kidney Transplantation, PARIS, France
*Purpose: In kidney transplantation recipients (KTRs), donor-specific antibodies directed against Human Leucocyte Antigens (HLA-DSA) are thought to drive antibody-mediated rejection (AMR) and poor transplant outcome.…
2021 American Transplant Congress
The Impact of Covid-19 in Kidney Transplant Recipients: A Systematic Review and Meta-analysis
J. Kumar¹, J. Pyda², I. Reccia³, F. VIrdis⁴, P. Bachul¹, R. Barth¹, Y. Becker¹, J. Fung¹, P. Witkowski¹
¹University of Chicago, Chicago, IL, ²Beth Israel, Boston, MA, ³Imperial College, London, United Kingdom, ⁴Royal London, London, United Kingdom
*Purpose: To determine pooled prevalence of clinical outcomes among hospitalized kidney transplant recipients with COVID-19 through meta-analysis.*Methods: A systematic database search between Dec1, 2019- Dec1,…
2021 American Transplant Congress
Anti-CD8 Immuno-PET for Non-invasive Tracking of Early Graft Rejection in a Non-human Primate Kidney Transplant Model
K. Bruestle¹, R. Tavare², F. Fredriksson¹, E. Duggan¹, F. Huang¹, B. Bhola¹, J. Giurleo², R. Foster², P. Krueger², M. Dobosz², D. Ekanayake-Alper¹, H. Sakai¹, B. Piegari¹, J. Castrillion¹, S. M. Coley¹, O. Harari², A. Mintz¹, D. Ma², A. Griesemer¹
¹Columbia University Medical Center, New York City, NY, ²Regeneron Pharmaceuticals, Inc, New York City, NY
*Purpose: Infiltration of CD8 T cells into solid organ grafts is an early sign of rejection. REGN5054 is a fully human monoclonal antibody that binds…
2021 American Transplant Congress
Belatacept Pharmacokinetic Analysis Comparing Belatacept Early Steroid Withdrawal Trial (BEST) with Benefit and Benefit-ext Trials
A. Bickenbach¹, M. McGowan¹, B. Miyagawa², T. Mizuno², A. Shields³, A. Christianson¹, P. West-Thielke⁴, J. Leone⁵, E. Woodle¹, D. Kaufman⁶, A. Wiseman⁷, A. Matas⁸, A. Vinks²
¹U Cincinnati, Cincinnati, OH, ²Cincinnati Childrens Med Center, Cincinnati, OH, ³Christ Hospital, Cincinnati, OH, ⁴UIC, Chicago, IL, ⁵Tampa Gen, Tampa, FL, ⁶U Wisconsin, Madison, WI, ⁷Centura Transplant, Denver, CO, ⁸U Minnesota, Minneapolis, MN
*Purpose: Belatacept(BELA) pharmacokinetic(PK) studies informed dosing in phase 3 studies where fixed mg/kg dosing compared a less intense(LI) and more intense(MI) regimen. LI was preferred…
2021 American Transplant Congress
Angiotensin II Type-1 Receptor Antibodies are Associated with Inferior Renal Allograft Survival
P. Martin, E. Santos, N. Gunby, M. Willicombe
Renal Department, Imperial College Healthcare NHS Trust, London, United Kingdom
*Purpose: AT1R-antibodies have been implicated in antibody-mediated vascular rejection in the absence of detectable HLA donor specific antibody (DSA), in addition to cardiovascular diseases. Transplant…
2021 American Transplant Congress
MDR-101-MLK-MERCURY Kidney Transplant Tolerance Study Update
D. Kaufman¹, S. Akkina², M. Stegall³, J. Piper⁴, A. O. Gaber⁵, E. Marin⁶, S. Busque⁷, D. Alonso⁸, M. De Vera⁹, A. Shah¹⁰, A. Patel¹¹, K. Chavin¹², M. Laftavi¹³, S. Collette¹⁴, E. Stites¹⁵, M. Mai¹⁶, M. Cooper¹⁷, D. Brennan¹⁸
¹Surgery, UW, Madison, WI, ²Surgery, Loyola, Chicago, IL, ³Surgery, Mayo, Rochester, MN, ⁴Surgery, Inova, Fairfax, VA, ⁵Surgery, Houston Methodist, Houston, TX, ⁶Nephrology, Yale, New Haven, CT, ⁷Surgery, Stanford, San Francisco, CA, ⁸Surgery, Intermountain, Murray, UT, ⁹Surgery, Loma Linda, Loma Linda, CA, ¹⁰Surgery, TJU, Philadelphia, PA, ¹¹Nephrology, St. Barnabas, Livingston, NJ, ¹²Surgery, UHH, Cincinnati, OH, ¹³Surgery, Upstate, Syracuse, NY, ¹⁴Surgery, CIUSSS, Montreal, ON, Canada, ¹⁵Nephrology, UC Denver, Denver, CO, ¹⁶Nephrology, Mayo - FL, Jacksonville, FL, ¹⁷Surgery, Georgetown, Washington, DC, ¹⁸Medeor, San Francisco, CA
*Purpose: We report interim results of the Phase 3 MERCURY tolerance study, which produces mixed chimerism and ultimately generates operational tolerance allowing for the elimination…
2021 American Transplant Congress
Initial Kidney Transplant Evaluations with Telehealth: Is it a Pandemic Only Practice?
A. Govil¹, E. Tims², C. Siemer², J. Harris², C. King², S. Shah¹, C. Thakar¹
¹Univ of Cincinnati, Cincinnati, OH, ²UC Health, Cincinnati, OH
*Purpose: COVID -19 pandemic presented an unprecedented challenge to health care systems. It disrupted the transplant processes including evaluations, especially in rural or other geographically…
2021 American Transplant Congress
Transplant Glomerulopathy in the Absence of Donor-specific HLA Antibodies: Risk Factors, Histopathological Features and Graft Outcome
A. Senev, E. Van Loon, M. Emonds, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: Transplant glomerulopathy (TG) is established as a hallmark of chronic antibody-mediated rejection in kidney transplant patients with donor-specific HLA antibodies (HLA-DSA). The clinical importance…
2021 American Transplant Congress
Outcomes of Short-Duration Anti-Viral Prophylaxis for Hepatitis C Positive Donor Kidney Transplants
G. Gupta, I. Yakubu, P. Kimball, L. Kang, K. Mitchell, M. Shinbashi, D. Kumar, I. Moinuddin, L. Kamal, A. King, C. Bhati, M. Levy, A. Cotterell, A. Sharma, R. Sterling
Virginia Commonwealth University Health System, Richmond, VA
*Purpose: Trials describing 4-12 week courses of direct-acting anti-viral drugs (DAAs) to treat hepatitis C virus (HCV) transmission from infected donors to uninfected kidney transplant…
2021 American Transplant Congress
Compatible Paired Donation in Paired Kidney Exchange: A Look at the Road Not Taken
G. Vranic, A. Gilbert, B. Thomas, S. Ghasemian, M. Cooper, J. Verbesey
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Paired kidney exchange (PKE) offers incompatible donor-recipient pairs increased access to transplant. Compatible pairs are increasingly joining the PKE in an effort to find…