Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Racial/ethnic and Sex Disparities in Renal Transplant Waitlisting Accounting for Pre-Waitlist Mortality
R. Hamoda¹, R. Patzer², M. Saunders¹
¹University of Chicago, Chicago, IL, ²Emory University, Atlanta, GA
*Purpose: The purpose of this study was to assess racial/ethnic and sex differences in access to the renal transplant deceased donor waiting list among incident…
2021 American Transplant Congress
Dynamic Forecasting of Patient-Specific Kidney Transplant Function with a Sequence-to-Sequence Deep-Learning Model
E. Van Loon¹, W. Zhang², A. Van Craenenbroeck¹, B. De Moor², M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²ESAT Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium
*Purpose: Alike other clinical biomarkers, eGFR trajectories are characterized by intra-individual variability, related to biological fluctuations and analytical error. These fluctuations hamper the distinction between…
2021 American Transplant Congress
Predictors of Severe Covid-19 in Kidney Transplant Recipients in the First and Second Waves: Analysis of the Spanish Registry
M. Crespo¹, A. Mazuecos², I. Pérez-Flores³, F. Moreso⁴, A. Andrés⁵, C. Jimenez⁶, M. Molina⁷, C. Canal⁸, L. Sánchez-Cámara⁹, S. Zárraga¹⁰, M. Ruiz Fuentes¹¹, M. Aladrén¹², E. Melilli¹³, V. López¹⁴, E. Sanchez¹⁵, J. Pascual for Spanish Nephro Society Covid-Registry¹
¹Nephrology, Hospital del Mar, Barcelona, Spain, ²Nephrology, Hospital Puerta del Mar, Cadiz, Spain, ³Nephrology, Hospital Clinico San Carlos, Madrid, Spain, ⁴Nephrology, Hospital Valle Hebrón, Barcelona, Spain, ⁵Nephrology, Hospital 12 Octubre, Madrid, Spain, ⁶Nephrology, Hospital La Paz, Madrid, Spain, ⁷Nephrology, Hospital Germans Trias i Pujol, Barcelona, Spain, ⁸Nephrology, Fundacio Puigvert, Barcelona, Spain, ⁹Nephrology, Hospital Gregorio Marañón, Madrid, Spain, ¹⁰Nephrology, Hospital de Cruces, Bilbao, Spain, ¹¹Nephrology, Hospital Virgen de las Nieves, Granada, Spain, ¹²Nephrology, Hospital Miguel Servet, Zaragoza, Spain, ¹³Nephrology and Kidney Transplantation, Hospital de Bellvitge, Barcelona, Spain, ¹⁴Nephrology, Hospital Regional de Málaga, Malaga, Spain, ¹⁵Nephrology, Hospital de Cabueñes, Gijon, Spain
*Purpose: To better know the impact and characteristics of Covid-19 in renal patients, the Spanish Society of Nephrology set up a voluntary registry in March,…
2021 American Transplant Congress
Donor-Recipient BSA Matching is Prognostically Significant in Solitary and En-bloc Kidney Transplantation from Pediatric Circulatory Death Donors
C. J. Little, A. A. Dick, J. D. Perkins, J. D. Reyes
Department of Surgery, University of Washington, Seattle, WA
*Purpose: The purpose of this study was to evaluate the pernicious effects of inadequate functional nephron mass in size disparate donation after cardiac death (DCD)…
2021 American Transplant Congress
Expanding A₂ to B Kidney Transplantation: Safe and Effective Use of Recipients with High Titer Antibodies
A. Gilbert¹, S. Radomski², J. Verbesey¹, J. Vucci¹, M. Cooper¹
¹Medstar Georgetown Transplant Institute, Washington, DC, ²Department of Surgery, Johns Hopkins Medical Center, Baltimore, MD
*Purpose: Minor ABO incompatible (ABOi) transplants from blood group A2 or A2B donors have increased since 2014, but virtually all centers limit recipients to having…
2021 American Transplant Congress
Mapping Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI) in Kidney Transplant Biopsies Reveals Two Classes of Early AKI That Differ in Their Response-to-Wounding
P. Halloran¹, J. Reeve¹, G. Böhmig², O. Viklicky³, M. Myslak⁴, G. Gupta⁵, &. the INTERCOMEX Study Group⁶
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²Medical University of Vienna, Vienna, Austria, ³Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁴Pomeranian Medical University, Szczecin, Poland, ⁵Virginia Commonwealth University, Richmond, VA, ⁶., ., AB, Canada
*Purpose: We recently analyzed injury-induced molecular changes in kidney transplant biopsies using principal component analysis (PCA) (AJT https://doi.org/10.1111/ajt.16374). PC1 reflected all injury, PC2 distinguished early…
2021 American Transplant Congress
High Levels of Donor-Derived Cell-Free DNA Predict EGFR Decline After Kidney Transplantation
T. Alhamad¹, V. Bowers², E. Stites³, S. Anand⁴, J. S. Bromberg⁵, H. Murad¹, G. Gupta⁶, I. Moinuddin⁶, L. Bu⁷, S. Ghosh⁸, J. Zeng⁸, A. Pai⁹
¹Washington University in St. Louis, St. Louis, MO, ²Tampa General Hospital, Tampa, FL, ³University of Colorado, Aurora, CO, ⁴Intermountain Medical Center, Murray, UT, ⁵University of Maryland School of Medicine, Baltimore, MD, ⁶Virginia Commonwealth University, Richmond, VA, ⁷University of Minnesota, Minneapolis, MN, ⁸CareDx, Brisbane, CA, ⁹University of Texas McGovern Medical School, Houston, TX
*Purpose: Persistent, low-grade inflammation is associated with decline in eGFR. Cross-sectional studies have demonstrated a consistent association between circulating inflammatory markers and kidney function. Our…
2021 American Transplant Congress
Immunosuppression Reduction Strategies for Polyoma BK Viremia in Kidney Transplant Patients on Belatacept-Based Immunosuppression
O. Roe¹, E. Meredith¹, A. Reid², A. Basu³
¹Emory University Hospital, Atlanta, GA, ²University of California San Francisco Medical Center, San Francisco, CA, ³Emory Transplant Center, Atlanta, GA
*Purpose: The mainstay of treatment for BK infection is immunosuppression (IS) reduction, however limited literature provides guidance for treatment of patients with a belatacept-based IS…
2021 American Transplant Congress
Single Cell Rna-Sequencing of Urinary Cells and Defining the Immune Landscape of Rejection in Human Kidney Allografts
T. Muthukumar¹, H. Yang¹, A. Belkadi², G. Thareja², C. Li¹, C. Snopkowski¹, K. Chen¹, T. Salinas¹, M. Lubetzky¹, J. Lee¹, D. Dadhania¹, K. Suhre², M. Suthanthiran¹
¹Nephrology, NY Presbyterian- Weill Cornell Medical College, New York, NY, ²Physiology and Biophysics, Weill Cornell Medicine-Qatar, Doha, Qatar
*Purpose: Transcriptome-based clustering of urinary cells in kidney transplant recipients may help identify cell-type specific injury and develop cell-type specific biomarkers for the noninvasive assessment…
2021 American Transplant Congress
Successful Long-Term TMA- and Rejection-Free Survival of a Kidney Xenograft With Triple Xenoantigen Knockout Plus Insertion of Multiple Human Transgenes
T. Hirose¹, D. Ma¹, G. Lassiter¹, H. Sasaki¹, I. Rosales², T. Coe¹, C. Rickert¹, R. Matheson¹, R. Colvin², W. Qin³, Y. Kan³, J. Layer³, K. Stiede³, K. Hall³, M. Youd³, W. Westlin³, M. Curtis³, J. F. Markmann¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA, ³eGenesis Inc, Cambridge, MA
*Purpose: Pigs with deletion of 3 carbohydrate xenoantigens (triple knock-out, TKO) are expected to be optimal donors for human xenotransplantation. However, anti-porcine natural antibodies of…