Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Belatacept Conversion in Proteinuric Renal Transplant Recipients: An Interventional Multi-Center Trial
O. Efe¹, A. Al Jurdi¹, D. Wojciechowski², K. Safa¹, H. Gilligan¹, A. Chandraker³, J. Azzi³, A. Weins³, L. V. Riella¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²UT Southwestern Medical Center, Dallas, TX, ³Brigham and Women’s Hospital, Boston, MA
*Purpose: Proteinuria develops in about 30% of kidney transplant recipients and is a strong predictor of graft loss. ACEis/ARBs can reduce proteinuria but are frequently…
2021 American Transplant Congress
I Would Do Whatever It Took”: Understanding the Motivation, Education and Experiences of Kidney Paired Donation Participants
R. Pines¹, Y. A. Iraheta², L. Ambriz², K. A. Dahmani², E. H. Wood², M. Cooper³, A. D. Waterman²
¹Santa Barbara Cottage Hospital, Santa Barbara, CA, ²UCLA David Geffen School of Medicine, Los Angeles, CA, ³Medstar Georgetown Transplant Institute, Washington, DC
*Purpose: To improve kidney paired donation (KPD) educational programs, we conducted semi-structured interviews to understand motivations of past recipients and donors to participate in KPD,…
2021 American Transplant Congress
Equity in Access to Kidney Transplants by Race/ethnicity in the Covid-19 Era
D. Stewart¹, A. Robinson², K. Bradbrook², A. Wilk², D. Klassen³
¹United Network for Organ Sharing, Richmond, VA, ²Research, United Network for Organ Sharing, Richmond, VA, ³Chief Medical Officer, United Network for Organ Sharing, Richmond, VA
*Purpose: The direct impact of the COVID-19 pandemic on minority populations has been well documented, and it is conceivable that disparities in access to kidney…
2021 American Transplant Congress
Attitudes Regarding Transplantation During the Pandemic: Give Me My Kidney Now!
T. Menser¹, M. Hobeika², A. Gaber², H. Ibrahim²
¹Houston Methodist Research Institute, Houston, TX, ²Houston Methodist Hospital, Houston, TX
*Purpose: The transplant community faces ongoing challenges regarding the conduct of organ transplantation during the COVID-19 pandemic, and patient treatment preferences during the pandemic require…
2021 American Transplant Congress
Integrative Analyses of Circulating Small Rnas and Paired Kidney Graft Transcriptome in Transplant Glomerulopathy
C. Kuscu¹, K. Manjari², M. Akram³, C. Kuscu⁴, A. Wolen,⁴, A. Bajwa⁴, J. Eason⁴, D. G. Maluf⁵, V. Mas⁶, E. Akalin⁷
¹Surgery, James D Eason Transplant Institute, UTHSC, Memphis, TN, ²Department of Systems and Computational Biology, School of Life Sciences, University of Hyderabad,, Hyderabad,, India, ³Center for Biomedical Informatics, University of Tennessee Health Science Center, Memphis, TN, ⁴Surgery, James D Eason Transplant Institute, Memphis, TN, ⁵Surgery, Program in Transplantation, University of Maryland, Baltimore, MD, ⁶Surgery, Division Surgical Science, University of Maryland, Baltimore, MD, ⁷Medicine, Montefiore Medical Center, Abdominal Transplant Program, Albert Einstein College of Medicine,, NYC, NY
*Purpose: Transplant glomerulopathy (TG) develops through multiple mechanisms including donor-specific antibodies, T cells and innate immunity. We investigate the role of circulating small RNAs (sRNAs)…
2021 American Transplant Congress
Growth Differentiation Factor 15 Predictor Value is Superior to Troponin I in the Evaluation of Kidney Transplant Candidates
M. de Cos Gomez¹, M. Garcia Unzueta², A. Benito Hernandez¹, J. Mazon Ruiz¹, M. Perez Arnedo¹, A. Aguilera Fernandez¹, R. Valero San Cecilio¹, J. Ruiz San Millan¹, E. Rodrigo Calabia¹
¹Nephrology, Marques de Valdecilla University Hospital - IDIVAL, Santander, Spain, ²Clinical Analysis, Marques de Valdecilla University Hospital - IDIVAL, Santander, Spain
*Purpose: Pretransplant cardiac troponin I (cTNI) has demonstrated its predictor value of survival after kidney transplant in previous studies. Growth differentiation factor 15 (GDF-15) is…
2021 American Transplant Congress
The Effect of the Affordable Care Act on Insurance Status, Waitlist, and Transplant Outcomes in Liver Transplantation
B. I. Shaw¹, M. L. Samoylova¹, V. Wang², T. Risoli Jr³, S. Peskoe³, K. Caddell³, L. M. McElroy¹
¹Surgery, Duke University, Durham, NC, ²Population Health Sciences, Duke University, Durham, NC, ³Biostatistics, Duke University, Durham, NC
*Purpose: The Affordable Care Act (ACA) intended to expand Medicaid to cover all adults with income below 138% of federal poverty level. We describe the…
2021 American Transplant Congress
Infectious Complications After Belatacept Conversion in Kidney Transplant
J. E. Marvin¹, D. Amenyedor¹, M. M. Azar², K. Belfield¹, V. Do¹, R. Formica³, E. Cohen¹
¹Pharmacy, Yale New Haven Hospital, New Haven, CT, ²Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, ³Section of Nephrology, Yale School of Medicine, New Haven, CT
*Purpose: Tacrolimus (tac), a calcineurin inhibitor, is associated with multiple adverse effects when used for immunosuppression following kidney transplant (KT). Belatacept (bela) is a monoclonal…
2021 American Transplant Congress
Tacrolimus Therapeutic Exposure is Not Consistently Predicted by Target Troughs or CYP3A5 Variants in Stable Renal Transplant Recipients
K. Tornatore¹, K. Attwood², D. Brazeau³, B. Murray⁴
¹Pharmacy Practice, School of Pharmacy; University at Buffalo, Buffalo, NY, ²Biostatistics, School of Public Health; University at Buffalo, Buffalo, NY, ³Pharmacy Practice, School of Pharmacy; Marshall University, Huntington, WV, ⁴Medicine, Erie County Medical Center Corp., Buffalo, NY
*Purpose: Tacrolimus (TAC) immunosuppression requires therapeutic trough monitoring post-transplant due to notable interpatient pharmacokinetic(PK) variability which may be attributed to CYP3A5 polymorphisms. We investigated the…
2021 American Transplant Congress
The Effect of the Different Donor-Derived HLA T-Cell Epitope Targets on the Development of T Cell-Mediated Rejection After Kidney Transplantation
A. Senev, E. Van Loon, M. Emonds, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: Many kidney allografts fail due to rejections caused by the donor and recipient HLA incompatibility. Recent studies have shown that HLA-DR and DQ mismatches…