Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Detection of Rejection in Kidney Transplant Patients Using an Algorithm That Combines Donor Fraction and Absolute Donor-derived Cell-free DNA
S. Bunnapradist¹, E. Ahmed², M. Maninder², Z. P. Demko², P. R. Billings², H. Tabriziani², P. Gauthier³
¹David Geffen Sch of Med @ UCLA, Los Angeles, CA, ²Natera, Inc., San Carlos, CA, ³Natera, Inc., Los Angeles, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) in the plasma of renal allograft patients is a clinically validated biomarker for allograft injury and rejection. Several dd-cfDNA assays…
2021 American Transplant Congress
Characterization of Chronic Renal Allograft Dysfunction at Single Cell Resolution
C. Kuscu¹, C. Kuscu², A. Shetty³, M. Talwar⁴, J. Eason², D. G. Maluf⁵, V. Mas⁶
¹Surgery, James D Eason Transplant Institute, UTHSC, Memphis, TN, ²Surgery, James D Eason Transplant Institute, Memphis, TN, ³Institute for Genome Sciences, School of Medicine, University of Maryland, Baltimore, MD, ⁴Nephrology, James D Eason Transplant Institute, Memphis, TN, ⁵Surgery, Program in Transplantation - University of Maryland, Baltimore, MD, ⁶Surgery, Division of Surgical Science - University of Maryland, Baltimore, MD
*Purpose: Chronic allograft dysfunction (CAD) is one of the major complications after kidney transplantation. Hereby, we aim to assess the molecular and cellular mechanism of…
2021 American Transplant Congress
Regional Impact of Covid-19 on Kidney Transplant in the Southeast
C. Jay¹, B. Sharda¹, R. Helmick², R. Forbes³, V. Casingal⁴, R. Stratta¹
¹Wake Forest Baptist Health, Division of Abdominal Organ Transplantation, Winston-Salem, NC, ²University of Tennessee Health Science Center, James Eason Transplant Institute, Memphis, TN, ³Vanderbilt University Medical Center, Division of Kidney and Pancreas Transplantation, Nashville, TN, ⁴Atrium Health, Division of Transplant Surgery, Charlotte, NC
*Purpose: Despite categorization of kidney transplantation as Tier 3b with guidelines against postponing, the impact of the COVID-19 pandemic has been profound but geographically diverse.…
2021 American Transplant Congress
Development of De-novo Malignancies After Kidney and/or Pancreas Transplantation in Diabetic Patients
A. Gruessner, S. Saggi, J. Renz, R. Gruessner
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Transplantation of a kidney (KTA), pancreas (PTA), or a simultaneous pancreas-kidney (SPK) in a patient with end-stage organ failure is a lifesaving treatment. Patient…
2021 American Transplant Congress
SARS-CoV-2 Antibody Response After Induction Therapy in Kidney Transplant Recipients
M. Lubetzky¹, S. Sultan², Z. Zhao³, M. Cushing³, Z. Kapur¹, S. Albakry¹, N. Hauser¹, J. Marku-Podvorica¹, R. Craig-Schapiro², J. Lee¹, T. Salinas¹, M. Aull², S. Kapur², M. Suthanthiran¹, D. Dadhania¹
¹Nephrology, Weill Cornell-NYPresbyterian, New York, NY, ²Transplant Surgery, Weill Cornell-NYPresbyterian, New York, NY, ³Pathology, Weill Cornell-NYPresbyterian, New York, NY
*Purpose: SARS-CoV-2 antibody prevalence in kidney transplant recipients is beginning to be reported, although little is known about the humoral immune response in the immediate…
2021 American Transplant Congress
Characterizing the Early Impact of the Kidney Accelerated Placement Project on Hard-to-place Kidneys
J. D. Motter, A. Kernodle, M. Levan, D. Segev, J. Garonzik-Wang, A. Massie
Johns Hopkins University, Baltimore, MD
*Purpose: In 2019, the OPTN implemented the Kidney Accelerated Placement Project (KAPP) in an effort to increase the utilization of kidneys with a high Kidney…
2021 American Transplant Congress
How Long is the Wait Worthwhile: Cost-Effectiveness of Accepting a Kidney from a Donor with Apolipoprotein L1 High-Risk Genotype
K. Lentine¹, D. Brennan², M. Wang³, M. Schnitzler⁴, H. Xiao⁴, D. Axelrod⁵, J. Snyder⁶, K. Lentine⁴
¹Saint Louis University, St. Louis, MO, ²Johns Hopkins, Baltimore, MD, ³Washington Univ, Saint Louis, MO, ⁴Saint Louis Univ, Saint Louis, MO, ⁵Univ of Iowa, Iowa City, IA, ⁶SRTR, Minneapolis, MN
*Purpose: The Apolipoprotein L1 (APOL1) Long-Term Outcomes (APOLLO) study is underway to define the impact of kidney donor renal risk variants (RRVs) on the survival…
2021 American Transplant Congress
The Effect of Delayed Graft Function on Early versus Late Mortality Following Kidney Transplantation
W. Irish¹, Y. Fu², D. B. Leeser¹, K. V. Ravindra³, C. Haisch¹, J. Tuttle¹
¹Surgery, East Carolina University, Greenville, NC, ²Mathematics, East Carolina University, Greenville, NC, ³Surgery, Duke University, Durham, NC
*Purpose: Delayed graft function (DGF) is associated with increased risk of long-term graft survival but it’s impact on patient survival has not been studied. Using…
2021 American Transplant Congress
Assessment of Donor-Derived Cell-Free DNA Performance Characteristics Across the Spectrum of TCMR and ABMR After Kidney Transplant
L. Bu¹, S. Anand², A. Pai³, J. S. Bromberg⁴, T. Alhamad⁵, V. Bowers⁶, I. Moinuddin⁷, S. Ghosh⁸, W. Tian⁸, E. Stites⁹, G. Gupta⁷
¹University of Minnesota, Minneapolis, MN, ²Intermountain Medical Center, Murray, UT, ³University of Texas McGovern Medical School, Houston, TX, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Washington University in St. Louis, St. Louis, MO, ⁶Tampa General Hospital, Tampa, FL, ⁷Virginia Commonwealth University, Richmond, VA, ⁸CareDx, Brisbane, CA, ⁹University of Colorado, Aurora, CO
*Purpose: Different donor-derived cell-free DNA (dd-cfDNA) thresholds have been reported in association with varying TCMR, ABMR and “Borderline” diagnoses. Interpretation of dd-cfDNA levels spanning active…
2021 American Transplant Congress
Conversion to Belatacept Based Immunosuppression Regimen in Kidney Transplant Patients: Lessons Learned
R. Saidi, N. Huang, C. Yang, I. Movileanu, K. Ecal, A. Senay, O. Pankewycz, R. Dvorai, R. Shahbazov, M. Laftavi
SUNY Upstate, Syracuse, NY
*Purpose: The costimulatory inhibitor, belatacept (Bela) has been shown to be an effective alternative in several clinical situations including calcineurin toxicity, de novo alloantibody formation…