2022 American Transplant Congress
Faster B Cell Rebound is Observed Following Xenotransplantation Compared to Allotransplantation in a Highly Sensitized Nonhuman Primate Kidney Transplantation Model
Surgery, Duke Transplant Center, Durham, NC
*Purpose: Xenotransplantation outcomes have been greatly improved due to the advent of genetically engineered pigs and agents targeting the CD40-CD40L signaling pathway. However, studies have…2022 American Transplant Congress
Validation of Trugraf Gene Expression Profile in a Multicenter Cohort (TOGETHER Study)
*Purpose: The purpose of this study was to validate the performance characteristics of TruGraf GEP in a real-world population.*Methods: This was a multicenter observational analysis…2022 American Transplant Congress
Impact of Early Calcineurin-Inhibitor Conversion to Belatacept on Renal Allograft Function in a Steroid-Free Maintenance Regimen: Results from a Randomized Controlled Study
*Purpose: Belatacept (Bela) was developed to minimize nephrotoxicity and cardiovascular risk associated with Calcineurin inhibitors (CNIs). Early steroid withdrawal (ESW) and simultaneous CNI avoidance (CNIA)…2022 American Transplant Congress
Impact of End-of-Chain Kidney Allocation on Access to Kidney Transplantation of Minority Patients: Implications for Reducing Disparities
*Purpose: Disparities in access to kidney transplantation (KT) among non-White patients is well-known, especially as it relates to living donor kidney transplantation (LDKT). We investigated…2022 American Transplant Congress
Trends in Donor Derived Cell Free DNA Before and After Cellular and Antibody Mediated Rejection
1Northwestern University, Chicago, IL, 2Transplant nephrology, Northwestern University, Chicago, IL
*Purpose: The TRAC dd-cfDNA test was developed to detect acute kidney transplant rejection but can also detect subclinical rejection with improved performance in antibody-mediated rejection…2022 American Transplant Congress
A Three-gene Peripheral Blood Potential Diagnosis Signature Associated With Autophagy For Antibody-mediated Rejection In Renal Transplantation
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
*Purpose: Antibody-mediated rejection (AMR) is emerging as a major cause of graft loss in renal transplantation. Nowadays, non-invasive diagnosis of AMR with high accuracy is…2022 American Transplant Congress
Pegloticase Use in Renal Transplant Recipients with Gout: Findings from an Insurance Claims Database Study
1Iowa Kidney Physicians, Des Moines, IA, 2Horizon Therapeutics plc, Deerfield, IL
*Purpose: Kidney transplant (KT) recipients have high gout incidence due to reduced eGFR and medication use associated with hyperuricemia.1 Oral urate-lowering therapies in KT patients…2022 American Transplant Congress
The Impact of Maintenance Immunosuppressive Regimen on COVID-19 Outcomes Among Kidney Transplant Patients
*Purpose: Compared to azathioprine (AZA), mycophenolate (MPA) is implicated in an increased risk of several viral infections. Contrariwise, mTOR inhibitors (mTORi) are protective. Therefore, the…2022 American Transplant Congress
Time-Dependent Blood Eosinophilia Count Increases the Risk of Kidney Allograft Rejection
*Purpose: There is growing evidence that type 2 immune effectors (immunoglobulin E, eosinophils, mast cells/basophils) play a role in autoimmune disorders and solid organ transplantation.…2022 American Transplant Congress
Donor Disposition AI Model to Predict Transplant for Recovered Deceased Donor Kidneys
1MST, Rolla, MO, 2SLU, Saint Louis, MO
*Purpose: Current practice for accelerated kidney placements rely heavily on the Kidney Donor Profile Index (KDPI) to determine if recovered deceased-donor (DD) kidneys are hard-to-place.…
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