Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Evs from Patients with Amr Induce Tubular Senescence and Endmt Through Horizontal Transfer of Mirnas
R. Franzin¹, A. Stasi¹, F. Sallustio¹, S. Bruno², G. Merlotti³, M. Quaglia³, G. Grandaliano⁴, P. Pontrelli¹, J. Thurman⁵, G. Camussi², G. Stallone⁶, V. Cantaluppi³, L. Gesualdo¹, G. Castellano⁷
¹DETO, University of Bari, Bari, Italy, ²University of Turin, Turin, Italy, ³University of Piemonte Orientale, Novara, Italy, ⁴Università Cattolica Sacro Cuore, Rome, Italy, ⁵University of Colorado School of Medicine, Aurora, CO, ⁶University of Foggia, Foggia, Italy, ⁷University of Milan, Milan, Italy
*Purpose: Extracellular vesicles (EV) are emerging mediators in several diseases; however, their role in antibody-mediated allograft rejection (AMR) has been poorly investigated.*Methods: Plasma EVs from…
2022 American Transplant Congress
Deceased Donor Vein Extension Grafts for Right Living-Donor Kidney Transplantation
A. Meinders, S. G. Yi, M. Hobeika, R. McMillan, H. Podder, A. Gaber, R. J. Knight
Department of Surgery, Houston Methodist Hospital, Houston, TX
*Purpose: In an effort to maximize living donor kidney utilization, we describe the use of deceased donor vein extension grafts for right sided living donor…
2022 American Transplant Congress
Posoleucel as Preemptive Therapy for BKV Infection in Kidney Transplant Recipients: Safety and Tolerability in a Phase 2 Trial
R. K. Wali¹, M. Singh², D. Wojciechowski³, M. J. Ansari⁴, B. Lonze⁵, V. Nair⁶, A. Sharma⁷, S. Knechtle⁸, F. Cardarelli⁹, A. Chandraker¹⁰
¹Inova Transplant Center, Falls Church, VA, ²U. of Pittsburg Medical Center, Harrisburg, PA, ³UT Southwestern Medical Center, Dallas, TX, ⁴Northwestern U. Feinberg School of Medicine, Chicago, IL, ⁵NYU Langone Transplant Institute, New York, NY, ⁶Northwell Health, Manhasset, NY, ⁷U. of Pittsburgh Medical Center, Pittsburgh, PA, ⁸Duke U. School of Medicine, Durham, NC, ⁹AlloVir, Cambridge, MA, ¹⁰Brigham & Women's Hospital, Boston, MA
*Purpose: Kidney transplant (KT) recipients with BK viremia are at risk for BK virus (BKV) nephropathy and graft loss. There are no approved therapies for…
2022 American Transplant Congress
Intraoperative Kinetics of Pro-Inflammatory Markers and Delayed-Graft Function During Kidney Transplantation
P. A. Wadsworth, H. L. Stevenson, M. L. Kueht
University of Texas Medical Branch, Galveston, TX
*Purpose: Detailed molecular changes associated with allograft reperfusion have been poorly defined and current methods of predicting delayed graft function (DGF) after kidney transplantation are…
2022 American Transplant Congress
Performance of Updated Estimated Glomerular Filtration Rate Equations in Black Living Kidney Donor Candidates
J. Augustine, A. Liaqat, S. Arrigain, J. Schold, E. Poggio
Cleveland Clinic, Cleveland, OH
*Purpose: New estimated glomerular filtration rate (eGFR) equations using serum creatinine (Cr) and/or cystatin C (CysC) have been derived to eliminate adjustment by perceived Black…
2022 American Transplant Congress
Conversion of Tacrolimus Immediate Release to LCP Tacrolimus in Obese Kidney Transplant Recipients
J. Newman, N. Patel, S. Patel, T. Sprague, E. Andrade, N. Rao, F. Bartlett, D. DuBay, V. Rohan, M. Casey, D. Taber
MUSC, Charleston, SC
*Purpose: Data describing the safety, efficacy and conversion ratio of tacrolimus immediate release (IR) to LCP-tacrolimus (LCP) in obese patients (BMI > 30) is lacking.…
2022 American Transplant Congress
Tracking of Donor Reactive T Cell Clones Can Be Used to Diagnose or Even Predict Kidney Transplant Rejection
J. M. Mathew¹, Y. Sambandam¹, M. Kandpal¹, J. He¹, G. Perottino¹, B. Banbury², P. Fields², L. Gallon¹, J. R. Leventhal¹
¹Northwestern University, Chicago, IL, ²Adaptive Biotechnologies, Seattle, WA
*Purpose: Transplant (Tx) rejection currently requires an invasive biopsy for diagnosis. We have tested if serial quantitation of donor reactive T cell clones (DRTC) can…
2022 American Transplant Congress
Organ Tracking Combined with Real-Time Communication to Reduce Organ Shipment Delays and Cit: The First Report of a Comprehensive, Scalable System for Organ Tracking and Communication in the United States
A. Melia¹, S. Pankow¹, C. Paydenkar¹, P. Summers¹, J. Scalea²
¹MediGO, Inc., Baltimore, MD, ²Surgery, University of Maryland, Baltimore, MD
*Purpose: Recent organ allocation strategies have elevated the complexity of organ shipment, increasing the organ travel time and distance. Despite these changes, logistics, time, and…
2022 American Transplant Congress
Vitamin D Status and Sars-cov-2 Infection in a Cohort of Renal Transplanted Patients
A. Regalia, C. M. Alfieri, M. Campise, D. Cresseri, M. Gandolfo, P. Messa, G. Castellano
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico Milano, Milano, Italy
*Purpose: Immunomodulatory and anti-inflammatory properties have been hypothesized for native vitamin D (nVD). Very little is reported about nVD and risk of Sars-CoV-2 infection (COV)…
2022 American Transplant Congress
Safety and Immunogenicity of BNT-162b2 versus Chadox1 Vaccine in Solid Organ Transplant Recipients: Prospective Study
A. Ajlan¹, T. Ali², H. Aleid², K. Almeshari², M. Alkaff³, S. Althuwaidi⁴, L. Fajji², A. Alali⁵, D. Halabi⁶, A. Ullah⁷, K. H. Marquez⁸, B. Elmikkaoui⁹, A. Alrajhi¹⁰, A. Zidan¹¹, E. Albogumi.¹², K. Bzeizi¹³, R. Almaghrabi¹⁴, E. DeVol¹⁵, M. Al-Awwami,¹⁶, S. Alghamdi¹³, P. Broering²
¹Pharmaceutical Care Division - Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Centre (KFSHRC), Riaydh, Saudi Arabia, ²Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ³Medical Laboratory, KFSHRC, Riaydh, Saudi Arabia, ⁴Medical Microbiology, KFSHRC, Riaydh, Saudi Arabia, ⁵Transplant Coordination Team - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ⁶Transplant Coordination Team - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ⁷Kidney & Pancreas Health Centre, KFSHRC, Riaydh, Saudi Arabia, ⁸Analytics Data Centre - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ⁹Data Management - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ¹⁰Infectious Diseases - Medicine Department, KFSHRC, Riaydh, Saudi Arabia, ¹¹Abdominal Transplant & Hepatobiliary Surgery Centre, KFSHRC, Riaydh, Saudi Arabia, ¹²Data Management. - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ¹³Liver & Small Bowel Health Centre, KFSHRC, Riaydh, Saudi Arabia, ¹⁴Infectious Diseases - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ¹⁵Biostatistics, Epidemiology &Scientific Computing, KFSHRC, Riaydh, Saudi Arabia, ¹⁶Histocompatibility and Immunogenetics Laboratory Kidney & Pa - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia
*Purpose: Data showed seroconversion after different SARS-CoV-2 vaccination platforms might yield diminished response in transplant recipients. However, it is unknown whether different vaccination platforms could…