Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Role of CD8⁺T Cells Exhaustion in Long Term Spontaneous Acceptance of Mouse Kidney Allograft
J. Ge¹, E. Szuter¹, T. Yokose¹, I. Rosales², A. Cuenca³, P. Russell¹, J. Madsen¹, R. Colvin², A. Alessandrini¹
¹Center of Transplant Science, Massachusetts General Hospital, Boston, MA, ²Department of Pathology, Massachusetts General Hospital, Boston, MA, ³Department of Surgery, Boston Children's Hospital, Boston, MA
*Purpose: CD8+ T cells exhaustion has been shown to promote chronic viral infection and tumor development, resulting from long term exposure to foreign antigen. We…
2022 American Transplant Congress
Poor Outcomes in Patients with Transplant Glomerulopathy Independent of Banff Categorization or Therapeutic Interventions
K. Wu¹, D. Schmidt¹, C. Lopez del Moral¹, Q. Zhang¹, F. Halleck¹, M. G. Naik¹, N. Lachmann², B. Rudolph³, K. Budde¹
¹Department of Nephrology, Charite Campus Mitte, Berlin, Germany, ²Institut für Transfusionsmedizin, Charite Virchow Klinikum, Berlin, Germany, ³Institut für Pathologie, Charite Campus Mitte, Berlin, Germany
*Purpose: Banff classification is an accepted diagnostic tool, but also used as a tool to define endpoints in clinical trials. There is a need to…
2022 American Transplant Congress
Non-HLA Autoantibodies: The Hidden Offenders to Double the Trouble
R. Naik¹, W. Dabbas¹, I. Tang², J. Almario³, Z. Hajjiri¹
¹Transplant Nephrology, University of Illinois Chicago, Chicago, IL, ²University of Illinois Chicago, Chicago, IL, ³Transplant Surgery, University of Illinois Chicago, Chicago, IL
*Purpose: There is emerging evidence suggesting non-HLA autoantibodies triggered after the graft injury. Here, we report 3 cases where non-HLA autoantibodies were positive after 3…
2022 American Transplant Congress
Urinary Exosomal MicroRNA Biomarkers for Antibody-Mediated Rejection After Kidney Transplantation
S. Shin, M. Kim, S. Lim, H. Kwon, J. Jung, Y. Ko, H. Kwon, Y. Kim
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of
*Purpose: We aimed to identify urine-derived exosomal miRNAs as diagnostic biomarkers for antibody-mediated rejection (ABMR) after kidney transplantation.*Methods: Exosomal miRNAs using differential ultracentrifugation were isolated…
2022 American Transplant Congress
The Ontario Anatomic Kidney Score (OAKS) : Quantitative Macroscopic Assessment versus Histological Grading in Pre-transplant Evaluation of Donor Kidneys
J. Mello Offerni¹, D. Matty², H. Abed³, P. Roshanov⁴, A. Sener¹, P. Luke¹
¹Urology, Western University, London, ON, Canada, ²Undergraduate Medical Education, Western University, Schulich School of Medicine & Dentistry, London, ON, Canada, ³Division of Urology, Department of Surgery, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada, ⁴Division of Nephrology, Department of Internal Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada
*Purpose: Quantitative gross assessment of a kidney has not been used to influence the evaluation to utilize a kidney for transplantation. The Ontario Anatomic Kidney…
2022 American Transplant Congress
New Oral Anticoagulants vs Warfarin in Kidney Transplant
S. R. Raslan¹, D. Alkortas²
¹Pharmaceutical Care, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, ²KFSH & RC, Riyadh, Saudi Arabia
*Purpose: New oral anticoagulants (NOACs) have replaced warfarin due to their similar efficacy and better safety profile in the general population (GP). The risk of…
2022 American Transplant Congress
Clear Gender Disparity in Living Donor Kidney Transplants
A. C. Gruessner¹, R. Gruessner²
¹Medicine, SUNY Downstate Medical Center, Brooklyn, NY, ²SUNY Downstate Medical University, Brooklyn, NY
*Purpose: Over the last years, the number of kidney transplants from living donors (LD) increased. However, more male than female patients received a LD transplant…
2022 American Transplant Congress
The Association Between Renal Anatomy Data and Kidney Utilization
A. M. Placona, C. Martinez, K. McCharen, B. Shean, M. Stuart
United Network for Organ Sharing, Richmond, VA
*Purpose: Renal anatomy data, such as hard arterial plaque or discoloration, can be available as PDF attachments uploaded to DonorNet during the organ evaluation process.…
2022 American Transplant Congress
Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial to Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing iκB-α
Z. Gui¹, W. Zijie², M. Zheng³, M. Gu¹, R. Tan³
¹Department of Urology, The Second Affiliated Hospital with Nanjing Medical University, Nanjing, China, ²Jiangsu Province Hospital, Nanjing, China, ³Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China
*Purpose: Chronic allograft dysfunction (CAD) is the major cause of late graft loss in long-term renal transplantation. In our previous study, we found Epithelial-mesenchymal transition…
2022 American Transplant Congress
Wide Spectrum of Molecular Injury Highlights Heterogeneity of Banff Tubulitis and Interstitial Inflammation Lesions
M. J. Ellis¹, T. Maw², E. Huang³, E. Stites⁴, F. Shihab⁵, D. C. Brennan⁶, G. Shekhtman⁷, N. Agrawal⁷, J. Zeng⁷, S. Kung⁸
¹Duke University, Durham, NC, ²University of Southern California, Los Angeles, CA, ³Cedars-Sinai Medical Center, Los Angeles, CA, ⁴University of Colorado, Aurora, CO, ⁵University of Utah, Salt Lake City, UT, ⁶Johns Hopkins School of Medicine, Baltimore, MD, ⁷CareDx, Brisbane, CA, ⁸University of California, San Francisco, San Francisco, CA
*Purpose: The pathological definition and clinical significance of borderline T cell-mediated rejection (BL-TCMR) remains an area of active debate, leading to inconsistencies in therapeutic strategy.…