Articles tagged "Kidney transplantation"

2015 American Transplant Congress
HLA Broad Antigen and Eplet Mismatches in Determining the Risk of Acute Rejection After Kidney Transplantation
H. Do Nguyen,¹ W. Lim,^1,2 J. Chapman,³ J. Craig,^3,4 G. Wong.^3,4
¹School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia; ²Renal Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia; ³Nephrology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia; ⁴School of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Aim: To determine the clinical relevance of HLA-ABDR broad antigen and eplet matching for predicting acute rejection after kidney transplantation.Background: HLAMatchmaker determines structurally HLA compatibility…
2015 American Transplant Congress
Donor-Specific Alloantibody After Positive Crossmatch Kidney Transplantation With Eculizumab (EC): Correlation With Transplant Glomerulopathy and Graft Failure
C. Schinstock,¹ F. Cosio,¹ L. Cornell,¹ M. Gandhi,¹ M. Everly,² M. Stegall.¹
¹Mayo Clinic, Rochester, MN; ²Paul Terasaki Foundation, Los Angeles, CA.
Introduction. EC (C5 blockade) reduces the incidence of early clinical acute antibody mediated rejection (AMR) after +XMKTx, but does not prevent chronic AMR. We examined…
2015 American Transplant Congress
Multicenter Validation of a Molecular Diagnostic for Antibody-Mediated Rejection in Formalin-Fixed Paraffin-Embedded Human Renal Allograft Biopsies
B. Adam,¹ B. Afzali,¹ N. Shah,¹ K. Dominy,² R. Gill,¹ L. Hidalgo,¹ P. Campbell,¹ C. Roufosse,² M. Mengel,¹ B. Sis.¹
¹University of Alberta, Edmonton, Canada; ²Imperial College, London, United Kingdom.
Background: In 2013, the Banff classification adopted molecular diagnostics as an adjunct for the diagnosis of antibody-mediated rejection (ABMR) in renal allografts. The NanoString gene…
2015 American Transplant Congress
CHBP Suppresses Acute Rejection by Inhibition Maturation of Dendritic Cells though Jak-2/STAT3/SOCS1 Signal in Rat Kidney Transplantation
C. Yang,¹ Y. Zhang,¹ J. Wang,¹ L. Li,¹ L. Wang,² M. Xu,¹ Y. Long,³ R. Rong,¹ T. Zhu.¹
¹Urology, Zhongshan Hospital, Fudan University, Shanghai, China; ²Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China; ³CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Background. Renal acute rejection (AR) affects both allografts and recipients survival. We recently synthesized a novel proteolysis-resistant cyclic helix B peptide (CHBP), which exerts promising…
2015 American Transplant Congress
Targeting Complement Pathways During Ischemia and Reperfusion: Implications for the Prevention of Delayed Graft Function
Z. Yu,¹ S. Qi,² M. Lasaro,¹ K. Bouchard,¹ C. Dow,¹ K. Moore,¹ Z. Wu,² A. Barama,² J. Xu,² K. Johnson,¹ A. Marozsan,¹ Y. Wang.¹
¹Pre-Clinical Sciences, Alexion Pharmaceutical Inc., Cheshire, CT; ²Department of Surgery, Hôpital Notre Dame and Université de Montréal, Montréal, QC, Canada.
Complement system plays a critical role in ischemia-reperfusion injury (IRI), and contributes to DGF. The aim of this study was to evaluate the effects of…
2015 American Transplant Congress
Deceased Donor Kidney Transplantation Without Calcineurin Inhibitors or Steroids
A. Kirk,^1,2 A. Guasch,¹ S. Mead,¹ A. Ghali,¹ A. Mehta,¹ H. Gebel,¹ R. Bray,¹ C. Larsen,¹ T. Pearson.¹
¹Transplant Center, Emory University, Atlanta, GA; ²Surgery, Duke University, Durham, NC.
Kidney transplantation remains limited by toxicities of calcineurin inhibitors (CNIs) and steroids. Belatacept is a less toxic CNI alternative delivered by monthly intravenous infusion, but…
2015 American Transplant Congress
The Role of Hemodialysis Social Networks in Transplantation: Five Year Follow Up of an Urban Hemodialysis Cohort
A. Pai, A. Gillespie.
Nephrology, Hypertension, and Kidney Transplantation, Temple University, Philadelphia, PA.
Background: Racial and socioeconomic disparities are well known barriers to kidney transplantation (KT), especially among minority populations. Emerging evidence suggests social networks exist within hemodialysis…
2015 American Transplant Congress
Implications of Living Donor Kidney Histology, Volume and Function on Post-Donation GFR
Z. Zaky,¹ B. Lankowsky,² S. Shah,¹ L. Herlitz,¹ A. Chiesa-Vottero,¹ K. Wallenfelsz,¹ A. Caplin,¹ D. Goldfarb,¹ S. Flechner,¹ J. Schold,¹ E. Poggio.¹
¹Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, OH; ²CWRU School of Medicine, Cleveland, OH.
Living kidney donor transplantation is the best modality for treating ESRD as it confers excellent outcomes to patients and it is safe for donors. Postdonation…
2015 American Transplant Congress
Successful Management of Post Transplant Focal Segmental Glomerulosclerosis With Plasma Exchange and Rituximab
K. Koutroutsos,¹ R. Charif,¹ C. Roufosse,² J. Galliford,¹ D. Taube,¹ M. Loucaidou.¹
¹Kidney and Transplant Centre, Imperial Healthcare NHS Trust, London, United Kingdom; ²Department of Histopathology, Imperial Healthcare NHS Trust, London, United Kingdom.
Background: Post-transplant Focal Segmental Glomerulosclerosis (FSGS) is associated with renal allograft loss. Currently, optimal treatment remains controversial. We propose a management protocol that includes treatment…
2015 American Transplant Congress
Post-Transplant Lymphoproliferative Disorders Following Alemtuzumab Induction in Kidney Transplantation
H. Sawhney, R. Charif, J. Galliford, A. Mclean, D. Taube.
Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, England, United Kingdom.
Post-Transplant Lymphoproliferative Disorder (PLTD) is a well-recognised serious complication in renal transplant recipients. Induction with lymphocyte depleting agents such as thymoglobulin has been associated with…