Articles tagged "Kidney transplantation"

2015 American Transplant Congress
No Pharmacokinetic Interaction Between Pantoprazole and Mycophenolic Acid in Renal Transplant Patents: A Randomized Crossover Study
O. Rissling, P. Glander, P. Hambach, M. Mai, S. Brakemeier, D. Klonower, F. Halleck, E. Singer, E. Schrezenmeier, M. Duerr, H. Neumayer, K. Budde.
Department of Nephrology, Charité University Hospital, Berlin, Germany.
Mycophenolic acid (MPA) is used as an immunosuppressive agent in renal transplant (tx) patients (pts). 2 formulations are on the market: The prodrug Mycophenolate-Mofetil (MMF)…
2015 American Transplant Congress
Deceased Donor HLA Antibody Incompatible Renal Transplantation Without Antibody Removal: High Incidence of Acute Rejection Reduced By T-Cell Depleting Induction Therapy
E. Jolly,¹ C. Taylor,² H. Morgan,² S. Peacock,² M. Clatworthy,¹ N. Torpey.¹
¹Division of Renal Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kingdom; ²Tissue Typing Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Aims: Screening for HLA-specific antibodies (Ab) is routine for patients on kidney transplant waiting lists, and HLA antigens to which a patient has detectable Ab…
2015 American Transplant Congress
Learning from Failures: A 7-Year Analysis of a Multi-Institutional Kidney Paired Donation Registry
D. Fumo,^1,2 V. Kapoor,¹ L. Reece,² S. Rees,² J. Kopke,² S. Stepkowski,¹ C. Smith,^1,2 M. Rees.^1,2
¹University of Toledo Medical Center, Toledo, OH; ²Alliance for Paired Donation, Maumee, OH.
Failure to convert computer-identified possible Kidney Paired Donation (KPD) exchanges into transplants has prevented KPD from reaching its full potential. The purpose of this study…
2015 American Transplant Congress
Right-Sided Kidney Transplants Are Associated With Early Graft Failure in the Setting of Delayed Graft Function
I. Hall, W. Jiang, S. Kulkarni, C. Parkih.
Yale University, New Haven, CT.
Anatomical differences between right and left kidneys may affect transplant outcomes. We sought to determine if the right kidney (RK) tends to have worse graft…
2015 American Transplant Congress
Donor Serum and Urine Proteomic Signatures Differentiate Between Immediate and Delayed Graft Function in Kidney Transplantation
M. Kaisar,^1,2 H. Huang,^1,2 Z. Akhtar,¹ H. Leuvenink,³ B. Kessler,² R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²Target Discovery Institute, University of Oxford, Oxford, United Kingdom; ³Surgical Research Laboratory, UMC, Groningen, Netherlands.
IntroductionDespite the persistent shortage of donor organs, paradoxically, many organs obtained from older higher risk donors are deemed unsuitable for transplantation and discarded. The ability…
2015 American Transplant Congress
Does PTH Play a Role in Post Kidney Transplant Leukopenia?
R. Dhawan, L. Shin, K. Lee, B. Duong, L. Aguirre, C. Parke, S. Alexopoulos, M. Smogorzewski, A. Gomez, E. Mariscal, L. Matsuoka, Y. Qazi.
Division of Transplantation, University Of Southern California. Keck Med Center, Los Angeles, CA.
Aim : Recent data suggests a role of Parathyroid hormone (PTH) on hematopoietic stem cell progenitor cells(HSPCs)[1,2]. The purpose of the study was determine the…
2015 American Transplant Congress
Renal Transplantation in Aged Over 60 Years Demonstrates Compatible Clinical Outcomes to Younger Recipients
H. Cho,¹ H. Kim,¹ C. Baeck,¹ H. Yu,¹ D.-J. Han,² M. Jo,³ S.-K. Park.¹
¹Division of Nephrology, Department of Internal Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea; ²Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea; ³Department of Preventive Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Introduction: The aim of this study was comparing clinical outcomes of kidney transplantation between aged over 60 years and younger recipientsMethods: From 1993 to 2013,…
2015 American Transplant Congress
Perfusion Disturbances and Local Infarctions After Experimental Kidney Transplantation Corralte With the Duration of Cold Ischemia Time
S. Rong,¹ R. Chen,¹ M. Meier,⁴ B. Hensen,² H. Haller,¹ K. Hueper,² F. Gueler.¹
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Radiology, Hannover Medical School, Hannover, Germany; ³Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; ⁴Imaging Center, Hannover Medical School, Hannover, Germany.
Background: Kidney transplantation in mice is challenging but offers good translational models to study mechanisms of disease. In this study allogenic and isogenic kidney transplantation…
2015 American Transplant Congress
Everolimus Plus Reduced-Exposure Calcineurin Inhibitor Versus Mycophenolate Mofetil Plus Standard-Exposure Calcineurin Inhibitor: 2-Year Results in Living Donor Kidney Transplant Recipients
Y. Watarai,¹ N. Akutsu,² K. Saito,³ Y. Nakagawa,³ O. Kamisawa,⁴ T. Kenmochi.⁵
¹Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; ²Surgery, Chiba-East Hospital, Chiba, Japan; ³Urology, Niigata University, Niigata, Japan; ⁴Medical Division, Novartis Pharma K.K., Tokyo, Japan; ⁵Transplant Surgery, Fujita Health University, Toyoake, Japan.
Purpose: To evaluate the long-term efficacy and safety of everolimus (EVR) plus reduced cyclosporine (rCsA) compared to mycophenolate mofetil (MMF) plus standard cyclosporine at 24…
2015 American Transplant Congress
Pharmacokinetics of Mycophenolic Acid (MPA) in Elderly Compared to Young Recipients in the First Year After Renal Transplantation. Data from the NEverOLd Trial
P. Romano,¹ F. Agena,² P. Ebner,¹ A. Triboni,² F. Ramos,² N. Galante,² F. Lemos,² N. Sumita,¹ E. David-Neto.²
¹Division of Central Laboratory, – Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil; ²Renal Transplantation Service, – Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil.
Elderly (≥60years) recipients are nowadays receiving renal transplants more frequently. The pharmacokinetics studies (PK) of immunosuppressive drugs in healthy volunteers, rarely, if ever, include old…