Articles tagged "Kidney transplantation"

2015 American Transplant Congress
Pre-Transplant Donor Specific Antibody With Negative Flow-Crossmatch Was Related to Higher Acute Rejection But Not to Poor Graft Survival
A. Guichard-Romero, L. Marino-Vazquez, M. Lopez, N. Castelan, A. De-Santiago, N. Uribe-Uribe, J. Alberu, L. Morales-Buenrostro.
Nephrology, Transplantation, and Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Background: DSA have been associated to lower graft survival and a higher humoral rejection rate, but there is a concern about the clinical impact of…
2015 American Transplant Congress
Alemtuzumab Induction Is Associated With Higher Risk of Polyomavirrus Associated Nephropathy (PVAN) in Kidney Transplant Recipients
H. Wadei,¹ H. Saull,² C. Enderby,² M. Mai,¹ M. Prendergast,¹ T. Gonwa.¹
¹Transplant, Mayo Clinic, Jacksonville, FL; ²Pharmacy, Mayo Clinic, Jacksonville, FL.
Incidence of PVAN on protocol kidney biopsies with alemtuzumab induction is unknown.Methods:The 1-year risk of PVAN was retrospectively compared between 200 consecutive primary kidney recipients…
2015 American Transplant Congress
Associations of Pre-Transplant Prescription Narcotic Use With Clinical Complications After Kidney Transplantation
N. Lam,¹ M. Schnitzler,² J. Tuttle-Newhall,² H. Xiao,² D. Axelrod,³ D. Brennan,⁴ V. Dharnidharka,⁴ M. Nazzal,² K. Lentine.²
¹Western University, London, ON, Canada; ²Saint Louis University, St. Louis, MO; ³Dartmouth Hitchcock Medical Center, Hanover, NH; ⁴Washington University School of Medicine, St. Louis, MO.
Background: Associations of narcotic use before kidney transplantation with post-transplant clinical outcomes are not well described.Methods: We performed a retrospective analysis of linked national registry…
2015 American Transplant Congress
Hypothermic Machine Perfusion Improves Kidney Viability through Amelioration of Vasospasm and Edema of Podocytes and Renal Tubular Epithelial Cells
Z. Zhong,¹ Z. Liu,¹ Z. Fu,² Y. Zhang,² D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Hypothermic machine perfusion (MP) may improve outcome after transplantation from donors after cardiac death (DCD) kidneys, but protective mechanisms of MP remain largely unknown. To…
2015 American Transplant Congress
Treatment of Hepatitis C Virus in Kidney Transplant Recipients With Direct Acting Anti-Viral Agents: Early Results in 12 Cases
A. Sharfuddin,¹ T. Taber,¹ M. Mujtaba,¹ M. Yaqub,¹ D. Mishler,¹ P. Kwo,² R. Vuppalanchi.²
¹Medicine/Nephrology, Indiana University, Indianapolis; ²Medicine/Hepatology, Indiana University, Indianapolis.
Background: Recently approved direct acting antiviral agents (DAA) for treatment of HCV are interferon sparing allowing an attractive treatment option for kidney transplant recipient with…
2015 American Transplant Congress
Validation of Predictive Nomograms for Delayed Graft Function in Kidney Transplant Recipients
L. Chau, O. Famure, J. Kim.
Multi-Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Background: Delayed graft function (DGF), defined by the need for dialysis within 7 days after transplantation, impacts short and long term graft outcomes. Predictive nomograms…
2015 American Transplant Congress
Prediction of Long-Term Prognosis of the Kidney Transplantation Using Comorbidity Score
J. Park,¹ E. Bae,¹ S. Kim,² D. Kim,¹ C.-S. Lim,³ K. Joo,¹ Y. Kim,¹ J. Lee.³
¹Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ²Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Korea; ³Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
Background: Comorbidity assessment is important to the informed interpretation of kidney allograft outcomes. Weights assigned to comorbidities to predict survival may vary based on the…
2015 American Transplant Congress
Microcirculation Inflammation in Early Surveillance Renal Biopsy in Sensitized Patients Did Not Correlate With Graft Outcome
P. Souza,¹ D. Machado,¹ D. David,¹ G. Bezerra,¹ F. Jota de Paula,¹ H. Rodriges,² W. Nahas,¹ E. David Neto,¹ M. Castro.¹
¹Renal Transplant Unit, HC - FMUSP, S Paulo, SP, Brazil; ²Lab de HLA, InCor, S Paulo, SP, Brazil.
Introduction: Microcirculation inflammation (MI) at 3-month renal biopsies and preformed donor-specific antibodies (DSA) are considered predictors of bad outcome in sensitized patients. Earlier biopsies and…
2015 American Transplant Congress
Longitudinal eGFR Modelling to Understand Rates of eGFR Decline in Renal Transplantation in the United Kingdom
R. Pruthi,¹ A. Casula,¹ R. Hilton,² R. Ravanan,³ P. Roderick,⁴ I. Macphee.⁵
¹UK Renal Registry, Bristol, United Kingdom; ²Guys Hospital, London, United Kingdom; ³Southmead Hospital, Bristol, United Kingdom; ⁴Southampton University, Southampton, United Kingdom; ⁵St Georges Hospital, London, United Kingdom.
Background: The rate of decline in eGFR (slope) has been independently associated with a higher risk of cardiovascular events and all cause mortality in kidney…
2015 American Transplant Congress
Long Term Outcomes With Alemtuzumab Induction Therapy for Deceased and Living Renal Transplant Recipients. A Single Center Experience
P. Vaitla, U. Patel, A. Cruz, S. Guisti, A. Moiz, C.-S. Catherine, A. Cohen, G. Loss, H. Bohorquez, I. Carmody, T. Reichman, D. Bruce, S. Anders, J. Garces.
Ochsner Clinic Foundation, New Orleans, LA.
Background:Antibody induction therapy has been used for induction in up to 80% kidney transplant recipients according to United Network for Organ Sharing. It has been…