2022 American Transplant Congress
One Nuclei at a Time: Decoding Kidney Allograft Fibrosis by Single Nuclei RNA-Sequencing
*Purpose: The biological mechanisms underpinning late graft loss due to chronic allograft dysfunction remain unknown. Single nuclei RNA-sequencing (snRNAseq) of healthy and fibrotic kidney grafts…2022 American Transplant Congress
Safety and Mortality Benefit of Direct Oral Anticoagulants in Kidney Transplant
*Purpose: Direct oral anticoagulants (DOACs) are increasingly used in renal transplant recipients (RTR). We aim to identify bleeding events and all-cause mortality between DOACs and…2022 American Transplant Congress
Burden of Leukopenia/Neutropenia Among Adult Kidney Transplant Recipients: A Systematic Literature Review of Observational Studies
*Purpose: Leukopenia/neutropenia (L/N) may affect key treatment decisions which could result in poor clinical and economic outcomes among kidney transplant recipients (KTRs). The burden of…2022 American Transplant Congress
Renal Allograft Lymphangiectasia: A Rare Post-Transplant Complication
*Purpose: Lymphangiectasia of the kidney is a rare condition characterized by benign intrarenal or extrarenal dilatation of lymphatics in the peripelvic and the perinephric regions.…2022 American Transplant Congress
Safety and Efficacy of Glucagon-Like Peptide-1 Receptor Agonists in Solid Organ Transplant
*Purpose: To evaluate the safety and efficacy of glucagon-like peptide-1 receptor agonists (GLP1-RA) in solid organ transplant (SOT).*Methods: This retrospective review included adult kidney, liver,…2022 American Transplant Congress
Variation in Definition of Death in Donation After Circulatory Death Policies
*Purpose: Organ transplantation operates through a shared network requiring organizations, hospitals, and individuals to work towards a common goal. However, the policies that govern each…2022 American Transplant Congress
Novel Peripheral Molecular Markers Predict Premature Graft Loss: Lessons Learned from Operational Tolerance Assessment
*Purpose: TOMOGRAM, European multicenter study, recently identified new cohort of kidney transplant recipients (KTR) with operational tolerance (OT) with the aim to identify new transcriptomic…2022 American Transplant Congress
Long-Term Effects of Conversion from Calcineurin Inhibitors to Sirolimus for the Recipients with Low Immunological Risk in Renal Allograft
*Purpose: To observe the long-term effects and prognosis of conversion from calcineurin inhibitors (CNIs) to sirolimus in biopsy-proven low immunological risk renal transplant recipients (RTRs).*Methods:…2022 American Transplant Congress
Plasma Donor-Derived Cell-Free DNA Longitudinal Kinetics After Kidney Transplantation in Children
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) are DNA fragments released continuously into circulation from injured donor allograft cells. In adult studies, the levels drop to a…2022 American Transplant Congress
Long-Term Kidney Allotransplant Acceptance is Defined by a Shift from a T Cell to a B Cell Rich Immune Microenvironment Within the Graft
*Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations, such as DBA/2J to C57BL/6 (B6). Tolerant renal grafts develop aggregates of…
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