Articles tagged "Kidney transplantation"

2015 American Transplant Congress
Pre-Transplant Levels of TFH cell-Inducing Pro-Inflammatory Cytokines Correlate With DSA Formation After Kidney Transplantation
C. Macedo,¹ K. Hadi,¹ B. Elinoff,¹ M. Marrari,¹ A. Zeevi,¹ B. Ramaswami,¹ G. Chalasani,¹ A. Shields,² R. Alloway,³ E. Woodle,² F. Lakkis,¹ D. Metes.¹
¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh; ²Surgery, University of Cincinnati College of Medicine, Cincinnati; ³Internal Medicine-Nephrology, University of Cincinnati College of Medicine, Cincinnati.
Donor-specific anti-HLA antibodies (DSA) represent an important biomarker for acute rejection and are a major cause of long-term graft failure after kidney transplantation (KTx). The…
2015 American Transplant Congress
No Tumor Recurrence After Renal Cell Carcinoma Resected Kidney Transplantation – 5 Year Follow Up
M. Zwierzchoniewska,¹ K. Fong,¹ D. Patel,¹ L. Mou, W. Lim,² B. He,¹ L. Delriviere.¹
¹Western Australian Kidney Transplant Surgery Service, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia; ²Western Australian Kidney Transplant Service, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
INTRODUCTION:Organ shortage remains the single most significant impediment to increasing low rate of kidney transplantation. One of the strategies to improve it, is a utilisation…
2015 American Transplant Congress
CPRA Values Are Substantially Increased for Some Candidates Subsequent to Inclusion of Unacceptable C-locus (UA-C) Antigens While Listing Practices Remain Unchanged
A. Kucheryavaya,¹ R. Bray,² A. Miller,¹ D. Tyan.³
¹UNOS, Richmond; ²Emory University Hospital, Atlanta; ³Stanford University, Palo Alto.
Background: CPRA is the % of deceased donors expected to have one or more UAs with a given candidate. Prior to 12/5/13, candidates with UA-C…
2015 American Transplant Congress
Pharmacokinetics of Tacrolimus (TAC) in Elderly Compared to Young Recipients in the First Year After Renal Transplantation. Data from the NEverOLd Trial
E. David-Neto,¹ P. Romano,² A. Triboni,¹ F. Agena,¹ P. Ebner,² F. Ramos,¹ N. Galante,¹ F. Lemos.¹
¹Renal Transplantation Service, Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil; ²Division of Central Laboratory, Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil.
Elderly (≥60years) recipients are nowadays receiving renal transplants more frequently. The pharmacokinetics studies (PK) of immunosuppressive drugs in healthy volunteers, rarely, if ever, include old…
2015 American Transplant Congress
Reduced Intensity Immunosuppression Protocol Lowers Drug Costs and May Decrease Incidences of BK Viremia and Readmissions After Kidney and Kidney/Pancreas Transplant
M. Mariski,¹ A. DeGolovine,² W. Dar,² J. Bynon,² H. Adrogué,² M. Hobeika.²
¹Dept of Pharmacy, Memorial Hermann Texas Medical Center, Houston, TX; ²Division of Immunology and Organ Transplantation, University of Texas, Houston, TX.
Purpose: To evaluate the effects of a reduced intensity immunosuppression protocol on drug costs and rates of BK viremia and readmissions.Methods: In response to high…
2015 American Transplant Congress
Vitamin D Supplementation and Acute Rejection Following Kidney Transplantation
T. Horwedel,¹ K. Botkin,¹ J. Hagopian,¹ L. Bowman,¹ D. Brennan.²
¹Barnes-Jewish Hospital, St. Louis, MO; ²Washington University in St. Louis, St. Louis, MO.
Purpose: Low serum levels of vitamin D have been associated with deleterious effects post-transplantation, including increased risk of rejection. Low serum vitamin D levels are…
2015 American Transplant Congress
Pregnancy Outcomes in Female Kidney Recipients Who Conceived Before Age 20
L. Coscia,¹ D. Armenti,¹ S. Constantinescu,² M. Moritz.¹
¹National Transplantation Pregnancy Registry, Gift of Life Institute, Philadelphia; ²Medicine, Temple University School of Medicine, Philadelphia; ³Lehigh Valley Health Network, Allentown.
The purpose of this study was to examine the pregnancy outcomes among female kidney recipients who conceived before age 20. Data were collected by the…
2015 American Transplant Congress
A Cross-Organ Tissue Gene Expression Immune Signature Predates Chronicity
Y. Ng, O. Bestard, T. Sigdel, S.-C. Hsieh, T. Tran, M. Sarwal.
Transplantation Surgery, UC San Francisco, San Francisco, CA.
Purpose Meta-analysis of 796 microarrays led to the discovery of 11 over-expressed genes (BASP1, CD6, CXCL9, CXCL10, INPP5D, ISG20, LCK, NKG7, PSMB9, RUNX3, and TAP1)…
2015 American Transplant Congress
Immune Reconstitution in Recipients of Living Donor Kidney/Hematopoietic Stem + Facilitating Cell Transplants
J. Leventhal,¹ M. Elliott,² E. Yolcu,² L. Bozulic,³ D. Tollerud,³ J. Mathew,¹ I. Konieczna,¹ M. Ison,¹ M. Badder,³ M. Abecassis,¹ J. Miller,¹ L. Gallon,¹ S. Ildstad.³
¹Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, IL; ²University of Louisville, Institute for Cellular Therapeutics, Louisville, KY; ³Regenerex, LLC, Louisville, KY.
We report the long-term results from a reduced-intensity nonmyeloablative conditioning approach to establish high levels of donor chimerism without graft-versus-host disease (GVHD) in mismatched related…
2015 American Transplant Congress
Renal Outcomes of Cross Match Positive Simultaneous Liver Kidney (SLK) Transplant Recipients Compared to Cross Match Positive Kidney Allograft Recipients
S. Vaishnav,¹ T. Taber,¹ W. Goggins,² S. Nagaraju,² J. Fridell,² A. Sharfuddin,¹ M. Yaqub,¹ D. Mishler,¹ M. Mujtaba.¹
¹IUSM, IU Health, Indianapolis, IN; ²Surgery, Transplant, Indiana University School of Medicine, Indianapolis, IN.
The protective role of liver in cross-match(XM) positive SLK recipients and its impact on the incidence of renal antibody mediated rejection (AMR) is unclear.A retrospective…